Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for INHBB
Basic gene info.Gene symbolINHBB
Gene nameinhibin, beta B
Synonyms-
CytomapUCSC genome browser: 2cen-q13
Genomic locationchr2 :121103718-121109383
Type of geneprotein-coding
RefGenesNM_002193.2,
Ensembl idENSG00000163083
DescriptionInhibin, beta-2activin AB beta polypeptideactivin beta-B chaininhibin beta B chain
Modification date20141207
dbXrefs MIM : 147390
HGNC : HGNC
Ensembl : ENSG00000163083
HPRD : 00934
Vega : OTTHUMG00000131437
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_INHBB
BioGPS: 3625
Gene Expression Atlas: ENSG00000163083
The Human Protein Atlas: ENSG00000163083
PathwayNCI Pathway Interaction Database: INHBB
KEGG: INHBB
REACTOME: INHBB
ConsensusPathDB
Pathway Commons: INHBB
MetabolismMetaCyc: INHBB
HUMANCyc: INHBB
RegulationEnsembl's Regulation: ENSG00000163083
miRBase: chr2 :121,103,718-121,109,383
TargetScan: NM_002193
cisRED: ENSG00000163083
ContextiHOP: INHBB
cancer metabolism search in PubMed: INHBB
UCL Cancer Institute: INHBB
Assigned class in ccmGDBC

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Phenotypic Information for INHBB(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: INHBB
Familial Cancer Database: INHBB
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: INHBB
MedGen: INHBB (Human Medical Genetics with Condition)
ClinVar: INHBB
PhenotypeMGI: INHBB (International Mouse Phenotyping Consortium)
PhenomicDB: INHBB

Mutations for INHBB
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows INHBB related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=20)
Stat. for Synonymous SNVs
(# total SNVs=9)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr2:121106693-121106693p.R156Q3
chr2:121106698-121106698p.R158C3
chr2:121104092-121104092p.L110L3
chr2:121107018-121107018p.F264F2
chr2:121107121-121107121p.R299W2
chr2:121107038-121107038p.S271L2
chr2:121104098-121104098p.A112T2
chr2:121106799-121106799p.G192fs*571
chr2:121107201-121107201p.T325T1
chr2:121106995-121106995p.E257K1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample11151 2    41   810 1
# mutation11151 2    41   1113 1
nonsynonymous SNV11 3  2    21   811 1
synonymous SNV  121      2    32  
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr2:121106699p.R158H2
chr2:121107038p.S271L2
chr2:121107386p.A407S1
chr2:121104185p.R158C1
chr2:121106938p.G283G1
chr2:121107164p.D284N1
chr2:121107420p.D297N1
chr2:121104187p.E190E1
chr2:121106966p.R313P1
chr2:121107168p.R194W1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for INHBB in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for INHBB

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACPP,C12orf40,C4BPA,CLU,ENPP7,INHBB,KSR1,
LOC284661,LOC342346,LXN,NWD1,OR56A3,OR56A4,PKN3,
PLD1,SNAR-A13,SYDE1,TBX22,TCL1B,TMC1,YJEFN3
ACBD4,ADAP1,BIN3,CHADL,CREB3,CYB5D2,EML2,
EPB41L4A-AS2,GHDC,INHBB,KCTD11,LAMP1,LRP10,PELI3,
RAB20,RILPL2,SLC38A10,TBC1D10A,TP53I11,TSPAN9,TSR2

ADIRF,CA6,CACNG6,CCK,FGF19,HGFAC,INHBB,
LOC84931,MSX2P1,NOTUM,PAK7,PCDHGB2,PTK7,SLIT1,
SMOC2,SOHLH1,SPDYC,TBX4,TCHH,TEX19,ZNF735
AEBP1,ADM5,CLDN5,CYP1B1,ENPP2,FAM198A,GGT5,
GRASP,FAM110D,IL1R1,INHBB,LOC441454,LRRC32,MMP14,
NOTCH3,OVCH1,PDGFRB,S1PR1,SHANK3,SNAI1,SOX18
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for INHBB


There's no related Drug.
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Cross referenced IDs for INHBB
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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