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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for INHBB |
Basic gene info. | Gene symbol | INHBB |
Gene name | inhibin, beta B | |
Synonyms | - | |
Cytomap | UCSC genome browser: 2cen-q13 | |
Genomic location | chr2 :121103718-121109383 | |
Type of gene | protein-coding | |
RefGenes | NM_002193.2, | |
Ensembl id | ENSG00000163083 | |
Description | Inhibin, beta-2activin AB beta polypeptideactivin beta-B chaininhibin beta B chain | |
Modification date | 20141207 | |
dbXrefs | MIM : 147390 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163083 | ||
HPRD : 00934 | ||
Vega : OTTHUMG00000131437 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_INHBB | |
BioGPS: 3625 | ||
Gene Expression Atlas: ENSG00000163083 | ||
The Human Protein Atlas: ENSG00000163083 | ||
Pathway | NCI Pathway Interaction Database: INHBB | |
KEGG: INHBB | ||
REACTOME: INHBB | ||
ConsensusPathDB | ||
Pathway Commons: INHBB | ||
Metabolism | MetaCyc: INHBB | |
HUMANCyc: INHBB | ||
Regulation | Ensembl's Regulation: ENSG00000163083 | |
miRBase: chr2 :121,103,718-121,109,383 | ||
TargetScan: NM_002193 | ||
cisRED: ENSG00000163083 | ||
Context | iHOP: INHBB | |
cancer metabolism search in PubMed: INHBB | ||
UCL Cancer Institute: INHBB | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for INHBB(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: INHBB |
Familial Cancer Database: INHBB |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: INHBB |
MedGen: INHBB (Human Medical Genetics with Condition) | |
ClinVar: INHBB | |
Phenotype | MGI: INHBB (International Mouse Phenotyping Consortium) |
PhenomicDB: INHBB |
Mutations for INHBB |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows INHBB related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=20) | (# total SNVs=9) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr2:121106693-121106693 | p.R156Q | 3 |
chr2:121106698-121106698 | p.R158C | 3 |
chr2:121104092-121104092 | p.L110L | 3 |
chr2:121104098-121104098 | p.A112T | 2 |
chr2:121107018-121107018 | p.F264F | 2 |
chr2:121107121-121107121 | p.R299W | 2 |
chr2:121107038-121107038 | p.S271L | 2 |
chr2:121107048-121107048 | p.P274P | 1 |
chr2:121103903-121103903 | p.S47A | 1 |
chr2:121107172-121107172 | p.G316S | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 1 | 1 | 5 | 1 |   | 2 |   |   |   |   | 4 | 1 |   |   |   | 8 | 10 |   | 1 |
# mutation | 1 | 1 | 1 | 5 | 1 |   | 2 |   |   |   |   | 4 | 1 |   |   |   | 11 | 13 |   | 1 |
nonsynonymous SNV | 1 | 1 |   | 3 |   |   | 2 |   |   |   |   | 2 | 1 |   |   |   | 8 | 11 |   | 1 |
synonymous SNV |   |   | 1 | 2 | 1 |   |   |   |   |   |   | 2 |   |   |   |   | 3 | 2 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr2:121106699 | p.S271L | 2 |
chr2:121107038 | p.R158H | 2 |
chr2:121107309 | p.A234V | 1 |
chr2:121103981 | p.V355M | 1 |
chr2:121106868 | p.L238V | 1 |
chr2:121107048 | p.R361L | 1 |
chr2:121107323 | p.D73N | 1 |
chr2:121104067 | p.N247S | 1 |
chr2:121106898 | p.R361R | 1 |
chr2:121107075 | p.A101A | 1 |
Other DBs for Point Mutations |
Copy Number for INHBB in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for INHBB |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACPP,C12orf40,C4BPA,CLU,ENPP7,INHBB,KSR1, LOC284661,LOC342346,LXN,NWD1,OR56A3,OR56A4,PKN3, PLD1,SNAR-A13,SYDE1,TBX22,TCL1B,TMC1,YJEFN3 | ACBD4,ADAP1,BIN3,CHADL,CREB3,CYB5D2,EML2, EPB41L4A-AS2,GHDC,INHBB,KCTD11,LAMP1,LRP10,PELI3, RAB20,RILPL2,SLC38A10,TBC1D10A,TP53I11,TSPAN9,TSR2 |
ADIRF,CA6,CACNG6,CCK,FGF19,HGFAC,INHBB, LOC84931,MSX2P1,NOTUM,PAK7,PCDHGB2,PTK7,SLIT1, SMOC2,SOHLH1,SPDYC,TBX4,TCHH,TEX19,ZNF735 | AEBP1,ADM5,CLDN5,CYP1B1,ENPP2,FAM198A,GGT5, GRASP,FAM110D,IL1R1,INHBB,LOC441454,LRRC32,MMP14, NOTCH3,OVCH1,PDGFRB,S1PR1,SHANK3,SNAI1,SOX18 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for INHBB |
There's no related Drug. |
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Cross referenced IDs for INHBB |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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