|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for MARS |
Top |
Phenotypic Information for MARS(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: MARS |
Familial Cancer Database: MARS |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
KEGG_SELENOAMINO_ACID_METABOLISM |
![]() | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: MARS |
MedGen: MARS (Human Medical Genetics with Condition) | |
ClinVar: MARS | |
Phenotype | MGI: MARS (International Mouse Phenotyping Consortium) |
PhenomicDB: MARS |
Mutations for MARS |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
- Statistics for Tissue and Mutation type | Top |
![]() |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
![]() |
- For Intra-chromosomal Variations |
There's no intra-chromosomal structural variation. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MARS related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AJ301612 | FUS | 1 | 118 | 16 | 31193868 | 31193985 | MARS | 119 | 225 | 12 | 57911163 | 57911536 | |
X92120 | EWSR1 | 1 | 262 | 22 | 29678497 | 29683123 | MARS | 263 | 883 | 12 | 57910561 | 57911536 | |
AW409902 | ARHGAP9 | 27 | 446 | 12 | 57881880 | 57883307 | MARS | 443 | 466 | 12 | 57883303 | 57883326 | |
S75763 | FUS | 1 | 271 | 16 | 31195241 | 31195717 | MARS | 270 | 377 | 12 | 57911164 | 57911538 | |
BE269882 | ARHGAP9 | 1 | 409 | 12 | 57881899 | 57883307 | MARS | 406 | 429 | 12 | 57883303 | 57883326 | |
AA345023 | FBRSL1 | 58 | 108 | 12 | 133147653 | 133147703 | MARS | 102 | 227 | 12 | 57909054 | 57909762 | |
BE295899 | ARHGAP9 | 1 | 404 | 12 | 57881899 | 57883307 | MARS | 401 | 424 | 12 | 57883303 | 57883326 | |
BC001814 | MARS | 426 | 449 | 12 | 57883303 | 57883326 | EIF3L | 450 | 2327 | 22 | 38245441 | 38284638 | |
AW410123 | MARS | 18 | 308 | 12 | 57894237 | 57905627 | MARS | 303 | 453 | 12 | 57905855 | 57906137 |
![]() |
Top |
![]() |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   | 6 |   |   |   |   |   |   | 1 |   |   |   |   | 1 | 2 |   |   | |||
GAIN (# sample) |   | 6 |   |   |   |   |   |   | 1 |   |   |   |   | 1 | 2 |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=63) | (# total SNVs=21) |
![]() | ![]() |
(# total SNVs=3) | (# total SNVs=1) |
![]() | ![]() |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr12:57883053-57883053 | p.L71fs*33 | 4 |
chr12:57892036-57892036 | p.L289L | 3 |
chr12:57883298-57883298 | p.I124T | 3 |
chr12:57906098-57906098 | p.E572V | 3 |
chr12:57906610-57906610 | p.T610T | 2 |
chr12:57910042-57910042 | p.P826P | 2 |
chr12:57908816-57908816 | p.R727W | 2 |
chr12:57905648-57905648 | p.D512E | 2 |
chr12:57894178-57894178 | p.C389Y | 2 |
chr12:57908817-57908817 | p.R727Q | 2 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 2 |   | 12 | 1 |   | 2 |   | 3 | 1 |   | 4 | 3 | 2 |   |   | 9 | 4 | 1 | 14 |
# mutation |   | 2 |   | 13 | 1 |   | 2 |   | 3 | 1 |   | 4 | 3 | 2 |   |   | 9 | 4 | 1 | 15 |
nonsynonymous SNV |   | 2 |   | 10 | 1 |   | 2 |   | 2 | 1 |   | 2 | 1 | 2 |   |   | 4 | 3 | 1 | 11 |
