|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ALDH6A1 |
Top |
Phenotypic Information for ALDH6A1(metabolism pathway, cancer, disease, phenome) |
![]() | |
Cancer | CGAP: ALDH6A1 |
Familial Cancer Database: ALDH6A1 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
![]() | |
KEGG_INOSITOL_PHOSPHATE_METABOLISM KEGG_PROPANOATE_METABOLISM REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Mutations for ALDH6A1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
![]() |
There's no structural variation information in COSMIC data for this gene. |
![]() |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ALDH6A1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
![]() |
Top |
![]() |
There's no copy number variation information in COSMIC data for this gene. |
Top |
![]() |
|
![]() |
Top |
![]() |
Stat. for Non-Synonymous SNVs (# total SNVs=27) | (# total SNVs=11) |
![]() | ![]() |
(# total SNVs=0) | (# total SNVs=0) |
Top |
![]() |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:74537937-74537937 | p.P231S | 2 |
chr14:74539282-74539282 | p.F48F | 2 |
chr14:74531550-74531550 | p.G493A | 2 |
chr14:74533531-74533531 | p.V367V | 2 |
chr14:74534253-74534253 | p.V291A | 2 |
chr14:74531615-74531615 | p.V471V | 2 |
chr14:74533593-74533593 | p.? | 2 |
chr14:74534275-74534275 | p.? | 2 |
chr14:74534089-74534089 | p.N346D | 2 |
chr14:74539005-74539005 | p.I83I | 2 |
Top |
![]() |
|
![]() |
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   | 1 | 7 | 1 |   |   |   | 2 |   |   | 4 | 3 | 1 |   |   | 6 | 4 |   | 3 |
# mutation |   |   | 1 | 7 | 1 |   |   |   | 2 |   |   | 4 | 3 | 1 |   |   | 4 | 4 |   | 3 |
nonsynonymous SNV |   |   |   | 6 | 1 |   |   |   |   |   |   | 2 | 2 | 1 |   |   | 3 | 4 |   | 3 |
synonymous SNV |   |   | 1 | 1 |   |   |   |   | 2 |   |   | 2 | 1 |   |   |   | 1 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
![]() |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:74537937 | p.P218T,ALDH6A1 | 3 |
chr14:74531550 | p.G480A,ALDH6A1 | 2 |
chr14:74539005 | p.N333D,ALDH6A1 | 2 |
chr14:74534089 | p.I83I,ALDH6A1 | 2 |
chr14:74534117 | p.K274K,ALDH6A1 | 1 |
chr14:74538180 | p.R522H,ALDH6A1 | 1 |
chr14:74527349 | p.T500N,ALDH6A1 | 1 |
chr14:74534179 | p.L207F,ALDH6A1 | 1 |
chr14:74538602 | p.I178T,ALDH6A1 | 1 |
chr14:74527415 | p.S477F,ALDH6A1 | 1 |
![]() |
![]() |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
![]() |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for ALDH6A1 |
![]() |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
![]() |
![]() |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
![]() |
Top |
![]() |
* This plots show the correlation between CNV and gene expression. |
![]() | |
![]() |
Top |
Gene-Gene Network Information |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
![]() | |||||
ALDH6A1,ATG2B,BTBD7,FAM161B,GLUD2,GOLGB1,GTF2A1, CIPC,MPP5,NEK9,PJA2,RREB1,SEL1L,SLC39A9, SPG11,SYNJ2BP,TRIP11,ZC3H14,ZFYVE1,ZKSCAN1,ZNF619 | ACACB,ACSS3,ACVR1C,ADH1A,ADH1B,ALDH6A1,CALCRL, RHOV___CHP1,CS,DNAH9,GHR,GYS2,HADH,LGALS12, OXCT1,PCCA,PCK1,PDP2,PECR,PFKFB1,ST3GAL6 | ||||
![]() | |||||
ALDH6A1,ATP8B1,C14orf159,COX10,CPT2,DLST,FAM160A1, GPHN,KIAA0586,KLHL28,L2HGDH,MINK1,MPP5,MUT, NIPAL1,NUMB,OSBP,PPP2R5E,SCO1,SPTLC2,SYNJ2BP | ACAD10,ALDH6A1,ALDH7A1,TMEM260,NCMAP,CDC14B,DAGLA, GCNT1,HMX3,HOXA5,HPSE2,KREMEN1,MSI1,PABPC3, PLEKHG4,POU2F3,SH2D7,SLC39A4,SLCO1C1,TAS1R3,VGLL4 |
![]() |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
![]() |
Top |
Pharmacological Information for ALDH6A1 |
![]() |
DB Category | DB Name | DB's ID and Url link |
![]() |
* Gene Centered Interaction Network. |
![]() |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00157 | aldehyde dehydrogenase 6 family, member A1 | approved; nutraceutical | NADH | ![]() | ![]() |
DB00161 | aldehyde dehydrogenase 6 family, member A1 | approved; nutraceutical | L-Valine | ![]() | ![]() |
Top |
Cross referenced IDs for ALDH6A1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |