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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for NT5E |
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Phenotypic Information for NT5E(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: NT5E |
Familial Cancer Database: NT5E |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_PURINE_METABOLISM KEGG_PYRIMIDINE_METABOLISM KEGG_NICOTINATE_AND_NICOTINAMIDE_METABOLISM REACTOME_METABOLISM_OF_NUCLEOTIDES REACTOME_PURINE_METABOLISM REACTOME_PYRIMIDINE_METABOLISM |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: NT5E |
MedGen: NT5E (Human Medical Genetics with Condition) | |
ClinVar: NT5E | |
Phenotype | MGI: NT5E (International Mouse Phenotyping Consortium) |
PhenomicDB: NT5E |
Mutations for NT5E |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | NT5E | chr6 | 86165761 | 86165781 | chr6 | 85552682 | 85552702 | |
ovary | NT5E | chr6 | 86170986 | 86171006 | NT5E | chr6 | 86166993 | 86167013 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NT5E related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BU622781 | TTC7B | 2 | 75 | 14 | 91233316 | 91233389 | NT5E | 68 | 644 | 6 | 86201732 | 86203971 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   | 1 |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   | 1 |   |   |   |   |   |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=45) | (# total SNVs=14) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr6:86197130-86197130 | p.I343V | 2 |
chr6:86159948-86159948 | p.I31V | 2 |
chr6:86160088-86160088 | p.N77K | 2 |
chr6:86195018-86195018 | p.R273W | 2 |
chr6:86195099-86195099 | p.V300I | 2 |
chr6:86181079-86181079 | p.I229I | 2 |
chr6:86181089-86181089 | p.V233M | 1 |
chr6:86200256-86200256 | p.V414A | 1 |
chr6:86194989-86194989 | p.Y263F | 1 |
chr6:86201753-86201753 | p.D473D | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 6 |   | 8 | 3 |   | 1 |   |   |   |   | 4 | 6 | 3 |   |   | 8 | 3 | 1 | 5 |
# mutation | 3 | 6 |   | 8 | 3 |   | 1 |   |   |   |   | 4 | 6 | 3 |   |   | 8 | 3 | 1 | 5 |
nonsynonymous SNV | 3 | 5 |   | 6 | 2 |   |   |   |   |   |   | 4 | 2 | 2 |   |   | 4 |   | 1 | 5 |
synonymous SNV |   | 1 |   | 2 | 1 |   | 1 |   |   |   |   |   | 4 | 1 |   |   | 4 | 3 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr6:86197130 | p.I229I,NT5E | 2 |
chr6:86203631 | p.R495Q,NT5E | 2 |
chr6:86195018 | p.R273W,NT5E | 2 |
chr6:86181079 | p.I343V,NT5E | 2 |
chr6:86200329 | p.L228L,NT5E | 1 |
chr6:86181095 | p.S349S,NT5E | 1 |
chr6:86197131 | p.M439I,NT5E | 1 |
chr6:86159901 | p.Q351E,NT5E | 1 |
chr6:86200337 | p.E441K,NT5E | 1 |
chr6:86181103 | p.Q231H,NT5E | 1 |
Other DBs for Point Mutations |
Copy Number for NT5E in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for NT5E |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACTN1,ADAM19,ALPK2,ANTXR2,ARPC2,AXL,CALD1, CFH,CHST11,DSE,FAM26E,LAMC2,LOX,NRP2, NT5E,OLFML1,PLAU,PLS3,SRPX,TIMP2,TPST1 | ABI3BP,C1S,ACKR4___CX3CR1,CLIC2,ACKR3,DCN,DPP4, DPYSL3,GALNT12,GPR133,LPAR1,MFAP4,NOX4,NT5E, OLFML1,OMD,PAM,PRRX1,PTGIS,TIMP2,TPST1 | ||||
AQP6,CLEC18A,CLEC18B,CLEC18C,CXorf49B,DMRTB1,SLC25A3P1, INPP5K,LCK,LOC388242,NT5E,PRG2,psiTPTE22,RGS17, RMST,S100A13,SAV1,TDH,TM4SF1,WIPF3,WNT16 | ATP6AP1,GID8,CCDC122,CCNJL,CHAD,DIO3,DIO3OS, ERGIC1,GATA6,ISX,ITPKA,NT5E,NUDT14,PCBP2, PCK1,RUNDC3B,SNX15,TMEM98,USP30,VSIG10,ZNF763 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for NT5E |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00806 | 5'-nucleotidase, ecto (CD73) | approved; investigational | Pentoxifylline | ||
DB00640 | 5'-nucleotidase, ecto (CD73) | approved; investigational | Adenosine | ||
DB02745 | 5'-nucleotidase, ecto (CD73) | experimental | Uridine | ||
DB00352 | 5'-nucleotidase, ecto (CD73) | approved | Thioguanine | ||
DB01033 | 5'-nucleotidase, ecto (CD73) | approved | Mercaptopurine | ||
DB01120 | 5'-nucleotidase, ecto (CD73) | approved | Gliclazide | ||
DB00563 | 5'-nucleotidase, ecto (CD73) | approved | Methotrexate | ||
DB00795 | 5'-nucleotidase, ecto (CD73) | approved | Sulfasalazine | ||
DB02010 | 5'-nucleotidase, ecto (CD73) | experimental | Staurosporine |
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Cross referenced IDs for NT5E |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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