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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ITPA |
Basic gene info. | Gene symbol | ITPA |
Gene name | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | |
Synonyms | C20orf37|HLC14-06-P|dJ794I6.3 | |
Cytomap | UCSC genome browser: 20p | |
Genomic location | chr20 :3190055-3204506 | |
Type of gene | protein-coding | |
RefGenes | NM_001267623.1, NM_033453.3,NM_181493.2,NR_052000.1,NR_052001.1, NR_052002.1, | |
Ensembl id | ENSG00000125877 | |
Description | ITPaseNTPaseinosine triphosphatase-Ainosine triphosphate pyrophosphataseinosine triphosphate pyrophosphohydrolasenon-canonical purine NTP pyrophosphatasenon-standard purine NTP pyrophosphatasenucleoside-triphosphate diphosphataseputative oncogene | |
Modification date | 20141207 | |
dbXrefs | MIM : 147520 | |
HGNC : HGNC | ||
Ensembl : ENSG00000125877 | ||
HPRD : 08856 | ||
Vega : OTTHUMG00000031738 | ||
Protein | UniProt: Q9BY32 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ITPA | |
BioGPS: 3704 | ||
Gene Expression Atlas: ENSG00000125877 | ||
The Human Protein Atlas: ENSG00000125877 | ||
Pathway | NCI Pathway Interaction Database: ITPA | |
KEGG: ITPA | ||
REACTOME: ITPA | ||
ConsensusPathDB | ||
Pathway Commons: ITPA | ||
Metabolism | MetaCyc: ITPA | |
HUMANCyc: ITPA | ||
Regulation | Ensembl's Regulation: ENSG00000125877 | |
miRBase: chr20 :3,190,055-3,204,506 | ||
TargetScan: NM_001267623 | ||
cisRED: ENSG00000125877 | ||
Context | iHOP: ITPA | |
cancer metabolism search in PubMed: ITPA | ||
UCL Cancer Institute: ITPA | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for ITPA(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ITPA |
Familial Cancer Database: ITPA |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_PURINE_METABOLISM KEGG_PYRIMIDINE_METABOLISM KEGG_DRUG_METABOLISM_OTHER_ENZYMES |
Others | |
OMIM | 147520; gene. 147520; gene. 613850; phenotype. 613850; phenotype. |
Orphanet | 284113; Susceptibility to adverse reaction due to mercaptopurine. 284113; Susceptibility to adverse reaction due to mercaptopurine. 319684; Inosine triphosphatase deficiency. 319684; Inosine triphosphatase deficiency. |
Disease | KEGG Disease: ITPA |
MedGen: ITPA (Human Medical Genetics with Condition) | |
ClinVar: ITPA | |
Phenotype | MGI: ITPA (International Mouse Phenotyping Consortium) |
PhenomicDB: ITPA |
Mutations for ITPA |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ITPA related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BM545059 | ITPA | 184 | 218 | 20 | 3204225 | 3204259 | ITPA | 218 | 656 | 20 | 3190175 | 3199279 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=16) | (# total SNVs=4) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr20:3202495-3202495 | p.I140I | 3 |
chr20:3194652-3194652 | p.E71K | 2 |
chr20:3194676-3194676 | p.A79T | 2 |
chr20:3193818-3193818 | p.V24I | 2 |
chr20:3199166-3199166 | p.L100R | 1 |
chr20:3193821-3193821 | p.Q25K | 1 |
chr20:3199229-3199229 | p.S121N | 1 |
chr20:3193840-3193840 | p.F31C | 1 |
chr20:3193842-3193842 | p.P32T | 1 |
chr20:3202497-3202497 | p.V141G | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   | 5 |   |   | 2 |   |   |   |   | 1 |   | 1 |   |   | 3 | 2 |   | 1 |
# mutation |   |   |   | 5 |   |   | 2 |   |   |   |   | 1 |   | 1 |   |   | 2 | 2 |   | 1 |
nonsynonymous SNV |   |   |   | 4 |   |   | 2 |   |   |   |   | 1 |   | 1 |   |   |   |   |   | 1 |
synonymous SNV |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   | 2 | 2 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr20:3194676 | p.A38T,ITPA | 2 |
chr20:3202495 | p.I99I,ITPA | 2 |
chr20:3204085 | p.N132N,ITPA | 1 |
chr20:3193868 | p.Y147D,ITPA | 1 |
chr20:3193981 | p.V24I,ITPA | 1 |
chr20:3194643 | p.K39N,ITPA | 1 |
chr20:3194649 | p.I40M,ITPA | 1 |
chr20:3199166 | p.G47G,ITPA | 1 |
chr20:3199170 | p.V27M,ITPA | 1 |
chr20:3204033 | p.V29F,ITPA | 1 |
Other DBs for Point Mutations |
Copy Number for ITPA in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ITPA |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
BCL7C,C19orf70,C20orf27,CCDC12,CCDC124,CDC34,CENPB, GADD45GIP1,GUK1,IDH3B,ITPA,LSM7,MRPL23,MRPS26, LINC00116,NDUFA11,NDUFA13,NDUFB7,RPS19BP1,SNRPB,ZNHIT1 | APRT,BRMS1,CHID1,COMMD5,DTYMK,EIF6,EXOSC4, ITPA,LSM7,MAZ,NHP2,PES1,PPP4C,PRPF31, PSMG3,PUS1,RALY,RUVBL2,STRA13,SURF2,TMEM208 | ||||
C20orf27,AP5S1,TMEM230,CRLS1,DDRGK1,FAM110A,FKBP1A, IDH3B,ITPA,MKKS,MRPS26,NOP56,NSFL1C,PANK2, PCNA,PSMF1,SNRPB,TRMT6,UBOX5,VPS16,ZCCHC3 | ABT1,AHCY,APTX,BID,C16orf91,CDC123,COA4, CYC1,DCTPP1,ITPA,LSM7,MRPS12,MTFP1,POP5, PSMG3,SF3B5,SNRPB,TARBP2,TIMM13,PAM16,TMX2 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for ITPA |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Organism-specific databases | PharmGKB | PA29973; -. |
Organism-specific databases | PharmGKB | PA29973; -. |
Organism-specific databases | CTD | 3704; -. |
Organism-specific databases | CTD | 3704; -. |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01033 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | approved | Mercaptopurine | ||
DB00563 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | approved | Methotrexate | ||
DB00993 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | approved | Azathioprine | ||
DB00158 | inosine triphosphatase (nucleoside triphosphate pyrophosphatase) | approved; nutraceutical | Folic Acid |
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Cross referenced IDs for ITPA |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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