Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for GNG13
Basic gene info.Gene symbolGNG13
Gene nameguanine nucleotide binding protein (G protein), gamma 13
SynonymsG(gamma)13|h2-35
CytomapUCSC genome browser: 16p13.3
Genomic locationchr16 :848040-850733
Type of geneprotein-coding
RefGenesNM_016541.2,
Ensembl idENSG00000127588
DescriptionG gamma subunit, clone:h2-35guanine nucleotide binding protein 13, gammaguanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Modification date20141207
dbXrefs MIM : 607298
HGNC : HGNC
Ensembl : ENSG00000127588
HPRD : 12116
Vega : OTTHUMG00000047839
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GNG13
BioGPS: 51764
Gene Expression Atlas: ENSG00000127588
The Human Protein Atlas: ENSG00000127588
PathwayNCI Pathway Interaction Database: GNG13
KEGG: GNG13
REACTOME: GNG13
ConsensusPathDB
Pathway Commons: GNG13
MetabolismMetaCyc: GNG13
HUMANCyc: GNG13
RegulationEnsembl's Regulation: ENSG00000127588
miRBase: chr16 :848,040-850,733
TargetScan: NM_016541
cisRED: ENSG00000127588
ContextiHOP: GNG13
cancer metabolism search in PubMed: GNG13
UCL Cancer Institute: GNG13
Assigned class in ccmGDBC

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Phenotypic Information for GNG13(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: GNG13
Familial Cancer Database: GNG13
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: GNG13
MedGen: GNG13 (Human Medical Genetics with Condition)
ClinVar: GNG13
PhenotypeMGI: GNG13 (International Mouse Phenotyping Consortium)
PhenomicDB: GNG13

Mutations for GNG13
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows GNG13 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=3)
Stat. for Synonymous SNVs
(# total SNVs=5)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr16:848773-848773p.P50P2
chr16:849007-849007p.R24Q2
chr16:849069-849071p.E3delE1
chr16:848741-848741p.K61R1
chr16:848746-848746p.V59V1
chr16:848755-848755p.N56N1
chr16:848769-848769p.L52L1
chr16:848772-848772p.D51N1
chr16:849011-849012p.F22_Q23>LK1
chr16:849032-849033p.S15_L16>RI1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample             1   2 3
# mutation             1   1 3
nonsynonymous SNV             1   1 1
synonymous SNV                   2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr16:849007p.R24L2
chr16:848769p.L52L1
chr16:848772p.D51N1
chr16:848773p.P50P1
chr16:849054p.Q8H1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for GNG13 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for GNG13

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

CALCR,DKFZp686A1627,GHITM,GNG13,HAGHL,LOC219347,METRN,
MSLNL,MYH7B,LINC00176,POLR3K,RBMY1A1,RBMY1A3P,RBMY1E,
RBMY1F,RBMY1J,RBMY2FP,RBMY3AP,SSTR1,TSPY1,TSPY2
BEX1,LINC00238,PRR35,CHRNA9,COL2A1,CST9,DEFB4A,
FAM135B,FAM196A,FCRLB,GLDC,GNG13,KISS1R,NELL1,
PTPN1,RIMS4,SLIT1,TCL1B,TTLL8,WFDC11,ZDHHC22

ACSM3,AVIL,BMX,C12orf77,CALHM1,GNG13,GRIK1,
HTR3C,HTR3E,IL25,OR2T34,PRH1,PRH2,RGS13,
RGS21,SH2D6,SH2D7,TAS1R1,TAS1R2,TCL6,USP26
ALOX12B,AVIL,B4GALNT4,BMX,CCDC129,EPB41,GNG13,
HMX3,HTR3C,HTR3E,KLK13,KLK14,LINC01512,LPA,
PLEKHG7,POU2F3,SH2D6,SH2D7,TAS1R3,TRPM5,VGLL4
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for GNG13


There's no related Drug.
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Cross referenced IDs for GNG13
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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