|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ASNS |
Top |
Phenotypic Information for ASNS(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ASNS |
Familial Cancer Database: ASNS |
* This gene is included in those cancer gene databases. |
. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM KEGG_NITROGEN_METABOLISM REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ASNS |
MedGen: ASNS (Human Medical Genetics with Condition) | |
ClinVar: ASNS | |
Phenotype | MGI: ASNS (International Mouse Phenotyping Consortium) |
PhenomicDB: ASNS |
Mutations for ASNS |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | ASNS | chr7 | 97496323 | 97496343 | ASNS | chr7 | 97496656 | 97496676 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ASNS related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
Top |
Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   | 1 |   |   | 1 |   |   |   |   |   |   | 2 | 2 | 1 |   | |||
GAIN (# sample) |   |   |   | 1 |   |   | 1 |   |   |   |   |   |   | 2 | 2 | 1 |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
Top |
SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
|
Top |
Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=28) | (# total SNVs=12) |
(# total SNVs=1) | (# total SNVs=0) |
Top |
Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr7:97482666-97482666 | p.R424Q | 4 |
chr7:97486112-97486112 | p.G307V | 3 |
chr7:97488685-97488685 | p.A171A | 2 |
chr7:97482384-97482384 | p.Y488* | 2 |
chr7:97498310-97498310 | p.V53V | 2 |
chr7:97483964-97483964 | p.E389A | 2 |
chr7:97498340-97498340 | p.C43C | 2 |
chr7:97484756-97484756 | p.S349C | 2 |
chr7:97488553-97488553 | p.L215L | 1 |
chr7:97481671-97481671 | p.R529L | 1 |
Top |
SNV Counts per Each Loci in TCGA data |
|
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 2 | 1 | 6 | 1 |   | 4 |   | 2 |   |   | 9 | 4 | 1 |   |   | 9 | 6 | 1 | 6 |
# mutation |   | 2 | 1 | 5 | 1 |   | 4 |   | 2 |   |   | 9 | 5 | 1 |   |   | 10 | 6 | 1 | 8 |
nonsynonymous SNV |   | 2 | 1 | 2 | 1 |   | 4 |   | 1 |   |   | 6 | 5 | 1 |   |   | 9 | 3 |   | 7 |
synonymous SNV |   |   |   | 3 |   |   |   |   | 1 |   |   | 3 |   |   |   |   | 1 | 3 | 1 | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr7:97488685 | p.R341Q,ASNS | 2 |
chr7:97488686 | p.V32V,ASNS | 2 |
chr7:97498310 | p.A88A,ASNS | 2 |
chr7:97482666 | p.A88V,ASNS | 2 |
chr7:97481702 | p.G224V,ASNS | 1 |
chr7:97498300 | p.A73T,ASNS | 1 |
chr7:97482687 | p.A413V,ASNS | 1 |
chr7:97488238 | p.L213S,ASNS | 1 |
chr7:97481714 | p.P61L,ASNS | 1 |
chr7:97483924 | p.Q403L,ASNS | 1 |
Other DBs for Point Mutations |
Copy Number for ASNS in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for ASNS |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Top |
Protein Expression Plot (RPPA) |
*RPPA protein expression data were extracted from TCPA (The Cancer Proteome Atlas). Normalized data based on replicated based normalization (RBN) was used to draw following figures. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
Top |
CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
Top |
Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACN9,ASNS,AUNIP,C9orf40,CEBPG,CHAC1,DBF4, DNAJC2,FAM136A,GARS,IFRD1,KCMF1,MCM7,MTHFD2, NDUFAF4,PDSS1,PSAT1,PUS7,SKA1,SLC25A13,YARS | ASNS,RHNO1,VWA9,ATAT1,FAXC,SAYSD1,DDX26B, E2F5,FANCL,GSTO2,HMGN1,MCTP2,OFD1,PTPN2, RABL2A,REPS1,SDR42E1,TDP1,TRAPPC2,VANGL2,ZNF140 | ||||
ASNS,ATF4,CARS,COPS6,CPSF4,GARS,IARS, MARS,MTHFD2,PHGDH,PSAT1,PSPH,SARS,SLC3A2, SLC7A5,STC2,TARS,TUBE1,ULBP1,XPOT,YARS | ARMCX6,ASNS,ATXN10,CMSS1,CEACAM4,FAM49A,IARS, LDHB,LIG3,MARS,MLH1,MNAT1,NBN,NTRK1, PRPS1,PSAT1,S100A11,SRP68,TBC1D19,UPF3B,XPOT |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
Interacting Genes (from Pathway Commons) |
Top |
Pharmacological Information for ASNS |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00128 | asparagine synthetase (glutamine-hydrolyzing) | approved; nutraceutical | L-Aspartic Acid | ||
DB00142 | asparagine synthetase (glutamine-hydrolyzing) | approved; nutraceutical | L-Glutamic Acid | ||
DB00171 | asparagine synthetase (glutamine-hydrolyzing) | approved; nutraceutical | Adenosine triphosphate | ||
DB00174 | asparagine synthetase (glutamine-hydrolyzing) | approved; nutraceutical | L-Asparagine | ||
DB00130 | asparagine synthetase (glutamine-hydrolyzing) | approved; nutraceutical; investigational | L-Glutamine |
Top |
Cross referenced IDs for ASNS |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |