Cancer Cell Metabolism Gene Database

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for FURIN
Basic gene info.Gene symbolFURIN
Gene namefurin (paired basic amino acid cleaving enzyme)
SynonymsFUR|PACE|PCSK3|SPC1
CytomapUCSC genome browser: 15q26.1
Genomic locationchr15 :91411884-91426687
Type of geneprotein-coding
RefGenesNM_001289823.1,
NM_001289824.1,NM_002569.3,
Ensembl idENSG00000140564
DescriptionFES upstream regiondibasic processing enzymefurinfurin, membrane associated receptor proteinpaired basic amino acid residue-cleaving enzymeproprotein convertase subtilisin/kexin type 3
Modification date20141207
dbXrefs MIM : 136950
HGNC : HGNC
Ensembl : ENSG00000140564
HPRD : 00653
Vega : OTTHUMG00000149831
ProteinUniProt: P09958
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FURIN
BioGPS: 5045
Gene Expression Atlas: ENSG00000140564
The Human Protein Atlas: ENSG00000140564
PathwayNCI Pathway Interaction Database: FURIN
KEGG: FURIN
REACTOME: FURIN
ConsensusPathDB
Pathway Commons: FURIN
MetabolismMetaCyc: FURIN
HUMANCyc: FURIN
RegulationEnsembl's Regulation: ENSG00000140564
miRBase: chr15 :91,411,884-91,426,687
TargetScan: NM_001289823
cisRED: ENSG00000140564
ContextiHOP: FURIN
cancer metabolism search in PubMed: FURIN
UCL Cancer Institute: FURIN
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for FURIN(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: FURIN
Familial Cancer Database: FURIN
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_PROTEINS

check002.gifOthers
OMIM 136950; gene.
Orphanet
DiseaseKEGG Disease: FURIN
MedGen: FURIN (Human Medical Genetics with Condition)
ClinVar: FURIN
PhenotypeMGI: FURIN (International Mouse Phenotyping Consortium)
PhenomicDB: FURIN

Mutations for FURIN
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
There's no intra-chromosomal structural variation.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows FURIN related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
BF986802FURIN1110159141976891420215FURIN107196159141911991419545
CK822852FURIN1122159142480191424922FLOT2120206172720715127207237
BE812237FURIN1266159142554891425809COTL1267407168460029084600430
BF990968SLCO2B111166117486926974869423FURIN160255159142293391423120
CK822851FLOT2153172720715127207203FURIN51183159142480191424933
CB163740C311361966778496677984FURIN137516159142591891426297
AI418492FURIN12174159142652691426688PCNXL3170580116540244265402949
BQ102242FLOT2153172720715127207203FURIN51183159142480191424933
BQ102508FURIN1122159142480191424922FLOT2120206172720715127207237
BG004887FURIN1212159141976891420429FURIN209298159141911991419545
R59927COX6C131868100890377100899775FURIN173412159142591891426152
BG004888FURIN11192159141976891420397FURIN189282159141911991419549
BF823726FURIN1147159141975491420238ANKRD11131317168934838089348578
BG924324FURIN97280159142650491426687TNFSF12-TNFSF132766641774624607463472
T10274COX6C31768100890377100899775FURIN163309159142600691426152
BF959423FURIN1201159142271691423136FURIN196408159142345491424197

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=52)
Stat. for Synonymous SNVs
(# total SNVs=27)
Stat. for Deletions
(# total SNVs=7)
Stat. for Insertions
(# total SNVs=2)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr15:91424574-91424574p.G617G4
chr15:91424898-91424898p.I725I3
chr15:91424957-91424957p.R745L3
chr15:91425058-91425058p.E779K2
chr15:91424619-91424619p.D632D2
chr15:91423413-91423413p.A489V2
chr15:91425068-91425068p.G782fs*>132
chr15:91424910-91424910p.F729F2
chr15:91425099-91425099p.S792S2
chr15:91419739-91419739p.D108D2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample34 143 1 1  9321 86 7
# mutation34 153 1 1  10321 107 7
nonsynonymous SNV21 122 1    8111 64 5
synonymous SNV13 31   1  221  43 2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr15:91424898p.I725I,FURIN2
chr15:91419549p.R677Q,FURIN1
chr15:91423440p.R83L,FURIN1
chr15:91424619p.L269L,FURIN1
chr15:91420789p.S524S,FURIN1
chr15:91424939p.T554I,FURIN1
chr15:91422758p.S685S,FURIN1
chr15:91423936p.V100G,FURIN1
chr15:91419555p.G277W,FURIN1
chr15:91424646p.K565T,FURIN1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for FURIN in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for FURIN

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AEN,ST20-AS1,VWA7,DAND5,FURIN,GPR26,HDDC3,
IRS2,MAN2A2,OR4C11,PKM,POLG,RASA4P,RCCD1,
RSPO1,SLCO3A1,SMOC1,UNC45A,VWA1,WT1-AS,WT1
AP1M1,ASCC2,COL4A2,EFNB1,FURIN,GPX4,IMPDH1,
INF2,CTIF,KIFC3,LDLRAD2,LOC80054,LZTR1,NADK,
PALM,PHLDA3,POLR2E,POR,PRR5,ST6GALNAC6,TESK1

AKAP13,ARHGAP22,BCAR1,CD276,CKAP4,FURIN,HPN,
IL4R,KDM6B,KIF19,KLK12,LRP10,MAPRE2,MESDC1,
PHLDB3,PPARD,SCN1B,SPINT1,TJP1,TRAM2,ZNF407
ATG2A,BCAR1,C6orf132,CDC42BPG,CTDP1,EDC4,FURIN,
INF2,ITGA3,ITGB4,MAP3K11,MYH14,OS9,PCNXL3,
PLXNB2,PPP1R13L,PRKD2,PXN,CAPN15,TRIM11,WWP2
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for FURIN
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P09958; -.
ChemistryChEMBL CHEMBL2611; -.
ChemistryGuidetoPHARMACOLOGY 2366; -.
Organism-specific databasesPharmGKB PA32894; -.
Organism-specific databasesCTD 5045; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB03600furin (paired basic amino acid cleaving enzyme)experimentalDecanoic Acid


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Cross referenced IDs for FURIN
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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