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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ACOX1 |
Basic gene info. | Gene symbol | ACOX1 |
Gene name | acyl-CoA oxidase 1, palmitoyl | |
Synonyms | ACOX|PALMCOX|SCOX | |
Cytomap | UCSC genome browser: 17q25.1 | |
Genomic location | chr17 :73937588-73975515 | |
Type of gene | protein-coding | |
RefGenes | NM_001185039.1, NM_004035.6,NM_007292.5, | |
Ensembl id | ENSG00000161533 | |
Description | AOXacyl-CoA oxidase, straight-chainacyl-Coenzyme A oxidase 1, palmitoylpalmitoyl-CoA oxidaseperoxisomal acyl-coenzyme A oxidase 1peroxisomal fatty acyl-CoA oxidasestraight-chain acyl-CoA oxidase | |
Modification date | 20141207 | |
dbXrefs | MIM : 609751 | |
HGNC : HGNC | ||
Ensembl : ENSG00000161533 | ||
HPRD : 02030 | ||
Vega : OTTHUMG00000180027 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACOX1 | |
BioGPS: 51 | ||
Gene Expression Atlas: ENSG00000161533 | ||
The Human Protein Atlas: ENSG00000161533 | ||
Pathway | NCI Pathway Interaction Database: ACOX1 | |
KEGG: ACOX1 | ||
REACTOME: ACOX1 | ||
ConsensusPathDB | ||
Pathway Commons: ACOX1 | ||
Metabolism | MetaCyc: ACOX1 | |
HUMANCyc: ACOX1 | ||
Regulation | Ensembl's Regulation: ENSG00000161533 | |
miRBase: chr17 :73,937,588-73,975,515 | ||
TargetScan: NM_001185039 | ||
cisRED: ENSG00000161533 | ||
Context | iHOP: ACOX1 | |
cancer metabolism search in PubMed: ACOX1 | ||
UCL Cancer Institute: ACOX1 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for ACOX1(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ACOX1 |
Familial Cancer Database: ACOX1 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_FATTY_ACID_METABOLISM KEGG_ALPHA_LINOLENIC_ACID_METABOLISM REACTOME_PEROXISOMAL_LIPID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: ACOX1 |
MedGen: ACOX1 (Human Medical Genetics with Condition) | |
ClinVar: ACOX1 | |
Phenotype | MGI: ACOX1 (International Mouse Phenotyping Consortium) |
PhenomicDB: ACOX1 |
Mutations for ACOX1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | ACOX1 | chr17 | 73954633 | 73954653 | chr17 | 79840738 | 79840758 | |
pancreas | ACOX1 | chr17 | 73946071 | 73946271 | chr17 | 39853939 | 39854139 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ACOX1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AK310985 | GJA4 | 1 | 764 | 1 | 35258171 | 35260326 | ACOX1 | 765 | 1314 | 17 | 73945433 | 73947559 | |
AI766782 | ACOX1 | 30 | 190 | 17 | 73938959 | 73939119 | PRKAG2 | 184 | 327 | 7 | 151352004 | 151352146 | |
AA174053 | FAT3 | 1 | 167 | 11 | 92490864 | 92491030 | ACOX1 | 165 | 597 | 17 | 73971593 | 73972023 | |
AK025129 | TUG1 | 1 | 1600 | 22 | 31368887 | 31372067 | ACOX1 | 1588 | 1944 | 17 | 73970159 | 73970579 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) |   |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=34) | (# total SNVs=7) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr17:73945836-73945836 | p.E481K | 3 |
chr17:73945424-73945424 | p.V534V | 2 |
chr17:73949623-73949623 | p.L285F | 2 |
chr17:73945442-73945442 | p.? | 2 |
chr17:73944473-73944473 | p.L598L | 2 |
chr17:73944485-73944485 | p.E594D | 2 |
chr17:73949540-73949540 | p.I312M | 2 |
chr17:73945316-73945316 | p.N570N | 2 |
chr17:73945826-73945826 | p.T484I | 1 |
chr17:73951988-73951988 | p.L193L | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 2 |   | 7 |   |   |   |   | 1 | 1 |   | 3 | 3 | 1 |   |   | 9 | 7 |   | 6 |
# mutation | 3 | 2 |   | 7 |   |   |   |   | 1 | 1 |   | 4 | 2 | 1 |   |   | 9 | 8 |   | 6 |
nonsynonymous SNV | 1 | 2 |   | 7 |   |   |   |   | 1 | 1 |   | 4 | 1 | 1 |   |   | 5 | 5 |   | 5 |
synonymous SNV | 2 |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   | 4 | 3 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr17:73945836 | p.E443K,ACOX1 | 3 |
chr17:73945424 | p.V496V,ACOX1 | 2 |
chr17:73947627 | p.C411Y,ACOX1 | 1 |
chr17:73951917 | p.T184T,ACOX1 | 1 |
chr17:73974773 | p.T393T,ACOX1 | 1 |
chr17:73949563 | p.P179H,ACOX1 | 1 |
chr17:73944437 | p.F572L,ACOX1 | 1 |
chr17:73951930 | p.C366F,ACOX1 | 1 |
chr17:73945838 | p.G175W,ACOX1 | 1 |
chr17:73975104 | p.N532N,ACOX1 | 1 |
Other DBs for Point Mutations |
Copy Number for ACOX1 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ACOX1 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACOX1,ANKRD40,BPTF,CCDC47,DCAF7,EXOC7,GNA13, HELZ,LRRC59,MED13,MFSD11,MRPS7,NOL11,PRKAR1A, PRPSAP1,PSMD12,SPAG9,SRP68,STXBP4,TMEM104,UBE2O | ACO1,ACOX1,CLMP,ASPH,CAT,CD36,DDHD2, DMGDH,FERMT2,MMD,MRAS,PALM2-AKAP2,PCYOX1,PLIN1, PLOD2,SEPT11,SLC25A16,SORBS1,TSPAN3,VKORC1L1,WASF3 | ||||
ACOX1,AKAP1,ARHGAP27,C10orf99,CD24,CDH1,CDHR5, CEACAM5,ENTPD5,EPB41L4B,GPR39,HSD11B2,LLGL2,LRRC19, NR1I2,PCTP,PPP1R14D,RFFL,SGK2,SLC22A5,SLC35D1 | ACOX1,ALDH18A1,APLP2,APPL2,ATP1B1,CDKN2B,RHOV___CHP1, ENPP1,TMEM236,MARVELD3,MGLL,PHLPP2,PPARG,RELL1, RETSAT,RNF103,SFXN1,SLC22A5,SLC41A2,STBD1,VDAC1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for ACOX1 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB03147 | acyl-CoA oxidase 1, palmitoyl | experimental | Flavin-Adenine Dinucleotide | ||
DB07930 | acyl-CoA oxidase 1, palmitoyl | experimental | (3R)-3-HYDROXYDODECANOIC ACID | ||
DB01039 | acyl-CoA oxidase 1, palmitoyl | approved | Fenofibrate |
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Cross referenced IDs for ACOX1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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