Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ACHE
Basic gene info.Gene symbolACHE
Gene nameacetylcholinesterase (Yt blood group)
SynonymsACEE|ARACHE|N-ACHE|YT
CytomapUCSC genome browser: 7q22
Genomic locationchr7 :100487614-100493541
Type of geneprotein-coding
RefGenesNM_000665.4,
NM_001282449.1,NM_001302621.1,NM_001302622.1,NM_015831.2,
Ensembl idENSG00000087085
DescriptionYt blood groupacetylcholinesteraseapoptosis-related acetylcholinesterase
Modification date20141207
dbXrefs MIM : 100740
HGNC : HGNC
Ensembl : ENSG00000087085
HPRD : 00010
Vega : OTTHUMG00000157033
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ACHE
BioGPS: 43
Gene Expression Atlas: ENSG00000087085
The Human Protein Atlas: ENSG00000087085
PathwayNCI Pathway Interaction Database: ACHE
KEGG: ACHE
REACTOME: ACHE
ConsensusPathDB
Pathway Commons: ACHE
MetabolismMetaCyc: ACHE
HUMANCyc: ACHE
RegulationEnsembl's Regulation: ENSG00000087085
miRBase: chr7 :100,487,614-100,493,541
TargetScan: NM_000665
cisRED: ENSG00000087085
ContextiHOP: ACHE
cancer metabolism search in PubMed: ACHE
UCL Cancer Institute: ACHE
Assigned class in ccmGDBC

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Phenotypic Information for ACHE(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ACHE
Familial Cancer Database: ACHE
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM
REACTOME_PHOSPHOLIPID_METABOLISM
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: ACHE
MedGen: ACHE (Human Medical Genetics with Condition)
ClinVar: ACHE
PhenotypeMGI: ACHE (International Mouse Phenotyping Consortium)
PhenomicDB: ACHE

Mutations for ACHE
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
There's no intra-chromosomal structural variation.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
pancreasACHEchr7100489340100489360chr158342190283421922
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ACHE related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
R96128CDK614479233106192331104ACHE453827100490125100490803

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=31)
Stat. for Synonymous SNVs
(# total SNVs=16)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr7:100491611-100491611p.P81P3
chr7:100490067-100490067p.E481K3
chr7:100491461-100491461p.N131N2
chr7:100491616-100491616p.P80S2
chr7:100490875-100490875p.R327W2
chr7:100490077-100490077p.P477P2
chr7:100491150-100491150p.A235E2
chr7:100488658-100488658p.P592R2
chr7:100491298-100491298p.A186T1
chr7:100490137-100490137p.Y457Y1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample5 171 3    74 1 513 7
# mutation6 171 3    74 1 514 7
nonsynonymous SNV4  4  2    43 1 411 3
synonymous SNV2 131 1    31   13 4
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr7:100491616p.P80S,ACHE2
chr7:100491048p.N131N,ACHE2
chr7:100491461p.E481K,ACHE2
chr7:100490067p.T269M,ACHE2
chr7:100490831p.I385I,ACHE1
chr7:100491142p.A238T,ACHE1
chr7:100488880p.P81L,ACHE1
chr7:100491548p.D545Y,ACHE1
chr7:100490108p.E382A,ACHE1
chr7:100490864p.A237A,ACHE1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ACHE in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ACHE

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ACHE,ADAD2,BVES,TBC1D32,CASP8AP2,EPHB4,EPO,
FABP7,HINT3,HSF2,LYRM2,MAP3K7,MDN1,RRAGD,
SERINC1,SMPDL3A,STAG3,TRMT11,UBE2J1,UNCX,ZAN
RBFOX1,ACHE,ANKRD23,CACNG1,CALML6,CAPN3,CASQ1,
DUSP26,FITM1,FLJ41941,KCNA7,MB,MYADML2,MYBPH,
MYOM3,RYR1,TMEM38A,TNNI2,TRIM63,TRIM72,UCP3

ACHE,B3GALT4,LINC00520,C1orf94,CAPN11,CIDEC,CLDN23,
CLTB,DHRS9,MYPN,PLAC8,RIOK3,RSAD2,SAMD9,
SDCBP2,SI,TRANK1,TSPAN1,UGT1A4,UGT1A5,VSIG1
ACHE,C18orf8,CARS,CASP10,CDKN1A,CEACAM6,DIRC2,
EHD1,GPRIN1,IL3RA,IRF9,MDK,MT2A,MUC13,
MXD1,PLIN3,PPP4R1,RHOG,RIPK3,SAMD9,ZER1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ACHE
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00122acetylcholinesteraseapproved; nutraceuticalCholine
DB00382acetylcholinesteraseapprovedTacrine
DB00483acetylcholinesteraseapprovedGallamine Triethiodide
DB00545acetylcholinesteraseapprovedPyridostigmine
DB00674acetylcholinesteraseapprovedGalantamine
DB00677acetylcholinesteraseapprovedIsoflurophate
DB00733acetylcholinesteraseapprovedPralidoxime
DB00805acetylcholinesteraseapprovedMinaprine
DB00843acetylcholinesteraseapprovedDonepezil
DB00944acetylcholinesteraseapprovedDemecarium
DB00981acetylcholinesteraseapprovedPhysostigmine
DB00989acetylcholinesteraseapproved; investigationalRivastigmine
DB01010acetylcholinesteraseapprovedEdrophonium
DB01122acetylcholinesteraseapprovedAmbenonium
DB01199acetylcholinesteraseapprovedTubocurarine
DB01245acetylcholinesteraseapprovedDecamethonium
DB01364acetylcholinesteraseapprovedEphedrine
DB01400acetylcholinesteraseapprovedNeostigmine
DB01805acetylcholinesteraseexperimentalMonoisopropylphosphorylserine
DB01928acetylcholinesteraseexperimentalHuperaine A
DB02166acetylcholinesteraseexperimentalPropidium
DB02226acetylcholinesteraseexperimental3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-4-Yl]Hexyl]-Phenanthridinium
DB02343acetylcholinesteraseexperimental3,6,9,12,15-Pentaoxaheptadecane
DB02404acetylcholinesteraseexperimental1-Deoxy-1-Thio-Heptaethylene Glycol
DB02673acetylcholinesteraseexperimental(4ar,6s,8ar)-11-[8-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Octyl]-6-Hydroxy-3-Methoxy-5,6,9,10-Tetrahydro-4ah-[1]Benzofuro[3a,3,2-Ef][2]Benzazepin-11-Ium
DB02825acetylcholinesteraseexperimentalMethylphosphonic Acid Ester Group
DB02845acetylcholinesteraseexperimentalMethylphosphinic Acid
DB03005acetylcholinesteraseexperimental3,8-Diamino-6-Phenyl-5-[6-[1-[2-[(1,2,3,4-Tetrahydro-9-Acridinyl)Amino]Ethyl]-1h-1,2,3-Triazol-5-Yl]Hexyl]-Phenanthridinium
DB03128acetylcholinesteraseexperimentalAcetylcholine
DB03283acetylcholinesteraseexperimentalbeta-L-fucose
DB03359acetylcholinesteraseexperimentalM-(N,N,N-Trimethylammonio)-2,2,2-Trifluoro-1,1-Dihydroxyethylbenzene
DB03740acetylcholinesteraseexperimental2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose
DB03814acetylcholinesteraseexperimental2-(N-Morpholino)-Ethanesulfonic Acid
DB04021acetylcholinesteraseexperimentalMF268
DB04114acetylcholinesteraseexperimental3-Chloro-9-Ethyl-6,7,8,9,10,11-Hexahydro-7,11-Methanocycloocta[B]Quinolin-12-Amine
DB04556acetylcholinesteraseexperimental3-[(1s)-1-(Dimethylamino)Ethyl]Phenol
DB04614acetylcholinesteraseexperimental(R)-tacrine(10)-hupyridone
DB04615acetylcholinesteraseexperimental(S)-tacrine(10)-hupyridone
DB04616acetylcholinesteraseexperimentalTACRINE(8)-4-AMINOQUINOLINE
DB04617acetylcholinesteraseexperimental(9S)-9-[(8-AMMONIOOCTYL)AMINO]-1,2,3,4,9,10-HEXAHYDROACRIDINIUM
DB07555acetylcholinesteraseexperimental1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine
DB07701acetylcholinesteraseexperimental1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE
DB07756acetylcholinesteraseexperimental1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL
DB07822acetylcholinesteraseexperimental(1R)-1,2,2-TRIMETHYLPROPYL (S)-METHYLPHOSPHINATE
DB07846acetylcholinesteraseexperimental1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE
DB08167acetylcholinesteraseexperimental3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-IUM
DB08357acetylcholinesteraseexperimental1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE
DB08615acetylcholinesteraseexperimental2-[4-(DIMETHYLAMINO)PHENYL]-6-HYDROXY-3-METHYL-1,3-BENZOTHIAZOL-3-IUM


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Cross referenced IDs for ACHE
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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