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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ACAT1 |
Basic gene info. | Gene symbol | ACAT1 |
Gene name | acetyl-CoA acetyltransferase 1 | |
Synonyms | ACAT|MAT|T2|THIL | |
Cytomap | UCSC genome browser: 11q22.3 | |
Genomic location | chr11 :107992257-108018891 | |
Type of gene | protein-coding | |
RefGenes | NM_000019.3, | |
Ensembl id | ENSG00000075239 | |
Description | acetoacetyl Coenzyme A thiolaseacetoacetyl-CoA thiolaseacetyl-CoA acetyltransferase, mitochondrialacetyl-Coenzyme A acetyltransferase 1mitochondrial acetoacetyl-CoA thiolase | |
Modification date | 20141207 | |
dbXrefs | MIM : 607809 | |
HGNC : HGNC | ||
Ensembl : ENSG00000075239 | ||
HPRD : 01946 | ||
Vega : OTTHUMG00000166381 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACAT1 | |
BioGPS: 38 | ||
Gene Expression Atlas: ENSG00000075239 | ||
The Human Protein Atlas: ENSG00000075239 | ||
Pathway | NCI Pathway Interaction Database: ACAT1 | |
KEGG: ACAT1 | ||
REACTOME: ACAT1 | ||
ConsensusPathDB | ||
Pathway Commons: ACAT1 | ||
Metabolism | MetaCyc: ACAT1 | |
HUMANCyc: ACAT1 | ||
Regulation | Ensembl's Regulation: ENSG00000075239 | |
miRBase: chr11 :107,992,257-108,018,891 | ||
TargetScan: NM_000019 | ||
cisRED: ENSG00000075239 | ||
Context | iHOP: ACAT1 | |
cancer metabolism search in PubMed: ACAT1 | ||
UCL Cancer Institute: ACAT1 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for ACAT1(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ACAT1 |
Familial Cancer Database: ACAT1 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_FATTY_ACID_METABOLISM KEGG_TRYPTOPHAN_METABOLISM KEGG_PYRUVATE_METABOLISM KEGG_PROPANOATE_METABOLISM KEGG_BUTANOATE_METABOLISM REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ACAT1 |
MedGen: ACAT1 (Human Medical Genetics with Condition) | |
ClinVar: ACAT1 | |
Phenotype | MGI: ACAT1 (International Mouse Phenotyping Consortium) |
PhenomicDB: ACAT1 |
Mutations for ACAT1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | ACAT1 | chr11 | 108004471 | 108004491 | ACAT1 | chr11 | 107999069 | 107999089 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ACAT1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AK024206 | ACAT1 | 1 | 748 | 11 | 108007716 | 108008511 | VPRBP | 743 | 762 | 3 | 51496761 | 51496780 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=30) | (# total SNVs=10) |
(# total SNVs=1) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr11:107992346-107992346 | p.A5P | 5 |
chr11:108009660-108009660 | p.S157S | 2 |
chr11:108017059-108017059 | p.G379A | 2 |
chr11:108009744-108009744 | p.T185T | 1 |
chr11:108013182-108013182 | p.N282S | 1 |
chr11:108004962-108004962 | p.E85* | 1 |
chr11:108017065-108017065 | p.V381A | 1 |
chr11:108009763-108009763 | p.H192N | 1 |
chr11:108013239-108013239 | p.A301V | 1 |
chr11:108005922-108005922 | p.M130V | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 2 |   | 6 |   |   |   |   |   |   | 1 |   | 2 | 2 |   | 1 |   | 3 |   | 4 |
# mutation | 1 | 2 |   | 7 |   |   |   |   |   |   | 1 |   | 2 | 3 |   | 1 |   | 3 |   | 6 |
nonsynonymous SNV |   | 2 |   | 4 |   |   |   |   |   |   |   |   | 2 | 2 |   | 1 |   | 3 |   | 5 |
synonymous SNV | 1 |   |   | 3 |   |   |   |   |   |   | 1 |   |   | 1 |   |   |   |   |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr11:108014720 | p.T185T | 1 |
chr11:108005950 | p.H192N | 1 |
chr11:108017007 | p.D212D | 1 |
chr11:108002641 | p.R27I | 1 |
chr11:108005951 | p.T239A | 1 |
chr11:108017014 | p.V29L | 1 |
chr11:108002646 | p.V240D | 1 |
chr11:108009666 | p.S35L | 1 |
chr11:108017053 | p.F261F | 1 |
chr11:108002665 | p.V45L | 1 |
Other DBs for Point Mutations |
Copy Number for ACAT1 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ACAT1 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACAT1,ALG9,ALKBH8,ARCN1,C11orf1,C11orf52,C11orf57, CUL5,DDX10,DLAT,DPAGT1,EI24,IFT46,KBTBD3, NLRX1,ECI2,PPP2R1B,SIAE,TMEM25,TRAPPC4,VPS11 | ACAT1,ACO2,ATP5B,ATPAF1,CHCHD3,ETFDH,HADHB, HOXA10,HSPB6,NRD1,OPTN,PGM1,PHYH,RRAGD, SDHB,SGCG,SLC2A4,SNTA1,ST3GAL3,SUCLA2,TBX15 | ||||
ACADSB,ACAT1,BOLA3,CHCHD4,COQ3,COQ9,DLAT, FASTKD1,FH,HSPA9,HSPD1,IMMT,LRPPRC,MRPL16, MTCH2,NDUFAF4,NDUFV1,NLN,PDHA1,SDHD,SUPV3L1 | ACAA2,ACAT1,BSG,BTBD3,CA2,CD24,CPT2, ETHE1,GHITM,LCMT1,PGM1,PKIB,PPARG,SDHA, SLC16A1,TMEM171,TSPAN7,TST,UBE2D2,UGT1A10,WDR78 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for ACAT1 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00795 | acetyl-CoA acetyltransferase 1 | approved | Sulfasalazine |
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Cross referenced IDs for ACAT1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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