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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for NOS2 |
Basic gene info. | Gene symbol | NOS2 |
Gene name | nitric oxide synthase 2, inducible | |
Synonyms | HEP-NOS|INOS|NOS|NOS2A | |
Cytomap | UCSC genome browser: 17q11.2 | |
Genomic location | chr17 :26083791-26127555 | |
Type of gene | protein-coding | |
RefGenes | NM_000625.4, NM_153292.1, | |
Ensembl id | ENSG00000007171 | |
Description | NOS type IINOS, type IIhepatocyte NOSinducible NO synthaseinducible NOSnitric oxide synthase 2A (inducible, hepatocytes)nitric oxide synthase, induciblenitric oxide synthase, macrophagepeptidyl-cysteine S-nitrosylase NOS2 | |
Modification date | 20141222 | |
dbXrefs | MIM : 163730 | |
HGNC : HGNC | ||
Ensembl : ENSG00000007171 | ||
HPRD : 01225 | ||
Vega : OTTHUMG00000132445 | ||
Protein | UniProt: P35228 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NOS2 | |
BioGPS: 4843 | ||
Gene Expression Atlas: ENSG00000007171 | ||
The Human Protein Atlas: ENSG00000007171 | ||
Pathway | NCI Pathway Interaction Database: NOS2 | |
KEGG: NOS2 | ||
REACTOME: NOS2 | ||
ConsensusPathDB | ||
Pathway Commons: NOS2 | ||
Metabolism | MetaCyc: NOS2 | |
HUMANCyc: NOS2 | ||
Regulation | Ensembl's Regulation: ENSG00000007171 | |
miRBase: chr17 :26,083,791-26,127,555 | ||
TargetScan: NM_000625 | ||
cisRED: ENSG00000007171 | ||
Context | iHOP: NOS2 | |
cancer metabolism search in PubMed: NOS2 | ||
UCL Cancer Institute: NOS2 | ||
Assigned class in ccmGDB | A - This gene has a literature evidence and it belongs to cancer gene. | |
References showing role of NOS2 in cancer cell metabolism | 1. Gerner E (2007) Impact of dietary amino acids and polyamines on intestinal carcinogenesis and chemoprevention in mouse models. Biochemical Society Transactions 35: 322. go to article |
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Phenotypic Information for NOS2(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: NOS2 |
Familial Cancer Database: NOS2 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_ARGININE_AND_PROLINE_METABOLISM |
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OMIM | 163730; gene. 163730; gene. 611162; phenotype. 611162; phenotype. |
Orphanet | |
Disease | KEGG Disease: NOS2 |
MedGen: NOS2 (Human Medical Genetics with Condition) | |
ClinVar: NOS2 | |
Phenotype | MGI: NOS2 (International Mouse Phenotyping Consortium) |
PhenomicDB: NOS2 |
Mutations for NOS2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
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- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | NOS2 | chr17 | 26093777 | 26093797 | chr6 | 106805874 | 106805894 | |
pancreas | NOS2 | chr17 | 26120487 | 26120507 | NOS2 | chr17 | 26120755 | 26120775 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NOS2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AK310926 | NOS2 | 1 | 2388 | 17 | 26097938 | 26220391 | TTC37 | 2386 | 3633 | 5 | 94800124 | 94830723 | |
BF844302 | ZDHHC3 | 17 | 79 | 3 | 44968976 | 44969038 | NOS2 | 75 | 259 | 17 | 26218020 | 26218204 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 3 |   |   |   |   |   | 1 |   | 2 |   | 2 |   |   |   |   |   | 1 | |||
GAIN (# sample) | 3 |   |   |   |   |   | 1 |   | 1 |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   | 1 |   | 1 |   |   |   |   |   | 1 |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=102) | (# total SNVs=28) |
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(# total SNVs=3) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr17:26114738-26114738 | p.E145K | 3 |
chr17:26094815-26094815 | p.P695S | 2 |
chr17:26086080-26086080 | p.R1061R | 2 |
