Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for B3GNT8
Basic gene info.Gene symbolB3GNT8
Gene nameUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
SynonymsB3GALT7|BGALT15|beta3Gn-T8
CytomapUCSC genome browser: 19q13.2
Genomic locationchr19 :41931263-41934635
Type of geneprotein-coding
RefGenesNM_198540.2,
Ensembl idENSG00000177191
DescriptionBGnT-8UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7beta galactosyltransferase BGALT15beta-1,3-Gn-T8beta-1,3-N-acetylglucosaminyltransferase 8beta1,3-N-acetylglucosaminyltransferase 8
Modification date20141222
dbXrefs MIM : 615357
HGNC : HGNC
Ensembl : ENSG00000177191
HPRD : 12510
Vega : OTTHUMG00000182749
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_B3GNT8
BioGPS: 374907
Gene Expression Atlas: ENSG00000177191
The Human Protein Atlas: ENSG00000177191
PathwayNCI Pathway Interaction Database: B3GNT8
KEGG: B3GNT8
REACTOME: B3GNT8
ConsensusPathDB
Pathway Commons: B3GNT8
MetabolismMetaCyc: B3GNT8
HUMANCyc: B3GNT8
RegulationEnsembl's Regulation: ENSG00000177191
miRBase: chr19 :41,931,263-41,934,635
TargetScan: NM_198540
cisRED: ENSG00000177191
ContextiHOP: B3GNT8
cancer metabolism search in PubMed: B3GNT8
UCL Cancer Institute: B3GNT8
Assigned class in ccmGDBC

Top
Phenotypic Information for B3GNT8(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: B3GNT8
Familial Cancer Database: B3GNT8
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: B3GNT8
MedGen: B3GNT8 (Human Medical Genetics with Condition)
ClinVar: B3GNT8
PhenotypeMGI: B3GNT8 (International Mouse Phenotyping Consortium)
PhenomicDB: B3GNT8

Mutations for B3GNT8
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows B3GNT8 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=17)
Stat. for Synonymous SNVs
(# total SNVs=8)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr19:41932546-41932546p.T46T2
chr19:41932611-41932611p.W25R1
chr19:41931804-41931804p.E294K1
chr19:41932193-41932193p.R164L1
chr19:41932612-41932612p.E24E1
chr19:41931892-41931892p.P264P1
chr19:41932194-41932194p.R164*1
chr19:41932627-41932627p.L19L1
chr19:41931914-41931914p.L257R1
chr19:41932275-41932275p.S137G1

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample11121 1 4  24    3  
# mutation11121 1 4  24    3  
nonsynonymous SNV1112    2  13    2  
synonymous SNV    1 1 2  11    1  
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr19:41932063p.R168T1
chr19:41932627p.R116S1
chr19:41932155p.P112H1
chr19:41932672p.T103T1
chr19:41932174p.T46T1
chr19:41932181p.Y35Y1
chr19:41931575p.R370H1
chr19:41932338p.L31P1
chr19:41931597p.T363A1
chr19:41932349p.W25R1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for B3GNT8 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for B3GNT8

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ABTB1,B3GNT8,BAD,C17orf59,LRRC73,CCDC106,DPP7,
MZT2B,FBXL15,IRF2BP1,NPDC1,P4HTM,PALM,PHLDB3,
RNF208,SIGIRR,SPATA2L,TMEM115,VPS37D,ZNF688,ZNF775
B3GNT8,BAD,BCL7C,C1orf86,C6orf1,C9orf16,COPE,
CRIP2,FBXL15,JOSD2,NME3,PLSCR3,PTMS,RABAC1,
RBM42,SELM,SIRT6,SNAPC2,SSBP4,TBCB,ZDHHC12

B3GNT8,LRRC75A,CASP6,CBLC,CDX1,CEBPA,EPN1,
FCGRT,IHH,NAPA,NR1I2,OVOL1,PHGR1,PPP1R14D,
PPP2R1A,PRRG2,PRSS8,SLC39A5,SPHK2,ST14,TMEM150B
ACAA1,ACSF2,APPL2,B3GNT8,CDKN2B,RHOV___CHP1,FAM134A,
LCMT1,MARVELD3,MGAT4B,NAAA,NEU1,P2RX4,PLEKHG6,
PRR15,SLC35D2,SPINT1,TAX1BP3,TMEM8A,TNIP1,TPRN
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for B3GNT8


There's no related Drug.
Top
Cross referenced IDs for B3GNT8
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas