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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for SLC27A1 |
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Phenotypic Information for SLC27A1(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: SLC27A1 |
Familial Cancer Database: SLC27A1 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Mutations for SLC27A1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows SLC27A1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BI009992 | ZDHHC24 | 4 | 273 | 11 | 66310112 | 66310383 | SLC27A1 | 266 | 389 | 19 | 17615616 | 17615741 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) | 1 |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=47) | (# total SNVs=17) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr19:17612144-17612144 | p.A567T | 4 |
chr19:17615314-17615314 | p.R612C | 2 |
chr19:17608117-17608117 | p.R350R | 2 |
chr19:17611525-17611525 | p.D492E | 2 |
chr19:17597398-17597398 | p.R65H | 2 |
chr19:17598003-17598003 | p.H195Y | 1 |
chr19:17611318-17611318 | p.L450I | 1 |
chr19:17599834-17599834 | p.G302W | 1 |
chr19:17611637-17611637 | p.R530C | 1 |
chr19:17597443-17597443 | p.R80H | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 2 |   | 7 | 1 |   | 3 |   | 2 | 1 |   | 5 | 2 |   |   |   | 4 | 6 |   | 14 |
# mutation | 2 | 2 |   | 6 | 1 |   | 3 |   | 2 | 1 |   | 5 | 2 |   |   |   | 4 | 6 |   | 16 |
nonsynonymous SNV |   | 1 |   | 3 | 1 |   | 1 |   | 2 | 1 |   | 3 | 1 |   |   |   | 2 | 4 |   | 10 |
synonymous SNV | 2 | 1 |   | 3 |   |   | 2 |   |   |   |   | 2 | 1 |   |   |   | 2 | 2 |   | 6 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr19:17611658 | p.A645T | 2 |
chr19:17615413 | p.V537M | 2 |
chr19:17608117 | p.H195Y | 1 |
chr19:17615329 | p.V424V | 1 |
chr19:17611209 | p.A554V | 1 |
chr19:17597672 | p.S264I | 1 |
chr19:17608160 | p.R433Q | 1 |
chr19:17615340 | p.P559P | 1 |
chr19:17611306 | p.A282A | 1 |
chr19:17597695 | p.Q443Q | 1 |
Other DBs for Point Mutations |
Copy Number for SLC27A1 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for SLC27A1 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ABTB1,ACBD4,C16orf86,C21orf2,CCDC130,CCDC159,CIRBP, CRTC1,MVB12A,GLTSCR2,LOC284440,PHF1,POLL,QTRT1, RAB11B,SIX5,SLC27A1,SSBP4,TNFSF12,UBXN6,ZDHHC1 | BTBD2,VPS51___IFT46,C12orf10,BRAT1,NELFB,CPSF3L,FUZ, MRPS2,NFKBIL1,PEX14,POLL,PRKCSH,QTRT1,RFNG, RFXANK,SIX5,SLC27A1,SPNS1,SPSB3,TMEM161A,XAB2 |
ARHGEF1,CCDC114,CHPF,DBN1,ITGA10,LMF1,LOC100127888, LOC284440,LZTS2,MC1R,PHF1,PIAS3,POLR3GL,PRX, SHB,SHC2,SHF,SLC27A1,STXBP1,TLR5,VAT1 | ADAMTS10,C2CD2,C2orf81,EPOR,GPRC5B,HDAC7,IFFO1, IQSEC1,KCND1,LEPRE1,LOXL3,LRRC2,MAN1C1,MAP3K12, MXRA8,NCKAP5L,OLFML1,PTPRS,RNF112,SIX5,SLC27A1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for SLC27A1 |
There's no related Drug. |
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Cross referenced IDs for SLC27A1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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