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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for MUC2 |
Basic gene info. | Gene symbol | MUC2 |
Gene name | mucin 2, oligomeric mucus/gel-forming | |
Synonyms | MLP|MUC-2|SMUC | |
Cytomap | UCSC genome browser: 11p15.5 | |
Genomic location | chr11 :1074874-1104417 | |
Type of gene | protein-coding | |
RefGenes | NM_002457.3, | |
Ensembl id | ENSG00000198788 | |
Description | intestinal mucin-2mucin 2, intestinal/trachealmucin-2mucin-like protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 158370 | |
HGNC : HGNC | ||
HPRD : 11828 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MUC2 | |
BioGPS: 4583 | ||
Gene Expression Atlas: ENSG00000198788 | ||
The Human Protein Atlas: ENSG00000198788 | ||
Pathway | NCI Pathway Interaction Database: MUC2 | |
KEGG: MUC2 | ||
REACTOME: MUC2 | ||
ConsensusPathDB | ||
Pathway Commons: MUC2 | ||
Metabolism | MetaCyc: MUC2 | |
HUMANCyc: MUC2 | ||
Regulation | Ensembl's Regulation: ENSG00000198788 | |
miRBase: chr11 :1,074,874-1,104,417 | ||
TargetScan: NM_002457 | ||
cisRED: ENSG00000198788 | ||
Context | iHOP: MUC2 | |
cancer metabolism search in PubMed: MUC2 | ||
UCL Cancer Institute: MUC2 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for MUC2(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: MUC2 |
Familial Cancer Database: MUC2 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_PROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: MUC2 |
MedGen: MUC2 (Human Medical Genetics with Condition) | |
ClinVar: MUC2 | |
Phenotype | MGI: MUC2 (International Mouse Phenotyping Consortium) |
PhenomicDB: MUC2 |
Mutations for MUC2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MUC2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BG982813 | MUC2 | 12 | 242 | 11 | 1097853 | 1098806 | LSR | 229 | 306 | 19 | 35739940 | 35740016 | |
AW842723 | TPM2 | 15 | 149 | 9 | 35689761 | 35689893 | MUC2 | 150 | 235 | 11 | 1092956 | 1093041 | |
DV080414 | MUC2 | 1 | 414 | 11 | 1075879 | 1078510 | CKM | 415 | 623 | 19 | 45818743 | 45821178 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=169) | (# total SNVs=77) |
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(# total SNVs=54) | (# total SNVs=4) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr11:1092802-1092802 | p.T1542fs*6 | 46 |
chr11:1093452-1093452 | p.P1724P | 6 |
chr11:1093354-1093354 | p.S1692T | 6 |
chr11:1093072-1093072 | p.A1598P | 6 |
chr11:1093286-1093286 | p.T1669S | 6 |
chr11:1092554-1092554 | p.I1459T | 6 |
chr11:1092910-1092910 | p.G1578S | 5 |
chr11:1093204-1093204 | p.P1642T | 5 |
chr11:1092647-1092647 | p.T1490I | 5 |
chr11:1093412-1093412 | p.T1711M | 5 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 22 | 2 | 21 | 7 |   | 7 | 2 | 15 | 4 |   | 29 | 12 |   |   | 5 | 39 | 20 | 1 | 19 |
# mutation | 3 | 21 | 2 | 24 | 7 |   | 7 | 2 | 14 | 4 |   | 29 | 12 |   |   | 4 | 51 | 25 | 1 | 25 |
nonsynonymous SNV | 2 | 16 |   | 17 | 6 |   | 5 | 1 | 11 | 3 |   | 23 | 8 |   |   |   | 31 | 15 |   | 19 |
synonymous SNV | 1 | 5 | 2 | 7 | 1 |   | 2 | 1 | 3 | 1 |   | 6 | 4 |   |   | 4 | 20 | 10 | 1 | 6 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr11:1101611 | p.T1777T | 3 |
chr11:1093448 | p.E2538K | 3 |
chr11:1093512 | p.T1756N | 3 |
chr11:1092540 | p.R1171M | 2 |
chr11:1093286 | p.S2361S | 2 |
chr11:1088727 | p.T1453T | 2 |
chr11:1097313 | p.I1540S | 2 |
chr11:1098725 | p.T1270T | 2 |
chr11:1092800 | p.D2120N | 2 |
chr11:1097728 | p.F2239L | 2 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for MUC2 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ASTL,ATP10B,BMP7,CA12,CCRN4L,DDHD2,DOC2B, IL5,LOC285401,LOC285593,MAMLD1,MUC21,MYF6,PDE5A, PEG3,PEG3-AS1,SALL1,TAS2R7,THSD7A,ZIM2,ZNF385B | CTSE,GKN2,HNF1B,KRTAP13-1,MSLN,MUC21,NAPSA, NKX2-1,PAEP,BPIFA1,PSAPL1,SCGB3A2,SFTA2,SFTA3, SFTPB,SFTPC,SLC26A9,SPINK1,TM4SF20,TM4SF5,XAGE1D | ||||
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CNBD2,GPX6,IL22,KRT75,KRTAP1-3,KRTAP1-5,KRTAP2-1, KRTAP2-2,KRTAP2-4,KRTAP4-11,KRTAP4-12,KRTAP4-4,KRTAP4-7,KRTAP4-9, KRTAP9-4,KRTAP9-8,LMO3,MT4,MUC21,PSORS1C2,TMEM30C | NA,NA,NA,NA,NA,NA,NA, NA,NA,NA,NA,NA,NA,NA, NA,NA,NA,NA,NA,NA,NA |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for MUC2 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01411 | mucin 2, oligomeric mucus/gel-forming | approved | Pranlukast | ![]() | ![]() |
DB01234 | mucin 2, oligomeric mucus/gel-forming | approved; investigational | Dexamethasone | ![]() | ![]() |
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Cross referenced IDs for MUC2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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