chr17:26093539-26093539 | p.S748F | 2 |
chr17:26108129-26108129 | p.R266H | 2 |
chr17:26099431-26099431 | p.R536Q | 2 |
chr17:26089931-26089931 | p.S898F | 2 |
chr17:26108182-26108182 | p.P248P | 2 |
chr17:26110016-26110016 | p.R195H | 2 |
chr17:26107839-26107839 | p.E320K | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 4 | 6 | 1 | 8 | 2 |   | 9 |   | 3 |   | 1 | 25 | 7 | 1 | 1 |   | 12 | 12 |   | 13 |
# mutation | 4 | 6 | 1 | 10 | 2 |   | 9 |   | 3 |   | 1 | 25 | 7 | 1 | 1 |   | 18 | 15 |   | 16 |
nonsynonymous SNV | 3 | 5 | 1 | 7 | 1 |   | 6 |   | 2 |   | 1 | 17 | 5 | 1 |   |   | 12 | 7 |   | 14 |
synonymous SNV | 1 | 1 |   | 3 | 1 |   | 3 |   | 1 |   |   | 9 | 2 |   | 1 |   | 6 | 8 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr17:26114738 | p.E145K | 2 |
chr17:26093545 | p.R1061R | 2 |
chr17:26086080 | p.P746L | 2 |
chr17:26089931 | p.S898F | 2 |
chr17:26092683 | p.P248S | 1 |
chr17:26101433 | p.A1092V | 1 |
chr17:26109099 | p.V147V | 1 |
chr17:26085934 | p.E860D | 1 |
chr17:26094858 | p.P57L | 1 |
chr17:26106012 | p.R670R | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for NOS2 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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ACAN,BGN,C1orf177,NPR3,ENPEP,FGFBP2,FRZB, FXYD4,GSTTP2,LCTL,LOC643008,NOS2,PANX3,PHOSPHO1, PRELP,PRSS54,RNF175,SCRG1,SLC6A18,USH1G,WWP2 | AKAP1,ARIH2,C14orf39,CDNF,COL4A3,CPT1B,GBX1, GRIP2,INCA1,KLHL21,MEF2D,NOS2,OIT3,PAIP2B, PLCD4,PPARGC1A,PYGO1,RPUSD4,TMIE,TRAK1,USP19 | ||||
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BCL3,C17orf78,CASP10,CASP5,CEACAM20,CFB,DUOX2, DUOXA2,HK2,INSC,LOC286002,MMP10,NFKBIZ,NLRP6, NOS2,REG3G,SOCS1,TNIP3,TRIM40,XDH,ZC3H12A | APOL1,ASS1,BACE2,BATF2,CALR,CASP5,CLEC6A, CRELD2,FAM26F,GRAMD2,GZMB,IFI30,IFITM1,LYPD5, NOS2,PARP9,PSMB2,PSME2,RTEL1,STAT1,UBE2L6 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for NOS2 |
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DB Category | DB Name | DB's ID and Url link |
Chemistry | BindingDB | P35228; -. |
Chemistry | ChEMBL | CHEMBL2096621; -. |
Chemistry | GuidetoPHARMACOLOGY | 1250; -. |
Chemistry | BindingDB | P35228; -. |
Chemistry | ChEMBL | CHEMBL2096621; -. |
Chemistry | GuidetoPHARMACOLOGY | 1250; -. |
Organism-specific databases | PharmGKB | PA164724093; -. |
Organism-specific databases | PharmGKB | PA164724093; -. |
Organism-specific databases | CTD | 4843; -. |
Organism-specific databases | CTD | 4843; -. |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00125 | nitric oxide synthase 2, inducible | approved; nutraceutical | L-Arginine | ![]() | ![]() |
DB00155 | nitric oxide synthase 2, inducible | approved; nutraceutical | L-Citrulline | ![]() | ![]() |
DB01110 | nitric oxide synthase 2, inducible | approved; investigational | Miconazole | ![]() | ![]() |
DB01234 | nitric oxide synthase 2, inducible | approved; investigational | Dexamethasone | ![]() | ![]() |
DB01686 | nitric oxide synthase 2, inducible | experimental | N,N-dimethylarginine | ![]() | ![]() |
DB01835 | nitric oxide synthase 2, inducible | experimental | 4r-Fluoro-N6-Ethanimidoyl-L-Lysine | ![]() | ![]() |
DB01997 | nitric oxide synthase 2, inducible | experimental | 3-Bromo-7-Nitroindazole | ![]() | ![]() |
DB02044 | nitric oxide synthase 2, inducible | experimental | N-(3-(Aminomethyl)Benzyl)Acetamidine | ![]() | ![]() |
DB02207 | nitric oxide synthase 2, inducible | experimental | 7-Nitroindazole | ![]() | ![]() |
DB02234 | nitric oxide synthase 2, inducible | experimental | Ethylisothiourea | ![]() | ![]() |
DB02462 | nitric oxide synthase 2, inducible | experimental | Thiocoumarin | ![]() | ![]() |
DB02533 | nitric oxide synthase 2, inducible | experimental | Aminoguanidine | ![]() | ![]() |
DB02539 | nitric oxide synthase 2, inducible | experimental | S-Ethylisothiourea | ![]() | ![]() |
DB02644 | nitric oxide synthase 2, inducible | experimental | N-Omega-Propyl-L-Arginine | ![]() | ![]() |
DB02692 | nitric oxide synthase 2, inducible | experimental | (6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin | ![]() | ![]() |
DB03014 | nitric oxide synthase 2, inducible | experimental | Heme | ![]() | ![]() |
DB03100 | nitric oxide synthase 2, inducible | experimental | 6-Nitroindazole | ![]() | ![]() |
DB03144 | nitric oxide synthase 2, inducible | experimental | N-Omega-Hydroxy-L-Arginine | ![]() | ![]() |
DB03271 | nitric oxide synthase 2, inducible | experimental | 7,8-Dihydro-L-Biopterin | ![]() | ![]() |
DB03449 | nitric oxide synthase 2, inducible | experimental | N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine | ![]() | ![]() |
DB03953 | nitric oxide synthase 2, inducible | experimental | L-Thiocitrulline | ![]() | ![]() |
DB04400 | nitric oxide synthase 2, inducible | experimental | 7,8-Dihydrobiopterin | ![]() | ![]() |
DB04534 | nitric oxide synthase 2, inducible | experimental | 5-Nitroindazole | ![]() | ![]() |
DB06879 | nitric oxide synthase 2, inducible | experimental | 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE | ![]() | ![]() |
DB06916 | nitric oxide synthase 2, inducible | experimental | N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE | ![]() | ![]() |
DB07002 | nitric oxide synthase 2, inducible | experimental | 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile | ![]() | ![]() |
DB07003 | nitric oxide synthase 2, inducible | experimental | (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine | ![]() | ![]() |
DB07007 | nitric oxide synthase 2, inducible | experimental | (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine | ![]() | ![]() |
DB07008 | nitric oxide synthase 2, inducible | experimental | 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE | ![]() | ![]() |
DB07011 | nitric oxide synthase 2, inducible | experimental | (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE | ![]() | ![]() |
DB07029 | nitric oxide synthase 2, inducible | experimental | 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE | ![]() | ![]() |
DB07306 | nitric oxide synthase 2, inducible | experimental | ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE | ![]() | ![]() |
DB07318 | nitric oxide synthase 2, inducible | experimental | N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE | ![]() | ![]() |
DB07388 | nitric oxide synthase 2, inducible | experimental | ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE | ![]() | ![]() |
DB07389 | nitric oxide synthase 2, inducible | experimental | N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE | ![]() | ![]() |
DB07405 | nitric oxide synthase 2, inducible | experimental | 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE | ![]() | ![]() |
DB08214 | nitric oxide synthase 2, inducible | experimental | 4-(1H-IMIDAZOL-1-YL)PHENOL | ![]() | ![]() |
DB08750 | nitric oxide synthase 2, inducible | experimental | 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE | ![]() | ![]() |
DB00997 | nitric oxide synthase 2, inducible | approved; investigational | Doxorubicin | ![]() | ![]() |
DB00435 | nitric oxide synthase 2, inducible | approved | Nitric Oxide | ![]() | ![]() |
DB00227 | nitric oxide synthase 2, inducible | approved; investigational | Lovastatin | ![]() | ![]() |
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Cross referenced IDs for NOS2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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