Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for KCNJ11
Basic gene info.Gene symbolKCNJ11
Gene namepotassium inwardly-rectifying channel, subfamily J, member 11
SynonymsBIR|HHF2|IKATP|KIR6.2|PHHI|TNDM3
CytomapUCSC genome browser: 11p15.1
Genomic locationchr11 :17406795-17410878
Type of geneprotein-coding
RefGenesNM_000525.3,
NM_001166290.1,
Ensembl idENSG00000187486
DescriptionATP-sensitive inward rectifier potassium channel 11beta-cell inward rectifier subunitinward rectifier K(+) channel Kir6.2inwardly rectifying potassium channel KIR6.2potassium channel inwardly rectifing subfamily J member 11potassium channel, inwardly
Modification date20141222
dbXrefs MIM : 600937
HGNC : HGNC
Ensembl : ENSG00000187486
HPRD : 09022
Vega : OTTHUMG00000165914
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KCNJ11
BioGPS: 3767
Gene Expression Atlas: ENSG00000187486
The Human Protein Atlas: ENSG00000187486
PathwayNCI Pathway Interaction Database: KCNJ11
KEGG: KCNJ11
REACTOME: KCNJ11
ConsensusPathDB
Pathway Commons: KCNJ11
MetabolismMetaCyc: KCNJ11
HUMANCyc: KCNJ11
RegulationEnsembl's Regulation: ENSG00000187486
miRBase: chr11 :17,406,795-17,410,878
TargetScan: NM_000525
cisRED: ENSG00000187486
ContextiHOP: KCNJ11
cancer metabolism search in PubMed: KCNJ11
UCL Cancer Institute: KCNJ11
Assigned class in ccmGDBC

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Phenotypic Information for KCNJ11(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: KCNJ11
Familial Cancer Database: KCNJ11
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: KCNJ11
MedGen: KCNJ11 (Human Medical Genetics with Condition)
ClinVar: KCNJ11
PhenotypeMGI: KCNJ11 (International Mouse Phenotyping Consortium)
PhenomicDB: KCNJ11

Mutations for KCNJ11
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows KCNJ11 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=26)
Stat. for Synonymous SNVs
(# total SNVs=9)
Stat. for Deletions
(# total SNVs=3)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr11:17408773-17408773p.G289D3
chr11:17409275-17409275p.L122F2
chr11:17409117-17409117p.A174A2
chr11:17408977-17408977p.R221L2
chr11:17409006-17409006p.I211I2
chr11:17409234-17409234p.R136fs*31
chr11:17408699-17408699p.R314S1
chr11:17408843-17408843p.P266S1
chr11:17409538-17409538p.R34H1
chr11:17409045-17409045p.F198F1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample3214  2    221 145 7
# mutation3213  2    221 245 7
nonsynonymous SNV1 12  1    121 124 5
synonymous SNV22 1  1    1   121 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr11:17408977p.R221H,KCNJ112
chr11:17409006p.I211I,KCNJ112
chr11:17409117p.A174A,KCNJ112
chr11:17409452p.C110F,KCNJ111
chr11:17408795p.V244M,KCNJ111
chr11:17409176p.A101A,KCNJ111
chr11:17409467p.M240V,KCNJ111
chr11:17408842p.C81C1
chr11:17409205p.E227K,KCNJ111
chr11:17409546p.L63L1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for KCNJ11 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for KCNJ11

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ABCC8,ARFIP2,BBS5,C14orf79,CCDC24,CCDC96,CIRBP,
DNALI1,FAAH,FRAT1,FUZ,KCNJ11,KDM4B,LRRC56,
MLPH,PIGQ,RAB17,ROGDI,SPDEF,ZNF446,ZNF467
ADSL,ALDOA,ARX,CAMK2B,CYB5R1,DYRK1B,FGGY,
GAMT,GOT2,HSPA2,IDH2,KCNJ11,MAP6D1,NEURL1,
PACSIN3,PKM,PPM1J,RTN2,SBK1,TCEA3,TPM1

ANP32A,BCL7A,FAM222A,GFRA3,IGF2-AS,KCNJ11,LIN7A,
LOC84931,MYCL,PATZ1,PVRL1,RAB15,RBM15B,SPTBN2,
TM7SF2,TP53BP1,ZNF142,ZNF282,ZNF775,ZNF777,ZSCAN10
ADCY1,ANO7,ARAP3,CACNA2D2,CDAN1,CEP192,CRACR2A,
EIF2AK4,EPHB3,GALNT8,HPS4,KCNJ11,KIAA1147,KIAA1324,
LOC400927,MAP3K15,MED23,PTK7,PVRL1,ST6GAL1,ZKSCAN1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for KCNJ11
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00222potassium inwardly-rectifying channel, subfamily J, member 11approvedGlimepiride
DB00308potassium inwardly-rectifying channel, subfamily J, member 11approvedIbutilide
DB00661potassium inwardly-rectifying channel, subfamily J, member 11approvedVerapamil
DB00922potassium inwardly-rectifying channel, subfamily J, member 11approved; investigationalLevosimendan
DB01016potassium inwardly-rectifying channel, subfamily J, member 11approvedGlyburide
DB01119potassium inwardly-rectifying channel, subfamily J, member 11approvedDiazoxide
DB01154potassium inwardly-rectifying channel, subfamily J, member 11approvedThiamylal
DB00912potassium inwardly-rectifying channel, subfamily J, member 11approved; investigationalRepaglinide
DB00121potassium inwardly-rectifying channel, subfamily J, member 11approved; nutraceuticalBiotin
DB01124potassium inwardly-rectifying channel, subfamily J, member 11approvedTolbutamide


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Cross referenced IDs for KCNJ11
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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