|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ARSB |
Basic gene info. | Gene symbol | ARSB |
Gene name | arylsulfatase B | |
Synonyms | ASB|G4S|MPS6 | |
Cytomap | UCSC genome browser: 5q14.1 | |
Genomic location | chr5 :78073036-78282357 | |
Type of gene | protein-coding | |
RefGenes | NM_000046.3, NM_198709.2, | |
Ensembl id | ENSG00000113273 | |
Description | N-acetylgalactosamine-4-sulfatase | |
Modification date | 20141207 | |
dbXrefs | MIM : 611542 | |
HGNC : HGNC | ||
Ensembl : ENSG00000113273 | ||
HPRD : 08358 | ||
Vega : OTTHUMG00000108129 | ||
Protein | UniProt: P15848 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ARSB | |
BioGPS: 411 | ||
Gene Expression Atlas: ENSG00000113273 | ||
The Human Protein Atlas: ENSG00000113273 | ||
Pathway | NCI Pathway Interaction Database: ARSB | |
KEGG: ARSB | ||
REACTOME: ARSB | ||
ConsensusPathDB | ||
Pathway Commons: ARSB | ||
Metabolism | MetaCyc: ARSB | |
HUMANCyc: ARSB | ||
Regulation | Ensembl's Regulation: ENSG00000113273 | |
miRBase: chr5 :78,073,036-78,282,357 | ||
TargetScan: NM_000046 | ||
cisRED: ENSG00000113273 | ||
Context | iHOP: ARSB | |
cancer metabolism search in PubMed: ARSB | ||
UCL Cancer Institute: ARSB | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
Top |
Phenotypic Information for ARSB(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: ARSB |
Familial Cancer Database: ARSB |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
REACTOME_GLYCOSPHINGOLIPID_METABOLISM REACTOME_PHOSPHOLIPID_METABOLISM REACTOME_METABOLISM_OF_PROTEINS REACTOME_SPHINGOLIPID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS REACTOME_METABOLISM_OF_CARBOHYDRATES |
![]() | |
OMIM | 253200; phenotype. 272200; phenotype. 611542; gene. |
Orphanet | 276212; Mucopolysaccharidosis type 6, rapidly progressing. 276223; Mucopolysaccharidosis type 6, slowly progressing. |
Disease | KEGG Disease: ARSB |
MedGen: ARSB (Human Medical Genetics with Condition) | |
ClinVar: ARSB | |
Phenotype | MGI: ARSB (International Mouse Phenotyping Consortium) |
PhenomicDB: ARSB |
Mutations for ARSB |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
- Statistics for Tissue and Mutation type | Top |
![]() |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
![]() |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
![]() |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | ARSB | chr5 | 78142562 | 78142582 | ARSB | chr5 | 78142622 | 78142642 |
pancreas | ARSB | chr5 | 78114153 | 78114173 | ARSB | chr5 | 78113989 | 78114009 |
pancreas | ARSB | chr5 | 78118630 | 78118830 | GRTP1 | chr13 | 114011172 | 114011372 |
pancreas | ARSB | chr5 | 78258929 | 78258949 | ARHGEF37 | chr5 | 148961386 | 148961406 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ARSB related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BP424812 | ARSB | 220 | 252 | 5 | 78231105 | 78231212 | NALCN | 251 | 277 | 13 | 102045709 | 102045736 | |
AW236827 | ARSB | 1 | 369 | 5 | 78073039 | 78073407 | DENND2A | 367 | 484 | 7 | 140293273 | 140293390 |
![]() |
Top |
![]() |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   |   | 3 |   |   |   |   |   |   |   |   |   | 1 | |||
GAIN (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   | 3 |   |   |   |   |   |   |   |   |   | 1 |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=41) | (# total SNVs=7) |
![]() | ![]() |
(# total SNVs=1) | (# total SNVs=0) |
![]() |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr5:78077685-78077685 | p.T442T | 3 |
chr5:78076339-78076339 | p.V495I | 3 |
chr5:78181442-78181442 | p.K369N | 2 |
chr5:78181507-78181507 | p.I348F | 2 |
chr5:78077750-78077750 | p.E421Q | 2 |
chr5:78260315-78260315 | p.G205V | 2 |
chr5:78135201-78135201 | p.P397P | 2 |
chr5:78181569-78181569 | p.R327Q | 2 |
chr5:78181573-78181573 | p.V326I | 2 |
chr5:78181604-78181604 | p.R315R | 1 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 4 |   | 11 |   |   | 1 |   | 2 |   |   | 4 | 1 | 1 |   |   | 4 | 4 |   | 6 |
# mutation | 3 | 4 |   | 12 |   |   | 1 |   | 2 |   |   | 4 | 1 | 1 |   |   | 4 | 4 |   | 6 |
nonsynonymous SNV | 2 | 4 |   | 9 |   |   | 1 |   | 2 |   |   | 4 | 1 |   |   |   | 1 | 4 |   | 5 |
synonymous SNV | 1 |   |   | 3 |   |   |   |   |   |   |   |   |   | 1 |   |   | 3 |   |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr5:78181573 | p.G205E,ARSB | 2 |
chr5:78260315 | p.V326I,ARSB | 2 |
chr5:78260273 | p.A431T | 1 |
chr5:78076396 | p.E243G,ARSB | 1 |
chr5:78076471 | p.P397L,ARSB | 1 |
chr5:78181629 | p.L234I,ARSB | 1 |
chr5:78076234 | p.D396D,ARSB | 1 |
chr5:78260317 | p.K230K,ARSB | 1 |
chr5:78077720 | p.E382K,ARSB | 1 |
chr5:78181641 | p.A219D,ARSB | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for ARSB |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |
ANTXR1,ARSB,C14orf37,CDH11,CHSY3,COL12A1,COL5A2, DPYSL3,DSE,FAM26E,FBN1,FSTL1,LHFPL2,LOX, LUM,MXRA5,NID2,PLXNC1,PRRX1,TIMP2,VCAN | ADAMTS6,ARSB,BCAT1,CALU,CCR1,CD200R1,CMKLR1, CYBB,DAB2,FBN1,FSTL1,LGI2,LILRB5,MPEG1, MPP1,MRC1,MS4A6A,SIGLEC1,SLC36A1,VCAN,XPNPEP2 |
![]() | |
ARHGAP31,ARSB,ATP8B2,CD93,COL4A2,ENG,FAM101B, FSTL1,FZD4,GNB4,HEG1,LAMC1,PCDH12,PLVAP, PLXDC2,RASD1,RECK,SYNE1,TCF4,TRAM2,ZEB2 | ARHGAP31,ARMCX3,ARSB,C17orf51,CCDC149,CEP170,DHX57, FAM120C,FAM161A,FAM178A,FTO,IRS1,KIRREL,MAP3K3, NCDN,PHF19,PPM1F,SETD7,SMAD9,TULP3,UBFD1 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for ARSB |
There's no related Drug. |
Top |
Cross referenced IDs for ARSB |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |