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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ENTPD8 |
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Phenotypic Information for ENTPD8(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ENTPD8 |
Familial Cancer Database: ENTPD8 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_PURINE_METABOLISM KEGG_PYRIMIDINE_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ENTPD8 |
MedGen: ENTPD8 (Human Medical Genetics with Condition) | |
ClinVar: ENTPD8 | |
Phenotype | MGI: ENTPD8 (International Mouse Phenotyping Consortium) |
PhenomicDB: ENTPD8 |
Mutations for ENTPD8 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ENTPD8 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=17) | (# total SNVs=4) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr9:140331357-140331357 | p.W173* | 3 |
chr9:140329762-140329762 | p.R360H | 2 |
chr9:140330978-140330978 | p.V261I | 2 |
chr9:140329763-140329763 | p.R360C | 2 |
chr9:140332516-140332516 | p.A49A | 2 |
chr9:140330501-140330501 | p.D338E | 2 |
chr9:140331135-140331135 | p.G208G | 2 |
chr9:140330543-140330543 | p.F324L | 2 |
chr9:140329754-140329754 | p.R363W | 1 |
chr9:140332474-140332475 | p.A63fs*28 | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 |   |   | 3 |   |   | 3 |   | 1 |   |   | 1 | 1 |   |   |   | 6 | 7 |   | 5 |
# mutation | 2 |   |   | 2 |   |   | 2 |   | 1 |   |   | 1 | 1 |   |   |   | 6 | 8 |   | 7 |
nonsynonymous SNV | 2 |   |   | 2 |   |   |   |   |   |   |   | 1 | 1 |   |   |   | 2 | 6 |   | 5 |
synonymous SNV |   |   |   |   |   |   | 2 |   | 1 |   |   |   |   |   |   |   | 4 | 2 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr9:140329506 | p.L275L,ENTPD8 | 2 |
chr9:140330690 | p.G413R,ENTPD8 | 2 |
chr9:140330219 | p.E7D,ENTPD8 | 1 |
chr9:140331675 | p.S235F,ENTPD8 | 1 |
chr9:140329457 | p.G429D,ENTPD8 | 1 |
chr9:140330529 | p.E168V,ENTPD8 | 1 |
chr9:140331728 | p.A419V,ENTPD8 | 1 |
chr9:140329487 | p.A167T,ENTPD8 | 1 |
chr9:140330594 | p.D418N,ENTPD8 | 1 |
chr9:140332424 | p.S153Y,ENTPD8 | 1 |
Other DBs for Point Mutations |
Copy Number for ENTPD8 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ENTPD8 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACBD4,ASCL1,CCDC24,DAK,ENTPD8,FAAH,HAGH, HSH2D,ITPKA,CCDC183,NEURL1,NOXA1,PIGQ,POLD4, RAB17,RAMP1,RET,ROGDI,SIGIRR,SULT1A1,TMPRSS6 | ABHD11,ADCK5,SYNE4,CLDN3,ENTPD8,FAM110A,KLHL35, KRT8,LRRC56,MAPK8IP2,MDK,PRSS22,PYCRL,RAB17, RAB26,RASSF7,RHPN1,SH3GLB2,SIGIRR,TMEM198,TRIB3 |
ATP2A3,BCAS1,C1orf94,CAPN11,CIDEC,ENTPD8,GALNT12, GDPD2,FAM214B,KLF4,MUC2,MYPN,NSMF,PLA2G10, SLC35C1,ST6GALNAC6,TFF1,TMEM61,TRANK1,TSPAN1,VSIG1 | AIM1L,APPL2,C12orf75,CHMP2A,CLCN2,ENTPD8,IFNGR2, IVNS1ABP,LOC100130933,LOC646627,P2RX4,PRSS8,PTTG1IP,SERINC2, SLC16A3,SLC6A10P,SLC6A8,SMPDL3A,SPINT2,TMEM127,TSPAN3 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for ENTPD8 |
There's no related Drug. |
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Cross referenced IDs for ENTPD8 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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