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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for PLA2G2C |
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Phenotypic Information for PLA2G2C(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: PLA2G2C |
Familial Cancer Database: PLA2G2C |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_GLYCEROPHOSPHOLIPID_METABOLISM KEGG_ARACHIDONIC_ACID_METABOLISM KEGG_LINOLEIC_ACID_METABOLISM KEGG_ALPHA_LINOLENIC_ACID_METABOLISM |
Mutations for PLA2G2C |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PLA2G2C related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=13) | (# total SNVs=6) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr1:20501650-20501650 | p.S13L | 2 |
chr1:20501656-20501656 | p.F11fs*63 | 2 |
chr1:20490601-20490601 | p.A112A | 2 |
chr1:20490512-20490512 | p.R142K | 2 |
chr1:20499308-20499308 | p.I89L | 1 |
chr1:20501587-20501587 | p.T34M | 1 |
chr1:20490538-20490538 | p.N133N | 1 |
chr1:20499350-20499350 | p.E75K | 1 |
chr1:20501649-20501649 | p.S13S | 1 |
chr1:20490553-20490553 | p.P128P | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 |   | 3 |   |   |   |   | 1 |   |   | 1 | 1 | 1 |   |   | 3 | 2 |   | 4 |
# mutation |   | 1 |   | 3 |   |   |   |   | 1 |   |   | 1 | 1 | 1 |   |   | 3 | 2 |   | 4 |
nonsynonymous SNV |   | 1 |   | 1 |   |   |   |   | 1 |   |   | 1 |   | 1 |   |   | 2 | 1 |   | 3 |
synonymous SNV |   |   |   | 2 |   |   |   |   |   |   |   |   | 1 |   |   |   | 1 | 1 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr1:20490512 | p.R142K | 2 |
chr1:20501586 | p.P128P | 1 |
chr1:20490554 | p.P128H | 1 |
chr1:20501587 | p.R109M | 1 |
chr1:20490611 | p.G92G | 1 |
chr1:20501649 | p.V90I | 1 |
chr1:20499297 | p.I89L | 1 |
chr1:20501650 | p.E75K | 1 |
chr1:20499305 | p.I56I | 1 |
chr1:20499308 | p.G55W | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for PLA2G2C |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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CCDC176,C9orf135,AK8,CAPN8,CCDC24,CNKSR3,D2HGDH, DLX1,DLX2,CRACR2B,GHRH,GPC3,HPN,LOC728606, MAMDC4,MYL5,PDZK1,PLA2G2C,SCNN1D,UBXN10,UBXN11 | ADAM3A,C9orf135,DNAI2,FGF20,FOXB2,LMNTD1,MAGEA11, MAGEA9B,NPSR1,OR2AE1,PABPC1P2,PLA2G2C,PLG,PPIAL4E, PRSS54,RTP1,SLC17A4,SLC30A10,SNORA18,SNORA56,STRA8 |
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ADRB3,C14orf132,CCNA1,CDH19,CHRNA3,CSDC2,MT1M, NEFH,NEFM,NGB,NOS1,NPAS3,PHOX2B,PLA2G2C, PPP2R2B,SEL1L2,SLC18A3,SLC5A7,SOX10,ST8SIA3,STMN4 | C1orf95,C9orf9,CACNA2D1,COPZ2,DRP2,EPHA6,ESYT3, GDF5,GPR155,KLHL5,NEK10,PLA2G2C,RASSF3,SFTPD, SHISA4,SLC22A2,TCF15,TULP2,VIPR2,WDR17,ZEB1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for PLA2G2C |
There's no related Drug. |
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Cross referenced IDs for PLA2G2C |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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