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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for MUC7 |
Basic gene info. | Gene symbol | MUC7 |
Gene name | mucin 7, secreted | |
Synonyms | MG2 | |
Cytomap | UCSC genome browser: 4q13.3 | |
Genomic location | chr4 :71337833-71348714 | |
Type of gene | protein-coding | |
RefGenes | NM_001145006.1, NM_001145007.1,NM_152291.2, | |
Ensembl id | ENSG00000171195 | |
Description | MUC-7apo-MG2mucin 7, salivarymucin-7salivary mucin-7 | |
Modification date | 20141207 | |
dbXrefs | MIM : 158375 | |
HGNC : HGNC | ||
Ensembl : ENSG00000171195 | ||
HPRD : 11759 | ||
Vega : OTTHUMG00000129916 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MUC7 | |
BioGPS: 4589 | ||
Gene Expression Atlas: ENSG00000171195 | ||
The Human Protein Atlas: ENSG00000171195 | ||
Pathway | NCI Pathway Interaction Database: MUC7 | |
KEGG: MUC7 | ||
REACTOME: MUC7 | ||
ConsensusPathDB | ||
Pathway Commons: MUC7 | ||
Metabolism | MetaCyc: MUC7 | |
HUMANCyc: MUC7 | ||
Regulation | Ensembl's Regulation: ENSG00000171195 | |
miRBase: chr4 :71,337,833-71,348,714 | ||
TargetScan: NM_001145006 | ||
cisRED: ENSG00000171195 | ||
Context | iHOP: MUC7 | |
cancer metabolism search in PubMed: MUC7 | ||
UCL Cancer Institute: MUC7 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for MUC7(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: MUC7 |
Familial Cancer Database: MUC7 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: MUC7 |
MedGen: MUC7 (Human Medical Genetics with Condition) | |
ClinVar: MUC7 | |
Phenotype | MGI: MUC7 (International Mouse Phenotyping Consortium) |
PhenomicDB: MUC7 |
Mutations for MUC7 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MUC7 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BX487918 | MALAT1 | 2 | 320 | 11 | 65266516 | 65266834 | MUC7 | 314 | 451 | 4 | 71346885 | 71347022 | |
BX487700 | MALAT1 | 2 | 379 | 11 | 65266516 | 65266893 | MUC7 | 374 | 627 | 4 | 71339738 | 71346714 | |
BX537739 | CUL9 | 1 | 497 | 6 | 43149971 | 43150467 | MUC7 | 490 | 2516 | 4 | 71346688 | 71348714 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=87) | (# total SNVs=17) |
(# total SNVs=0) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr4:71347185-71347185 | p.S242P | 9 |
chr4:71346978-71346978 | p.S173P | 9 |
chr4:71347138-71347138 | p.P226L | 4 |
chr4:71347033-71347033 | p.A191V | 4 |
chr4:71347047-71347047 | p.S196P | 4 |
chr4:71346646-71346646 | p.S62F | 3 |
chr4:71347171-71347171 | p.A237V | 3 |
chr4:71347291-71347291 | p.P277L | 3 |
chr4:71346827-71346827 | p.K122K | 3 |
chr4:71347468-71347468 | p.S336L | 3 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 4 |   | 14 | 2 |   | 4 |   | 4 |   |   | 22 | 4 | 4 |   |   | 19 | 8 | 5 | 11 |
# mutation | 4 | 4 |   | 11 | 2 |   | 4 |   | 4 |   |   | 24 | 4 | 4 |   |   | 17 | 9 | 5 | 9 |
nonsynonymous SNV | 3 | 3 |   | 9 | 1 |   | 3 |   | 3 |   |   | 22 | 3 | 2 |   |   | 16 | 5 | 4 | 8 |
synonymous SNV | 1 | 1 |   | 3 | 1 |   | 1 |   | 1 |   |   | 2 | 1 | 2 |   |   | 1 | 4 | 1 | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr4:71347185 | p.S242P,MUC7 | 6 |
chr4:71346978 | p.S173P,MUC7 | 5 |
chr4:71347138 | p.P226L,MUC7 | 4 |
chr4:71347351 | p.S62F,MUC7 | 3 |
chr4:71347468 | p.S297Y,MUC7 | 3 |
chr4:71346827 | p.K122N,MUC7 | 3 |
chr4:71347033 | p.S336L,MUC7 | 3 |
chr4:71346646 | p.A191V,MUC7 | 3 |
chr4:71346820 | p.R358Q,MUC7 | 2 |
chr4:71347020 | p.S196P,MUC7 | 2 |
Other DBs for Point Mutations |
Copy Number for MUC7 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for MUC7 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
C15orf41,C1QL3,BPIFB3,CACNA1A,CAT,CD44,CYP7A1, DMBT1,GPR85,MROH2B,KCNS1,MEIS2,MRGPRG,MUC7, OR7E156P,PLA2R1,PRM3,RBM44,RHD,TNFRSF11B,UTS2 | C1orf194,C20orf85,CACNG3,CDC20B,CDC6,EPGN,GABRA3, KRT12,KRT20,MAGEC1,MUC7,OR2T11,OR5M11,OR6C65, OR6C76,OR6N2,SOX11,TEKT1,TMIGD1,TTTY23,ZBBX |
TRAPPC3L,BSND,CABP1,CCL25,CDK6,FAM99A,FOXI1, GOLGA7B,KRT74,MUC7,LINC00028,NEUROD6,ODAM,PHACTR1, PTPRO,RAG2,SPP2,SULT1E1,SYT8,TCF7,TNNI2 | AGRP,C10orf91,C16orf92,CT45A5,FLJ46361,H2BFM,IL31, LHX1,LOC221122,LOC727924,MMP26,MUC7,LINC00112,OLIG2, OR51B2,OR6X1,PRAMEF16,PRM2,PSG7,SCARNA21,SNORA11E, TMPRSS12 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for MUC7 |
There's no related Drug. |
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Cross referenced IDs for MUC7 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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