synonymous SNV |   |   |   | 3 |   |   |   |   | 1 |   |   | 2 | 2 |   |   |   | 5 | 1 |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr12:57910042 | p.G730D | 2 |
chr12:57906610 | p.T610T | 2 |
chr12:57908826 | p.P826P | 2 |
chr12:57905574 | p.G56D | 1 |
chr12:57882850 | p.I268L | 1 |
chr12:57884398 | p.D498Y | 1 |
chr12:57908506 | p.I728V | 1 |
chr12:57894203 | p.D78N | 1 |
chr12:57905604 | p.Y314C | 1 |
chr12:57882859 | p.P506P | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for MARS |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |||||
ASNSD1,COA7,DDX21,GTF3C3,HSPD1,LRPPRC,MARS2, MOB4,NOLC1,NOP58,PNO1,POLR1B,PRPF40A,PUS7, RQCD1,SF3B1,URB2,WDR12,WDR43,WDR75,ZC3H15 | BEND3,DSC2,FAM60A,LARS,MARS2,MCM4,MTMR1, NKRF,NOLC1,PAICS,POLR1B,PPAT,QTRTD1,SLC12A2, SMARCC1,SRPK1,SSX2IP,TEX10,URB2,USP10,ZBED4 | ||||
![]() | |||||
C2orf47,CEBPZ,DDX18,FASTKD1,FASTKD2,HSPD1,LRPPRC, MARS2,METTL8,MRPL19,MRPL30,MTIF2,NOC3L,PNO1, PNPT1,POLR1B,PTCD3,SCLY,WDR12,WDR43,WDR75 | AEN,AGPAT5,BYSL,FAM210A,FUT4,GRPEL1,KCNN4, MARS2,MECOM,PDE12,PIGW,PPIF,PUS1,RCL1, RDH13,RRP1,SEH1L,SLC25A19,TAF5L,URB2,UTP15 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for MARS |
![]() |
DB Category | DB Name | DB's ID and Url link |
![]() |
* Gene Centered Interaction Network. |
![]() |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00145 | methionyl-tRNA synthetase | approved; nutraceutical | Glycine | ![]() | ![]() |
DB00160 | methionyl-tRNA synthetase | approved; nutraceutical | L-Alanine | ![]() | ![]() |
DB00125 | methionyl-tRNA synthetase | approved; nutraceutical | L-Arginine | ![]() | ![]() |
DB00151 | methionyl-tRNA synthetase | approved; nutraceutical | L-Cysteine | ![]() | ![]() |
DB00130 | methionyl-tRNA synthetase | approved; nutraceutical; investigational | L-Glutamine | ![]() | ![]() |
DB00117 | methionyl-tRNA synthetase | approved; nutraceutical | L-Histidine | ![]() | ![]() |
DB00149 | methionyl-tRNA synthetase | approved; nutraceutical | L-Leucine | ![]() | ![]() |
DB00123 | methionyl-tRNA synthetase | approved; nutraceutical | L-Lysine | ![]() | ![]() |
DB00134 | methionyl-tRNA synthetase | approved; nutraceutical | L-Methionine | ![]() | ![]() |
DB00120 | methionyl-tRNA synthetase | approved; nutraceutical | L-Phenylalanine | ![]() | ![]() |
DB00172 | methionyl-tRNA synthetase | approved; nutraceutical | L-Proline | ![]() | ![]() |
DB00133 | methionyl-tRNA synthetase | approved; nutraceutical | L-Serine | ![]() | ![]() |
DB00156 | methionyl-tRNA synthetase | approved; nutraceutical | L-Threonine | ![]() | ![]() |
DB00150 | methionyl-tRNA synthetase | approved; nutraceutical | L-Tryptophan | ![]() | ![]() |
DB00135 | methionyl-tRNA synthetase | approved; nutraceutical | L-Tyrosine | ![]() | ![]() |
DB00161 | methionyl-tRNA synthetase | approved; nutraceutical | L-Valine | ![]() | ![]() |
Top |
Cross referenced IDs for MARS |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |