Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MUC7
Basic gene info.Gene symbolMUC7
Gene namemucin 7, secreted
SynonymsMG2
CytomapUCSC genome browser: 4q13.3
Genomic locationchr4 :71337833-71348714
Type of geneprotein-coding
RefGenesNM_001145006.1,
NM_001145007.1,NM_152291.2,
Ensembl idENSG00000171195
DescriptionMUC-7apo-MG2mucin 7, salivarymucin-7salivary mucin-7
Modification date20141207
dbXrefs MIM : 158375
HGNC : HGNC
Ensembl : ENSG00000171195
HPRD : 11759
Vega : OTTHUMG00000129916
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MUC7
BioGPS: 4589
Gene Expression Atlas: ENSG00000171195
The Human Protein Atlas: ENSG00000171195
PathwayNCI Pathway Interaction Database: MUC7
KEGG: MUC7
REACTOME: MUC7
ConsensusPathDB
Pathway Commons: MUC7
MetabolismMetaCyc: MUC7
HUMANCyc: MUC7
RegulationEnsembl's Regulation: ENSG00000171195
miRBase: chr4 :71,337,833-71,348,714
TargetScan: NM_001145006
cisRED: ENSG00000171195
ContextiHOP: MUC7
cancer metabolism search in PubMed: MUC7
UCL Cancer Institute: MUC7
Assigned class in ccmGDBC

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Phenotypic Information for MUC7(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MUC7
Familial Cancer Database: MUC7
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: MUC7
MedGen: MUC7 (Human Medical Genetics with Condition)
ClinVar: MUC7
PhenotypeMGI: MUC7 (International Mouse Phenotyping Consortium)
PhenomicDB: MUC7

Mutations for MUC7
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MUC7 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BX487918MALAT12320116526651665266834MUC731445147134688571347022
BX487700MALAT12379116526651665266893MUC737462747133973871346714
BX537739CUL9149764314997143150467MUC7490251647134668871348714

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=9

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=87)
Stat. for Synonymous SNVs
(# total SNVs=17)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=1)
There's no deleted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr4:71347185-71347185p.S242P9
chr4:71346978-71346978p.S173P9
chr4:71347138-71347138p.P226L4
chr4:71347033-71347033p.A191V4
chr4:71347047-71347047p.S196P4
chr4:71346646-71346646p.S62F3
chr4:71347171-71347171p.A237V3
chr4:71347291-71347291p.P277L3
chr4:71346827-71346827p.K122K3
chr4:71347468-71347468p.S336L3

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=6

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample34 142 4 4  2244  198511
# mutation44 112 4 4  2444  17959
nonsynonymous SNV33 91 3 3  2232  16548
synonymous SNV11 31 1 1  212  1411
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr4:71347185p.S242P,MUC76
chr4:71346978p.S173P,MUC75
chr4:71347138p.P226L,MUC74
chr4:71347468p.S62F,MUC73
chr4:71346827p.K122N,MUC73
chr4:71347033p.S297Y,MUC73
chr4:71346646p.S336L,MUC73
chr4:71347351p.A191V,MUC73
chr4:71346820p.R358Q,MUC72
chr4:71347020p.S196P,MUC72

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MUC7 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MUC7

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

C15orf41,C1QL3,BPIFB3,CACNA1A,CAT,CD44,CYP7A1,
DMBT1,GPR85,MROH2B,KCNS1,MEIS2,MRGPRG,MUC7,
OR7E156P,PLA2R1,PRM3,RBM44,RHD,TNFRSF11B,UTS2
C1orf194,C20orf85,CACNG3,CDC20B,CDC6,EPGN,GABRA3,
KRT12,KRT20,MAGEC1,MUC7,OR2T11,OR5M11,OR6C65,
OR6C76,OR6N2,SOX11,TEKT1,TMIGD1,TTTY23,ZBBX

TRAPPC3L,BSND,CABP1,CCL25,CDK6,FAM99A,FOXI1,
GOLGA7B,KRT74,MUC7,LINC00028,NEUROD6,ODAM,PHACTR1,
PTPRO,RAG2,SPP2,SULT1E1,SYT8,TCF7,TNNI2
AGRP,C10orf91,C16orf92,CT45A5,FLJ46361,H2BFM,IL31,
LHX1,LOC221122,LOC727924,MMP26,MUC7,LINC00112,OLIG2,
OR51B2,OR6X1,PRAMEF16,PRM2,PSG7,SCARNA21,SNORA11E,
TMPRSS12
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MUC7


There's no related Drug.
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Cross referenced IDs for MUC7
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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