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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for GSTK1 |
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Phenotypic Information for GSTK1(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: GSTK1 |
Familial Cancer Database: GSTK1 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_GLUTATHIONE_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: GSTK1 |
MedGen: GSTK1 (Human Medical Genetics with Condition) | |
ClinVar: GSTK1 | |
Phenotype | MGI: GSTK1 (International Mouse Phenotyping Consortium) |
PhenomicDB: GSTK1 |
Mutations for GSTK1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GSTK1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=16) | (# total SNVs=6) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr7:142960620-142960620 | p.P5Q | 3 |
chr7:142960615-142960615 | p.P3P | 2 |
chr7:142962174-142962174 | p.V125I | 2 |
chr7:142961186-142961186 | p.C27F | 2 |
chr7:142962353-142962353 | p.? | 2 |
chr7:142964766-142964766 | p.I159I | 2 |
chr7:142961754-142961754 | p.V90L | 1 |
chr7:142965268-142965268 | p.H208Y | 1 |
chr7:142961763-142961763 | p.E93Q | 1 |
chr7:142965912-142965912 | p.A221A | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 2 |   |   | 1 |   | 1 |   |   | 1 | 2 | 3 |   |   |   |   | 3 | 1 |   | 8 |
# mutation |   | 2 |   |   | 1 |   | 1 |   |   | 1 | 2 | 5 |   |   |   |   | 3 | 1 |   | 8 |
nonsynonymous SNV |   | 2 |   |   | 1 |   | 1 |   |   | 1 | 2 | 5 |   |   |   |   | 1 | 1 |   | 5 |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | 2 |   |   | 3 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr7:142960620 | p.P5L,GSTK1 | 3 |
chr7:142964766 | p.I215I,GSTK1 | 2 |
chr7:142962103 | p.G161W | 1 |
chr7:142965268 | p.R175C | 1 |
chr7:142962155 | p.P3H,GSTK1 | 1 |
chr7:142965912 | p.T217M,GSTK1 | 1 |
chr7:142962171 | p.H245N,GSTK1 | 1 |
chr7:142965913 | p.S16S,GSTK1 | 1 |
chr7:142960614 | p.H251N,GSTK1 | 1 |
chr7:142962174 | p.M48I,GSTK1 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for GSTK1 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ABHD14A,ALKBH4,ARF5,ATP6V1F,PPP1R35,C7orf55,CDK5, DPM3,FASTK,GSTK1,LOC440957,NAT6,NDUFA1,NDUFB2, POLR2J,RNASEK,TEX264,TMEM219,TMUB1,WBSCR22,ZNHIT1 | ATOX1,LAMTOR1,C19orf53,C6orf226,CHMP2A,CIB1,FAM58A, GSTK1,NAA38,MED11,NDUFA11,OAZ1,PTPMT1,RNF181, LAMTOR2,SERF2,TAF10,UBL5,URM1,YIF1A,ZNHIT1 | ||||
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AP1S1,ARF5,ATP5J2,ATP6V1F,ATPIF1,BLOC1S1,LAMTOR4, COX4I1,FAM195A,FIS1,GSTK1,MRPS33,NDUFA2,NDUFA4, NDUFB2,SSBP1,TMEM139,UQCRQ,WBSCR22,ZNF593,ZNHIT1 | AK2,ATPIF1,MPC2,C15orf48,CCDC12,COQ4,COX16, COX4I1,COX6A1,COX6B1,GSTK1,HSD17B8,IMP3,NDUFA2, NDUFC2,NDUFS3,SDHB,TMEM179B,TSPAN17,TXN2,UQCR10 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for GSTK1 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00143 | glutathione S-transferase kappa 1 | approved; nutraceutical | Glutathione | ![]() | ![]() |
DB04700 | glutathione S-transferase kappa 1 | experimental | GLUTATHIONE SULFINATE | ![]() | ![]() |
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Cross referenced IDs for GSTK1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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