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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ME2 |
Basic gene info. | Gene symbol | ME2 |
Gene name | malic enzyme 2, NAD(+)-dependent, mitochondrial | |
Synonyms | ODS1 | |
Cytomap | UCSC genome browser: 18q21 | |
Genomic location | chr18 :48405431-48476162 | |
Type of gene | protein-coding | |
RefGenes | NM_001168335.1, NM_002396.4, | |
Ensembl id | ENSG00000082212 | |
Description | NAD-MENAD-dependent malic enzyme, mitochondrialmalate dehydrogenasepyruvic-malic carboxylase | |
Modification date | 20141207 | |
dbXrefs | MIM : 154270 | |
HGNC : HGNC | ||
HPRD : 01103 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ME2 | |
BioGPS: 4200 | ||
Gene Expression Atlas: ENSG00000082212 | ||
The Human Protein Atlas: ENSG00000082212 | ||
Pathway | NCI Pathway Interaction Database: ME2 | |
KEGG: ME2 | ||
REACTOME: ME2 | ||
ConsensusPathDB | ||
Pathway Commons: ME2 | ||
Metabolism | MetaCyc: ME2 | |
HUMANCyc: ME2 | ||
Regulation | Ensembl's Regulation: ENSG00000082212 | |
miRBase: chr18 :48,405,431-48,476,162 | ||
TargetScan: NM_001168335 | ||
cisRED: ENSG00000082212 | ||
Context | iHOP: ME2 | |
cancer metabolism search in PubMed: ME2 | ||
UCL Cancer Institute: ME2 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for ME2(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: ME2 |
Familial Cancer Database: ME2 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_PYRUVATE_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: ME2 |
MedGen: ME2 (Human Medical Genetics with Condition) | |
ClinVar: ME2 | |
Phenotype | MGI: ME2 (International Mouse Phenotyping Consortium) |
PhenomicDB: ME2 |
Mutations for ME2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
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- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | ME2 | chr18 | 48459343 | 48459363 | DPP10 | chr2 | 116168412 | 116168432 |
pancreas | ME2 | chr18 | 48423105 | 48423125 | chr18 | 48753811 | 48753831 | |
pancreas | ME2 | chr18 | 48450693 | 48450713 | chr18 | 48614967 | 48614987 | |
pancreas | ME2 | chr18 | 48457900 | 48457920 | chr18 | 48671485 | 48671505 | |
pancreas | ME2 | chr18 | 48461434 | 48461454 | chr18 | 48815333 | 48815353 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ME2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   |   |   |   |   | 4 |   | 1 |   |   |   |   |   | 1 |   |   | |||
GAIN (# sample) |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
LOSS (# sample) | 1 |   |   |   |   |   | 4 |   |   |   |   |   |   |   | 1 |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=43) | (# total SNVs=15) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr18:48446853-48446853 | p.F254F | 3 |
chr18:48458685-48458685 | p.R458* | 3 |
chr18:48473521-48473521 | p.E574E | 3 |
chr18:48439207-48439207 | p.E93D | 2 |
chr18:48439240-48439240 | p.I104M | 2 |
chr18:48444557-48444557 | p.D236D | 2 |
chr18:48434431-48434431 | p.? | 2 |
chr18:48434439-48434439 | p.A39T | 2 |
chr18:48442553-48442553 | p.S136S | 2 |
chr18:48450551-48450551 | p.A380A | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 2 |   | 10 | 1 |   | 2 |   | 2 | 1 |   | 7 | 3 |   |   |   | 4 | 4 |   | 8 |
# mutation |   | 2 |   | 9 | 1 |   | 2 |   | 2 | 1 |   | 10 | 3 |   |   |   | 4 | 4 |   | 11 |
nonsynonymous SNV |   | 2 |   | 7 | 1 |   | 1 |   | 2 | 1 |   | 9 | 2 |   |   |   | 1 | 3 |   | 9 |
synonymous SNV |   |   |   | 2 |   |   | 1 |   |   |   |   | 1 | 1 |   |   |   | 3 | 1 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr18:48434439 | p.P27S,ME2 | 2 |
chr18:48439207 | p.A39T,ME2 | 2 |
chr18:48422269 | p.E93D,ME2 | 2 |
chr18:48473491 | p.F254F,ME2 | 1 |
chr18:48442541 | p.E438Q,ME2 | 1 |
chr18:48447064 | p.R264G,ME2 | 1 |
chr18:48458652 | p.S447G,ME2 | 1 |
chr18:48422288 | p.R33I,ME2 | 1 |
chr18:48442562 | p.Y269H,ME2 | 1 |
chr18:48447080 | p.P448P,ME2 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ME2 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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MB21D1,CENPA,DSC2,ELAC1,AMER1,FAM171A1,FOXM1, GPR63,MALT1,ME2,MEX3C,NARS,PUS7,R3HDM1, RAD51AP1,SKA1,SRPK1,SUV39H2,TAF4B,TEX10,WDR43 | AP1S2,BTBD1,TCAIM,CAB39,CAMK2D,CAPZA2,EGLN1, GTPBP8,KPNA3,KPNA4,LOC653653,ME2,MEMO1,NAA50, OSBPL11,PLCL2,PPP3CB,RRAGD,SLC16A1,TM6SF1,TTL | ||||
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ATP5A1,ATP5B,ATPAF2,TIMM21,C1QBP,CHAC2,CNDP2, DLST,EIF4A1,ELAC1,FECH,IER3IP1,KIAA1468,MBD2, ME2,NARS,PCCB,PIAS2,SCO1,SKA1,TXNL1 | ABCD3,ABHD5,AKR1B10,DECR1,ECHS1,MICU2,ETFA, ETFDH,ETNK1,FAM107B,FAM45A,FDX1,GCLM,GHITM, ME2,MTCH2,NRAS,PITX2,SLMO2,TGFA,UGDH |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for ME2 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00157 | malic enzyme 2, NAD(+)-dependent, mitochondrial | approved; nutraceutical | NADH | ![]() | ![]() |
DB01677 | malic enzyme 2, NAD(+)-dependent, mitochondrial | experimental | Fumarate | ![]() | ![]() |
DB01907 | malic enzyme 2, NAD(+)-dependent, mitochondrial | experimental | Nicotinamide-Adenine-Dinucleotide | ![]() | ![]() |
DB03499 | malic enzyme 2, NAD(+)-dependent, mitochondrial | experimental | Malate Ion | ![]() | ![]() |
DB03589 | malic enzyme 2, NAD(+)-dependent, mitochondrial | experimental | Alpha-Ketomalonic Acid | ![]() | ![]() |
DB03680 | malic enzyme 2, NAD(+)-dependent, mitochondrial | experimental | Tartronate | ![]() | ![]() |
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Cross referenced IDs for ME2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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