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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for OAZ1 |
Basic gene info. | Gene symbol | OAZ1 |
Gene name | ornithine decarboxylase antizyme 1 | |
Synonyms | AZI|OAZ | |
Cytomap | UCSC genome browser: 19p13.3 | |
Genomic location | chr19 :2269519-2273487 | |
Type of gene | protein-coding | |
RefGenes | NM_001301020.1, NM_004152.3, | |
Ensembl id | ENSG00000104904 | |
Description | ODC-Azantizyme 1 | |
Modification date | 20141216 | |
dbXrefs | MIM : 601579 | |
HGNC : HGNC | ||
Ensembl : ENSG00000104904 | ||
HPRD : 03346 | ||
Vega : OTTHUMG00000178459 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OAZ1 | |
BioGPS: 4946 | ||
Gene Expression Atlas: ENSG00000104904 | ||
The Human Protein Atlas: ENSG00000104904 | ||
Pathway | NCI Pathway Interaction Database: OAZ1 | |
KEGG: OAZ1 | ||
REACTOME: OAZ1 | ||
ConsensusPathDB | ||
Pathway Commons: OAZ1 | ||
Metabolism | MetaCyc: OAZ1 | |
HUMANCyc: OAZ1 | ||
Regulation | Ensembl's Regulation: ENSG00000104904 | |
miRBase: chr19 :2,269,519-2,273,487 | ||
TargetScan: NM_001301020 | ||
cisRED: ENSG00000104904 | ||
Context | iHOP: OAZ1 | |
cancer metabolism search in PubMed: OAZ1 | ||
UCL Cancer Institute: OAZ1 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for OAZ1(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: OAZ1 |
Familial Cancer Database: OAZ1 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: OAZ1 |
MedGen: OAZ1 (Human Medical Genetics with Condition) | |
ClinVar: OAZ1 | |
Phenotype | MGI: OAZ1 (International Mouse Phenotyping Consortium) |
PhenomicDB: OAZ1 |
Mutations for OAZ1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows OAZ1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CB153060 | OAZ1 | 4 | 228 | 19 | 2269520 | 2269744 | FKBP8 | 226 | 545 | 19 | 18652488 | 18652807 | |
DA327340 | OAZ1 | 1 | 59 | 19 | 2269519 | 2269577 | PLP1 | 60 | 556 | X | 103031802 | 103041577 | |
BU564747 | WIBG | 1 | 354 | 12 | 56295652 | 56296005 | OAZ1 | 342 | 449 | 19 | 2273131 | 2273238 | |
BC025017 | OAZ1 | 10 | 898 | 19 | 2269530 | 2273240 | TXNL1 | 897 | 2235 | 18 | 54270053 | 54318359 | |
BG315209 | OAZ1 | 1 | 92 | 19 | 2271822 | 2271913 | OAZ1 | 93 | 293 | 19 | 2273028 | 2273228 | |
AK098316 | OAZ1 | 1 | 224 | 19 | 2269520 | 2269743 | ULK2 | 223 | 3382 | 17 | 19679525 | 19769143 | |
DB259274 | OAZ1 | 1 | 224 | 19 | 2269520 | 2269743 | ULK2 | 223 | 585 | 17 | 19750068 | 19769143 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=4) | (# total SNVs=0) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr19:2271408-2271408 | p.C57* | 1 |
chr19:2271853-2271853 | p.L121V | 1 |
chr19:2272753-2272753 | p.F161I | 1 |
chr19:2272988-2272988 | p.F189V | 1 |
chr19:2273093-2273095 | p.E227delE | 1 |
chr19:2269637-2269637 | p.C14R | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
# mutation |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
nonsynonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
Other DBs for Point Mutations |
Copy Number for OAZ1 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for OAZ1 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ALKBH7,C19orf24,C19orf70,CLPP,DOHH,ABHD17A,LSM7, MAP2K2,MBD3,MRPL54,NCLN,NDUFA11,NDUFA13,NDUFB7, NDUFS7,OAZ1,PLEKHJ1,POLR2E,SIRT6,TIMM13,UQCR11 | ANAPC11,BLOC1S1,LAMTOR1,C19orf53,BABAM1,C19orf70,NAA38, MRPL53,NDUFA11,NDUFA13,NDUFAF3,NDUFB7,OAZ1,PNKD, POLD4,PSMB6,LAMTOR2,ROMO1,STUB1,URM1,ZMAT5 | ||||
ASNA1,C19orf25,C19orf53,CHCHD2,COPE,COX7A2,GADD45GIP1, GLRX3,GSTO1,LSM7,MRPL54,MRPS12,MYEOV2,NDUFA11, NDUFA13,NDUFB7,OAZ1,PIN1,PRDX2,UBL5,UQCR11 | ARF5,ATP6V0E1,BLOC1S1,LAMTOR1,COX14,TEN1,FAM32A, GUK1,JAGN1,NDUFA13,NDUFA2,OAZ1,POP4,NELFE, RNF181,RNF7,LAMTOR2,SDHAF2,SSNA1,TMEM219,UBL5 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for OAZ1 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00129 | ornithine decarboxylase antizyme 1 | approved; nutraceutical | L-Ornithine |
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Cross referenced IDs for OAZ1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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