Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for APRT

Basic gene info.	Gene symbol	APRT
	Gene name	adenine phosphoribosyltransferase
	Synonyms	AMP\|APRTD
	Cytomap	UCSC genome browser: 16q24
	Genomic location	chr16 :88875876-88878342
	Type of gene	protein-coding
	RefGenes	NM_000485.2, NM_001030018.1,
	Ensembl id	ENSG00000198931
	Description	AMP diphosphorylaseAMP pyrophosphorylasetransphosphoribosidase
	Modification date	20141219
dbXrefs	MIM : 102600
	HGNC : HGNC
	Ensembl : ENSG00000198931
	HPRD : 00029
	Vega : OTTHUMG00000175454
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_APRT
	BioGPS: 353
	Gene Expression Atlas: ENSG00000198931
	The Human Protein Atlas: ENSG00000198931
Pathway	NCI Pathway Interaction Database: APRT
	KEGG: APRT
	REACTOME: APRT
	ConsensusPathDB
	Pathway Commons: APRT
Metabolism	MetaCyc: APRT
	HUMANCyc: APRT
Regulation	Ensembl's Regulation: ENSG00000198931
	miRBase: chr16 :88,875,876-88,878,342
	TargetScan: NM_000485
	cisRED: ENSG00000198931
Context	iHOP: APRT
	cancer metabolism search in PubMed: APRT
	UCL Cancer Institute: APRT
Assigned class in ccmGDB	C

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Phenotypic Information for APRT(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: APRT
	Familial Cancer Database: APRT

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_PURINE_METABOLISM REACTOME_METABOLISM_OF_NUCLEOTIDES REACTOME_PURINE_METABOLISM

Others
OMIM
Orphanet
Disease	KEGG Disease: APRT
	MedGen: APRT (Human Medical Genetics with Condition)
	ClinVar: APRT
Phenotype	MGI: APRT (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: APRT

Mutations for APRT

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows APRT related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BG475137	APRT	20	106	16	88876852	88876939	APRT	103	597	16	88875882	88876876
BQ222629	TMEM185A	1	402	X	148682100	148693035	APRT	402	812	16	88876477	88878314

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=8)	Stat. for Synonymous SNVs (# total SNVs=6)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr16:88876116-88876116	p.Q178R	2
chr16:88878307-88878307	p.M1V	2
chr16:88876845-88876845	p.L103M	1
chr16:88876887-88876887	p.R89W	1
chr16:88876134-88876134	p.P172L	1
chr16:88876893-88876893	p.R87G	1
chr16:88876189-88876189	p.V154M	1
chr16:88876924-88876924	p.A76A	1
chr16:88876190-88876190	p.C153C	1
chr16:88877971-88877971	p.I58I	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1		1	2								1					2	3		2
# mutation	1		1	2								1					2	3		2
nonsynonymous SNV												1					2	2
synonymous SNV	1		1	2														1		2

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr16:88877971	p.C153C	1
chr16:88876157	p.V150V	1
chr16:88878028	p.T132A,APRT	1
chr16:88876190	p.L130L,APRT	1
chr16:88878266	p.Q121H,APRT	1
chr16:88876199	p.L103M,APRT	1
chr16:88876484	p.R89W,APRT	1
chr16:88876490	p.R87G,APRT	1
chr16:88876515	p.A76A,APRT	1
chr16:88876845	p.I58I,APRT	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for APRT in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for APRT

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


APRT,AURKAIP1,UQCC3,C19orf60,CHMP1A,COPE,COX4I1, CTU2,FAM96B,GADD45GIP1,KLHDC4,MRPL41,MVD,PDF, RPL13,SPATA2L,SURF2,TMEM208,TRADD,TRAPPC2L,ZNF593	APRT,TEN1,CHID1,CNPY2,DDX49,EEF1D,EIF6, EXOSC4,HMG20B,ITPA,LSM7,MRPS26,NHP2,NME2, PES1,RPS15,RPUSD1,RUVBL2,SLC27A5,TIMM13,TRAPPC6A

APRT,UQCC3,C16orf13,COA4,COX4I1,CTU2,FAM195A, FAM96B,MLST8,MRPS34,NDUFB10,NTHL1,NUBP2,NUTF2, PPP4C,TEX264,THOC6,PAM16,TMEM208,TRAPPC2L,TUFM	AHCY,APRT,BID,TMEM258,DCTPP1,EXOSC5,KRTCAP3, LSM7,MLST8,MRPS12,NME2,NR2C2AP,PFDN6,PHB2, PHB,SF3B5,SNRPB,SYNGR2,TARBP2,THOC6,URM1

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for APRT

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00173	adenine phosphoribosyltransferase	approved; nutraceutical	Adenine
DB01632	adenine phosphoribosyltransferase	experimental	Alpha-Phosphoribosylpyrophosphoric Acid
DB03506	adenine phosphoribosyltransferase	experimental	9-Deazaadenine
DB04272	adenine phosphoribosyltransferase	experimental	Citric Acid
DB00640	adenine phosphoribosyltransferase	approved; investigational	Adenosine

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Cross referenced IDs for APRT

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information