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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for MUC6 |
Basic gene info. | Gene symbol | MUC6 |
Gene name | mucin 6, oligomeric mucus/gel-forming | |
Synonyms | MUC-6 | |
Cytomap | UCSC genome browser: 11p15.5 | |
Genomic location | chr11 :1012823-1036706 | |
Type of gene | protein-coding | |
RefGenes | NM_005961.2, | |
Ensembl id | ENSG00000184956 | |
Description | gastric mucin-6mucin 6, gastricmucin-6 | |
Modification date | 20141222 | |
dbXrefs | MIM : 158374 | |
HGNC : HGNC | ||
Ensembl : ENSG00000184956 | ||
Vega : OTTHUMG00000165140 | ||
Protein | UniProt: Q6W4X9 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MUC6 | |
BioGPS: 4588 | ||
Gene Expression Atlas: ENSG00000184956 | ||
The Human Protein Atlas: ENSG00000184956 | ||
Pathway | NCI Pathway Interaction Database: MUC6 | |
KEGG: MUC6 | ||
REACTOME: MUC6 | ||
ConsensusPathDB | ||
Pathway Commons: MUC6 | ||
Metabolism | MetaCyc: MUC6 | |
HUMANCyc: MUC6 | ||
Regulation | Ensembl's Regulation: ENSG00000184956 | |
miRBase: chr11 :1,012,823-1,036,706 | ||
TargetScan: NM_005961 | ||
cisRED: ENSG00000184956 | ||
Context | iHOP: MUC6 | |
cancer metabolism search in PubMed: MUC6 | ||
UCL Cancer Institute: MUC6 | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for MUC6(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: MUC6 |
Familial Cancer Database: MUC6 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in STAD 6, |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 6 http://www.nature.com/ng/journal/v46/n6/full/ng.2983.html, 7Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | 158374; gene. |
Orphanet | |
Disease | KEGG Disease: MUC6 |
MedGen: MUC6 (Human Medical Genetics with Condition) | |
ClinVar: MUC6 | |
Phenotype | MGI: MUC6 (International Mouse Phenotyping Consortium) |
PhenomicDB: MUC6 |
Mutations for MUC6 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | MUC6 | chr11 | 1016139 | 1016159 | EPS8L2 | chr11 | 708188 | 708208 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MUC6 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=193) | (# total SNVs=111) |
(# total SNVs=20) | (# total SNVs=17) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr11:1017068-1017068 | p.T1911T | 22 |
chr11:1018089-1018089 | p.P1571fs*21 | 14 |
chr11:1018093-1018094 | p.P1570fs*136 | 13 |
chr11:1016907-1016907 | p.P1965H | 10 |
chr11:1017042-1017042 | p.Y1920S | 9 |
chr11:1016546-1016546 | p.S2085S | 8 |
chr11:1016548-1016548 | p.S2085T | 8 |
chr11:1018385-1018385 | p.T1472T | 7 |
chr11:1016558-1016558 | p.A2081A | 7 |
chr11:1016554-1016554 | p.A2083S | 6 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 6 | 2 | 2 | 19 | 1 |   | 9 |   | 17 | 1 | 1 | 23 | 18 | 3 |   | 2 | 23 | 31 | 1 | 16 |
# mutation | 7 | 2 | 2 | 23 | 1 |   | 9 |   | 17 | 1 | 1 | 32 | 20 | 3 |   | 2 | 25 | 37 | 1 | 21 |
nonsynonymous SNV | 5 | 2 |   | 13 | 1 |   | 7 |   | 11 |   | 1 | 21 | 16 | 2 |   | 2 | 19 | 20 | 1 | 13 |
synonymous SNV | 2 |   | 2 | 10 |   |   | 2 |   | 6 | 1 |   | 11 | 4 | 1 |   |   | 6 | 17 |   | 8 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr11:1017526 | p.P1759A | 5 |
chr11:1026380 | p.P1504P | 2 |
chr11:1017647 | p.T1997A | 2 |
chr11:1017820 | p.I916I | 2 |
chr11:1025025 | p.T1015M | 2 |
chr11:1017069 | p.A1661T | 2 |
chr11:1025193 | p.R992G | 2 |
chr11:1016812 | p.P1718P | 2 |
chr11:1018289 | p.F831F | 2 |
chr11:1025856 | p.T1911M | 2 |
Other DBs for Point Mutations |
Copy Number for MUC6 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for MUC6 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
C14orf132,CLIC5,DOK7,FGF10,FGFBP3,FHL2,GPR26, HPX,LGR6,LHX4,MGAT4A,MS4A7,MUC2,MUC6, NNAT,RCAN1,SEMA3B,SLC7A8,SNED1,UNC5A,WT1 | ABCC8,ARMC9,ASTN2,C1orf168,C9orf152,CACNA2D2,COL4A5, COL4A6,CT62,DNAH2,ETNK2,FGFR1OP,LEO1,LOC100130522, FAR2P1,LRRC48,MUC6,PAFAH2,PAX9,RAB19,SERPINA5 |
AGR2,FAM205BP,CAPZA3,CPOX,FAM69C,GP2,GPR126, HPSE,LOC100130331,MAGEA1,MAP3K6,MUC6,NRTN,OR10P1, OR10Q1,PLLP,RAB3A,STIM2,TBC1D21,TRIM7,ZNF878 | ACTRT1,AHSA2,BTBD18,C17orf47,C6orf10,CHKB-CPT1B,COL4A3, CPT1B,CRYGS,DDX26B,FER1L4,FLJ40330,HPYR1,KIAA0125, MIAT,MUC6,NEAT1,OGT,PRR5-ARHGAP8,SPRR1B,TIGD6 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for MUC6 |
There's no related Drug. |
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Cross referenced IDs for MUC6 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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