Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for AZIN1
Basic gene info.Gene symbolAZIN1
Gene nameantizyme inhibitor 1
SynonymsAZI|AZIA1|OAZI|OAZIN|ODC1L
CytomapUCSC genome browser: 8q22.3
Genomic locationchr8 :103838535-103876397
Type of geneprotein-coding
RefGenesNM_001301668.1,
NM_015878.5,NM_148174.3,
Ensembl idENSG00000155096
Descriptionornithine decarboxylase antizyme inhibitor
Modification date20141207
dbXrefs MIM : 607909
HGNC : HGNC
Ensembl : ENSG00000155096
HPRD : 07443
Vega : OTTHUMG00000164766
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AZIN1
BioGPS: 51582
Gene Expression Atlas: ENSG00000155096
The Human Protein Atlas: ENSG00000155096
PathwayNCI Pathway Interaction Database: AZIN1
KEGG: AZIN1
REACTOME: AZIN1
ConsensusPathDB
Pathway Commons: AZIN1
MetabolismMetaCyc: AZIN1
HUMANCyc: AZIN1
RegulationEnsembl's Regulation: ENSG00000155096
miRBase: chr8 :103,838,535-103,876,397
TargetScan: NM_001301668
cisRED: ENSG00000155096
ContextiHOP: AZIN1
cancer metabolism search in PubMed: AZIN1
UCL Cancer Institute: AZIN1
Assigned class in ccmGDBC

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Phenotypic Information for AZIN1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: AZIN1
Familial Cancer Database: AZIN1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: AZIN1
MedGen: AZIN1 (Human Medical Genetics with Condition)
ClinVar: AZIN1
PhenotypeMGI: AZIN1 (International Mouse Phenotyping Consortium)
PhenomicDB: AZIN1

Mutations for AZIN1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryAZIN1chr8103851412103851432AZIN1chr8103851690103851710
ovaryAZIN1chr8103853364103853384AZIN1chr8103849438103849458
pancreasAZIN1chr8103852678103852698chr8103755378103755398
pancreasAZIN1chr8103852680103852700chr8103755378103755398
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AZIN1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
X76040LONP1130721956918465720138AZIN1307333948103839229103839550
DA410167TASP11224201352745413527677AZIN12235418103855779103870362
AA765801AZIN111168103876233103876348AEBP2111321121959279919593011
DA493026AZIN123278103876067103876392TRIM463245501155156687155156913
X74215LONP1127681956918465719834AZIN1276930908103839229103839550
DB135580YWHAZ11218101965496101965616AZIN11195498103851958103870380
AI890066COL6A1565214742395547424015AZIN1654918103838694103839120

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample4  1      1  1  2
GAIN (# sample)4  1      1  1  2
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=1

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=23)
Stat. for Synonymous SNVs
(# total SNVs=8)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr8:103851075-103851075p.Q116*2
chr8:103841572-103841572p.S388Y1
chr8:103845440-103845440p.H250N1
chr8:103851101-103851101p.N107S1
chr8:103841680-103841680p.S352T1
chr8:103846430-103846431p.F243fs*61
chr8:103851945-103851945p.C70Y1
chr8:103841709-103841709p.Y342Y1
chr8:103846950-103846950p.E204Q1
chr8:103851961-103851961p.F65L1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=1

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample11 5  1 1  21   11 9
# mutation11 4  1 1  21   11 9
nonsynonymous SNV 1 3  1 1  21    1 8
synonymous SNV1  1            1  1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr8:103845440p.H250Y,AZIN12
chr8:103842067p.E303G,AZIN11
chr8:103851101p.E165K,AZIN11
chr8:103842099p.D159G,AZIN11
chr8:103851945p.L139L,AZIN11
chr8:103842132p.I137M,AZIN11
chr8:103851961p.Q116R,AZIN11
chr8:103842139p.N107S,AZIN11
chr8:103852020p.C70Y,AZIN11
chr8:103842161p.D397N,AZIN11

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for AZIN1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AZIN1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ARFGEF1,ARMC1,ATP6V1C1,AZIN1,CPNE3,DCAF13,DERL1,
DPY19L4,ESRP1,FAM91A1,KIAA0196,MTDH,OTUD6B,RRM2B,
SLC25A32,STK3,EMC2,UBE2W,UBR5,YWHAZ,ZNF252P
ARIH1,AZIN1,COG5,COPB1,CPNE3,DHX29,DIS3,
KIAA0196,MBTPS2,MTDH,NBN,NMD3,PPP2R5E,SKIV2L2,
SLC25A24,SMAD2,TM9SF3,UBE2W,UBQLN1,YTHDF3,ZFR

ANKRD46,ARMC1,ATP6V1C1,AZIN1,COPS5,CPNE3,DCAF13,
FAM91A1,MED30,MTFR1,NSMCE2,NUDCD1,OTUD6B,POLR2K,
RAD21,SLC25A32,TAF2,TATDN1,UBE2W,UTP23,ZFAND1
AIG1,ASAH2,AZIN1,SUCO,CRHR1,CRYZ,CYB5A,
DDX1,FAM3C,GALK1,GCHFR,HACL1,MPP6,PAQR3,
PIK3C2G,RNF141,SLC25A15,SLC2A12,SMURF2,TMEM41A,VNN1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AZIN1


There's no related Drug.
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Cross referenced IDs for AZIN1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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