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| Phenotypic Information (metabolism pathway, cancer, disease, phenome) |
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| Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG |
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| Gene Summary for PLA2G2C |
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| Phenotypic Information for PLA2G2C(metabolism pathway, cancer, disease, phenome) |
 Cancer Description | |
| Cancer | CGAP: PLA2G2C |
| Familial Cancer Database: PLA2G2C | |
| * This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in | |||||||||||||||||||
| cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
| Metabolic Pathway Description | |
| KEGG_GLYCEROPHOSPHOLIPID_METABOLISM KEGG_ARACHIDONIC_ACID_METABOLISM KEGG_LINOLEIC_ACID_METABOLISM KEGG_ALPHA_LINOLENIC_ACID_METABOLISM | |
| Mutations for PLA2G2C |
| * Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
| Structural Variants in COSMIC: go to COSMIC mutation histogram |
| There's no structural variation information in COSMIC data for this gene. |
| Related fusion transcripts : go to Chitars2.0 |
| * From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PLA2G2C related fusion information. |
| ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
| Other DBs for Structural Variants |
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| Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
| There's no copy number variation information in COSMIC data for this gene. |
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| SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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: Non-synonymous mutation, 
: Synonymous mutation, Circle size denotes number of samples. |
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| Somatic Mutation Counts per Tissue in COSMIC data |
| Stat. for Non-Synonymous SNVs (# total SNVs=13) | (# total SNVs=6) |
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(# total SNVs=1) | (# total SNVs=0) |
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| Top 10 SNVs Having the Most Samples in COSMIC data |
| * When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
| GRCh37 position | Mutation(aa) | Unique sampleID count |
| chr1:20501650-20501650 | p.S13L | 2 |
| chr1:20501656-20501656 | p.F11fs*63 | 2 |
| chr1:20490601-20490601 | p.A112A | 2 |
| chr1:20490512-20490512 | p.R142K | 2 |
| chr1:20499354-20499354 | p.L73L | 1 |
| chr1:20490579-20490579 | p.V120M | 1 |
| chr1:20499377-20499377 | p.S66P | 1 |
| chr1:20501520-20501520 | p.I56I | 1 |
| chr1:20490611-20490611 | p.R109M | 1 |
| chr1:20501525-20501525 | p.G55W | 1 |
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| SNV Counts per Each Loci in TCGA data |
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| Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
| # sample | 1 | 3 | 1 | 1 | 1 | 1 | 3 | 2 | 4 | |||||||||||
| # mutation | 1 | 3 | 1 | 1 | 1 | 1 | 3 | 2 | 4 | |||||||||||
| nonsynonymous SNV | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 3 | ||||||||||||
| synonymous SNV | 2 | 1 | 1 | 1 | 1 |
| cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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| Top 10 SNVs Having the Most Samples in TCGA data |
| * We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
| Genomic Position | Mutation(aa) | Unique sampleID count |
| chr1:20490512 | p.R142K | 2 |
| chr1:20501649 | p.V90I | 1 |
| chr1:20499297 | p.I89L | 1 |
| chr1:20501650 | p.E75K | 1 |
| chr1:20499305 | p.I56I | 1 |
| chr1:20499308 | p.G55W | 1 |
| chr1:20499350 | p.G50V | 1 |
| chr1:20501520 | p.G46G | 1 |
| chr1:20501525 | p.T34T | 1 |
| chr1:20501539 | p.T34M | 1 |
| Other DBs for Point Mutations |
| Copy Number for PLA2G2C in TCGA |
| * Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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| cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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| Gene Expression for PLA2G2C |
| Gene Expression in Cancer Cell-lines (CCLE) |
| * CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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| Differential Gene Expression in Primary Tumors (TCGA) |
| * Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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| CNV vs Gene Expression Plot |
| * This plots show the correlation between CNV and gene expression. |
: Open all plots for all cancer types
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| Gene-Gene Network Information |
| Co-Expressed gene's network Plot |
| * Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
: Open all plots for all cancer types
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| CCDC176,C9orf135,AK8,CAPN8,CCDC24,CNKSR3,D2HGDH, DLX1,DLX2,CRACR2B,GHRH,GPC3,HPN,LOC728606, MAMDC4,MYL5,PDZK1,PLA2G2C,SCNN1D,UBXN10,UBXN11 | ADAM3A,C9orf135,DNAI2,FGF20,FOXB2,LMNTD1,MAGEA11, MAGEA9B,NPSR1,OR2AE1,PABPC1P2,PLA2G2C,PLG,PPIAL4E, PRSS54,RTP1,SLC17A4,SLC30A10,SNORA18,SNORA56,STRA8 |
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| ADRB3,C14orf132,CCNA1,CDH19,CHRNA3,CSDC2,MT1M, NEFH,NEFM,NGB,NOS1,NPAS3,PHOX2B,PLA2G2C, PPP2R2B,SEL1L2,SLC18A3,SLC5A7,SOX10,ST8SIA3,STMN4 | C1orf95,C9orf9,CACNA2D1,COPZ2,DRP2,EPHA6,ESYT3, GDF5,GPR155,KLHL5,NEK10,PLA2G2C,RASSF3,SFTPD, SHISA4,SLC22A2,TCF15,TULP2,VIPR2,WDR17,ZEB1 |
| Co-Expressed gene's Protein-protein interaction Network Plot |
| * Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
: Open all plots for all cancer types
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| Interacting Genes (from Pathway Commons) |
: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID
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| Pharmacological Information for PLA2G2C |
| There's no related Drug. |
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| Cross referenced IDs for PLA2G2C |
| * We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
: Open all cross reference information
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