Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for NFYB

Basic gene info.	Gene symbol	NFYB
	Gene name	nuclear transcription factor Y, beta
	Synonyms	CBF-A\|CBF-B\|HAP3\|NF-YB
	Cytomap	UCSC genome browser: 12q22-q23
	Genomic location	chr12 :104510857-104532040
	Type of gene	protein-coding
	RefGenes	NM_006166.3,
	Ensembl id	ENSG00000120837
	Description	CAAT box DNA-binding protein subunit BCCAAT-binding transcription factor subunit ATranscription factor NF-Y, B subunitnuclear transcription factor Y subunit Bnuclear transcription factor Y subunit beta
	Modification date	20141207
dbXrefs	MIM : 189904
	HGNC : HGNC
	Ensembl : ENSG00000120837
	HPRD : 01794
	Vega : OTTHUMG00000170176
Protein	UniProt: P25208 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_NFYB
	BioGPS: 4801
	Gene Expression Atlas: ENSG00000120837
	The Human Protein Atlas: ENSG00000120837
Pathway	NCI Pathway Interaction Database: NFYB
	KEGG: NFYB
	REACTOME: NFYB
	ConsensusPathDB
	Pathway Commons: NFYB
Metabolism	MetaCyc: NFYB
	HUMANCyc: NFYB
Regulation	Ensembl's Regulation: ENSG00000120837
	miRBase: chr12 :104,510,857-104,532,040
	TargetScan: NM_006166
	cisRED: ENSG00000120837
Context	iHOP: NFYB
	cancer metabolism search in PubMed: NFYB
	UCL Cancer Institute: NFYB
Assigned class in ccmGDB	B - This gene belongs to cancer gene.

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Phenotypic Information for NFYB(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: NFYB
	Familial Cancer Database: NFYB

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

Others
OMIM	189904; gene.
Orphanet
Disease	KEGG Disease: NFYB
	MedGen: NFYB (Human Medical Genetics with Condition)
	ClinVar: NFYB
Phenotype	MGI: NFYB (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: NFYB

Mutations for NFYB

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NFYB related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
BG427715	BRCA1	2	172	17	41277618	41277789	NFYB	170	704	12	104515074	104529311
AL043727	NFYB	1	412	12	104510880	104511290	DNAH1	402	635	3	52354666	52354900

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

There's no copy number variation information in COSMIC data for this gene.

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=1

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=10)	Stat. for Synonymous SNVs (# total SNVs=2)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr12:104519903-104519903	p.Q74*	1
chr12:104517017-104517017	p.Q139R	1
chr12:104519919-104519919	p.M68I	1
chr12:104517031-104517031	p.L134L	1
chr12:104519950-104519950	p.Y58S	1
chr12:104517046-104517046	p.S129R	1
chr12:104519998-104519998	p.H42R	1
chr12:104517051-104517051	p.D128N	1
chr12:104520007-104520007	p.M39T	1
chr12:104517081-104517081	p.I118V	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		1		2	1							1					3			2
# mutation		1		2	1							1					3			2
nonsynonymous SNV				2	1							1					3			2
synonymous SNV		1

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr12:104517017	p.L134L	1
chr12:104517031	p.S129R	1
chr12:104517046	p.I118V	1
chr12:104517081	p.A101G	1
chr12:104517131	p.M68I	1
chr12:104519919	p.H42R	1
chr12:104519998	p.M39T	1
chr12:104520007	p.G183C	1
chr12:104514222	p.G177C	1
chr12:104514240	p.Q139R	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for NFYB in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for NFYB

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ACTR6,BRAP,PARPBP,DEPDC4,IFT81,METAP2,MRPL42, NFYB,NR2C1,NUP37,POLR3B,PPP1CC,PWP1,RFC5, RSRC2,SUDS3,TDG,TMPO,UBE2N,ZNF140,ZNF84	ATG5,CLDND1,DEK,FBXL3,GABPA,HMGB1,KDSR, LIN7C,MIER1,NFYB,PCGF5,PCNP,BLOC1S6,PLEKHA3, RNF219,SREK1IP1,SMNDC1,SYPL1,TROVE2,TWSG1,UBE2Q2

AEBP2,BBS10,ARL14EP,CCAR1,CEP83,CCDC59,CDK17, DENR,MDM1,MPHOSPH10,NAP1L1,NEDD1,NFYB,PCGF6, PPHLN1,PPP1R12A,TCEAL4,YAF2,ZCRB1,ZDHHC17,ZNF140	ASB5,B3GALNT1,BRMS1L,CCDC169,FAM229B,CFAP36,EIF5A2, FGF10,FYTTD1,GNB4,HDGFRP3,IL33,LOC399959,LOH12CR2, NFYB,NME4,REXO2,SNCA,SOX2-OT,TMEM74,TPD52L1

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for NFYB

There's no related Drug.

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Cross referenced IDs for NFYB

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information