Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for OAZ2

Basic gene info.	Gene symbol	OAZ2
	Gene name	ornithine decarboxylase antizyme 2
	Synonyms	AZ2
	Cytomap	UCSC genome browser: 15q22.31
	Genomic location	chr15 :64979772-64995462
	Type of gene	protein-coding
	RefGenes	NM_001301302.1, NM_002537.3,
	Ensembl id	ENSG00000180304
	Description	ODC-Az 2
	Modification date	20141216
dbXrefs	MIM : 604152
	HGNC : HGNC
	Ensembl : ENSG00000180304
	HPRD : 11966
	Vega : OTTHUMG00000172473
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_OAZ2
	BioGPS: 4947
	Gene Expression Atlas: ENSG00000180304
	The Human Protein Atlas: ENSG00000180304
Pathway	NCI Pathway Interaction Database: OAZ2
	KEGG: OAZ2
	REACTOME: OAZ2
	ConsensusPathDB
	Pathway Commons: OAZ2
Metabolism	MetaCyc: OAZ2
	HUMANCyc: OAZ2
Regulation	Ensembl's Regulation: ENSG00000180304
	miRBase: chr15 :64,979,772-64,995,462
	TargetScan: NM_001301302
	cisRED: ENSG00000180304
Context	iHOP: OAZ2
	cancer metabolism search in PubMed: OAZ2
	UCL Cancer Institute: OAZ2
Assigned class in ccmGDB	C

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Phenotypic Information for OAZ2(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: OAZ2
	Familial Cancer Database: OAZ2

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES

Others
OMIM
Orphanet
Disease	KEGG Disease: OAZ2
	MedGen: OAZ2 (Human Medical Genetics with Condition)
	ClinVar: OAZ2
Phenotype	MGI: OAZ2 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: OAZ2

Mutations for OAZ2

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows OAZ2 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
W51772	OAZ2	2	464	15	64980835	64982750	LOC100499227	460	648	11	119288891	119289085
DA674180	OAZ2	1	187	15	64995228	64995414	SMARCC1	186	589	3	47663756	47680272
AI090341	LOC100499227	31	224	11	119288891	119289085	OAZ2	220	485	15	64980835	64981349
W26817	OAZ2	13	184	15	64980752	64980923	OAZ2	182	450	15	64980482	64980750

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=1

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=7)	Stat. for Synonymous SNVs (# total SNVs=2)

Stat. for Deletions (# total SNVs=1)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr15:64980914-64980914	p.D187N	1
chr15:64983649-64983650	p.A55fs*4	1
chr15:64980940-64980940	p.V178G	1
chr15:64983701-64983701	p.P37S	1
chr15:64980952-64980952	p.V174A	1
chr15:64995230-64995230	p.D6E	1
chr15:64980958-64980958	p.P172R	1
chr15:64981323-64981323	p.N133K	1
chr15:64982618-64982618	p.F103S	1
chr15:64982648-64982648	p.W93L	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=0

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample
# mutation
nonsynonymous SNV
synonymous SNV

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position

Mutation(aa)

Unique sampleID count

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for OAZ2 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for OAZ2

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ANP32A,APH1B,FAM219B,VWA9,DIS3L,FAM96A,IMP3, MAP2K5,MTFMT,OAZ2,PARP16,PDCD7,PPIB,RAB11A, RPL4,SNAPC5,SNX1,SPG21,SRP14,TRIP4,UBL7	CARM1,DBNDD2,DEXI,CTDNEP1,FAM89B,HCFC1R1,HOMER3, KEAP1,MRPL14,NOSIP,NXN,OAZ2,PDLIM2,PKM, RILPL1,SEPW1,SLC35E4,TFEB,TOMM40L,UBAC1,UBL4A

ATP8B2,C1R,CLEC14A,CNRIP1,CSRP2,ECSCR,FBXL7, GNAI2,GNB4,GYPC,KCNJ8,KIF17,KLHL5,LAYN, LRRC8C,OAZ2,PECAM1,PLEKHO1,PLEKHO2,S1PR1,SYT11	BEX4,C9orf9,CLUAP1,CNRIP1,CRTAP,DNAJC18,DPF2, GYPC,OAZ2,PJA1,PLSCR3,PRDM8,RAB34,RGS10, RPL23AP82,SH3BGRL,SMARCD3,TMEM55A,TNFSF12,TRAM1L1,TRIM23

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for OAZ2

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00129	ornithine decarboxylase antizyme 2	approved; nutraceutical	L-Ornithine

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Cross referenced IDs for OAZ2

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information