Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for KCNJ11

Basic gene info.	Gene symbol	KCNJ11
	Gene name	potassium inwardly-rectifying channel, subfamily J, member 11
	Synonyms	BIR\|HHF2\|IKATP\|KIR6.2\|PHHI\|TNDM3
	Cytomap	UCSC genome browser: 11p15.1
	Genomic location	chr11 :17406795-17410878
	Type of gene	protein-coding
	RefGenes	NM_000525.3, NM_001166290.1,
	Ensembl id	ENSG00000187486
	Description	ATP-sensitive inward rectifier potassium channel 11beta-cell inward rectifier subunitinward rectifier K(+) channel Kir6.2inwardly rectifying potassium channel KIR6.2potassium channel inwardly rectifing subfamily J member 11potassium channel, inwardly
	Modification date	20141222
dbXrefs	MIM : 600937
	HGNC : HGNC
	Ensembl : ENSG00000187486
	HPRD : 09022
	Vega : OTTHUMG00000165914
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_KCNJ11
	BioGPS: 3767
	Gene Expression Atlas: ENSG00000187486
	The Human Protein Atlas: ENSG00000187486
Pathway	NCI Pathway Interaction Database: KCNJ11
	KEGG: KCNJ11
	REACTOME: KCNJ11
	ConsensusPathDB
	Pathway Commons: KCNJ11
Metabolism	MetaCyc: KCNJ11
	HUMANCyc: KCNJ11
Regulation	Ensembl's Regulation: ENSG00000187486
	miRBase: chr11 :17,406,795-17,410,878
	TargetScan: NM_000525
	cisRED: ENSG00000187486
Context	iHOP: KCNJ11
	cancer metabolism search in PubMed: KCNJ11
	UCL Cancer Institute: KCNJ11
Assigned class in ccmGDB	C

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Phenotypic Information for KCNJ11(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: KCNJ11
	Familial Cancer Database: KCNJ11

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM

Others
OMIM
Orphanet
Disease	KEGG Disease: KCNJ11
	MedGen: KCNJ11 (Human Medical Genetics with Condition)
	ClinVar: KCNJ11
Phenotype	MGI: KCNJ11 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: KCNJ11

Mutations for KCNJ11

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows KCNJ11 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=26)	Stat. for Synonymous SNVs (# total SNVs=9)

Stat. for Deletions (# total SNVs=3)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr11:17408773-17408773	p.G289D	3
chr11:17409117-17409117	p.A174A	2
chr11:17408977-17408977	p.R221L	2
chr11:17409006-17409006	p.I211I	2
chr11:17409275-17409275	p.L122F	2
chr11:17408923-17408923	p.P239H	1
chr11:17409584-17409584	p.E19Q	1
chr11:17408534-17408534	p.R369C	1
chr11:17409069-17409069	p.A190A	1
chr11:17408781-17408781	p.I286I	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	3	2	1	4			2					2	2	1		1	4	5		7
# mutation	3	2	1	3			2					2	2	1		2	4	5		7
nonsynonymous SNV	1		1	2			1					1	2	1		1	2	4		5
synonymous SNV	2	2		1			1					1				1	2	1		2

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr11:17408977	p.R221H,KCNJ11	2
chr11:17409006	p.I211I,KCNJ11	2
chr11:17409117	p.A174A,KCNJ11	2
chr11:17409274	p.D352Y,KCNJ11	1
chr11:17408534	p.V155M,KCNJ11	1
chr11:17409628	p.R347H,KCNJ11	1
chr11:17408964	p.A145D,KCNJ11	1
chr11:17409276	p.L343L,KCNJ11	1
chr11:17408585	p.E140K,KCNJ11	1
chr11:17408965	p.V328V,KCNJ11	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for KCNJ11 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for KCNJ11

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ABCC8,ARFIP2,BBS5,C14orf79,CCDC24,CCDC96,CIRBP, DNALI1,FAAH,FRAT1,FUZ,KCNJ11,KDM4B,LRRC56, MLPH,PIGQ,RAB17,ROGDI,SPDEF,ZNF446,ZNF467	ADSL,ALDOA,ARX,CAMK2B,CYB5R1,DYRK1B,FGGY, GAMT,GOT2,HSPA2,IDH2,KCNJ11,MAP6D1,NEURL1, PACSIN3,PKM,PPM1J,RTN2,SBK1,TCEA3,TPM1

ANP32A,BCL7A,FAM222A,GFRA3,IGF2-AS,KCNJ11,LIN7A, LOC84931,MYCL,PATZ1,PVRL1,RAB15,RBM15B,SPTBN2, TM7SF2,TP53BP1,ZNF142,ZNF282,ZNF775,ZNF777,ZSCAN10	ADCY1,ANO7,ARAP3,CACNA2D2,CDAN1,CEP192,CRACR2A, EIF2AK4,EPHB3,GALNT8,HPS4,KCNJ11,KIAA1147,KIAA1324, LOC400927,MAP3K15,MED23,PTK7,PVRL1,ST6GAL1,ZKSCAN1

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for KCNJ11

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00222	potassium inwardly-rectifying channel, subfamily J, member 11	approved	Glimepiride
DB00308	potassium inwardly-rectifying channel, subfamily J, member 11	approved	Ibutilide
DB00661	potassium inwardly-rectifying channel, subfamily J, member 11	approved	Verapamil
DB00922	potassium inwardly-rectifying channel, subfamily J, member 11	approved; investigational	Levosimendan
DB01016	potassium inwardly-rectifying channel, subfamily J, member 11	approved	Glyburide
DB01119	potassium inwardly-rectifying channel, subfamily J, member 11	approved	Diazoxide
DB01154	potassium inwardly-rectifying channel, subfamily J, member 11	approved	Thiamylal
DB00912	potassium inwardly-rectifying channel, subfamily J, member 11	approved; investigational	Repaglinide
DB00121	potassium inwardly-rectifying channel, subfamily J, member 11	approved; nutraceutical	Biotin
DB01124	potassium inwardly-rectifying channel, subfamily J, member 11	approved	Tolbutamide

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Cross referenced IDs for KCNJ11

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information