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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ACP1 |
Basic gene info. | Gene symbol | ACP1 |
Gene name | acid phosphatase 1, soluble | |
Synonyms | HAAP | |
Cytomap | UCSC genome browser: 2p25 | |
Genomic location | chr2 :264868-278282 | |
Type of gene | protein-coding | |
RefGenes | NM_001040649.2, NM_004300.3,NM_007099.3,NR_024080.1,NM_177554.1, | |
Ensembl id | ENSG00000143727 | |
Description | LMW-PTPLMW-PTPaseacid phosphatase of erythrocyteadipocyte acid phosphatasecytoplasmic phosphotyrosyl protein phosphataselow molecular weight cytosolic acid phosphataselow molecular weight phosphotyrosine protein phosphataseprotein tyrosine phosphat | |
Modification date | 20141207 | |
dbXrefs | MIM : 171500 | |
HGNC : HGNC | ||
Ensembl : ENSG00000143727 | ||
HPRD : 08881 | ||
Vega : OTTHUMG00000086933 | ||
Protein | UniProt: P24666 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACP1 | |
BioGPS: 52 | ||
Gene Expression Atlas: ENSG00000143727 | ||
The Human Protein Atlas: ENSG00000143727 | ||
Pathway | NCI Pathway Interaction Database: ACP1 | |
KEGG: ACP1 | ||
REACTOME: ACP1 | ||
ConsensusPathDB | ||
Pathway Commons: ACP1 | ||
Metabolism | MetaCyc: ACP1 | |
HUMANCyc: ACP1 | ||
Regulation | Ensembl's Regulation: ENSG00000143727 | |
miRBase: chr2 :264,868-278,282 | ||
TargetScan: NM_001040649 | ||
cisRED: ENSG00000143727 | ||
Context | iHOP: ACP1 | |
cancer metabolism search in PubMed: ACP1 | ||
UCL Cancer Institute: ACP1 | ||
Assigned class in ccmGDB | A - This gene has a literature evidence and it belongs to cancer gene. | |
References showing role of ACP1 in cancer cell metabolism | 1. Pedersen K, Canals F, Prat A, Tabernero J, Arribas J (2014) PELO negatively regulates HER receptor signalling and metastasis. Oncogene 33: 1190-1197. doi: 10.1038/onc.2013.35. go to article 2. Wright WC, Daniels WP, Fogh J (1981) Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis. J Natl Cancer Inst 66: 239-247. go to article |
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Phenotypic Information for ACP1(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: ACP1 |
Familial Cancer Database: ACP1 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_RIBOFLAVIN_METABOLISM |
Others | |
OMIM | 171500; gene. 171500; gene. |
Orphanet | |
Disease | KEGG Disease: ACP1 |
MedGen: ACP1 (Human Medical Genetics with Condition) | |
ClinVar: ACP1 | |
Phenotype | MGI: ACP1 (International Mouse Phenotyping Consortium) |
PhenomicDB: ACP1 |
Mutations for ACP1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ACP1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=19) | (# total SNVs=7) |
(# total SNVs=1) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr2:272081-272081 | p.P56fs*9 | 2 |
chr2:277079-277079 | p.P131P | 2 |
chr2:272128-272128 | p.P70L | 2 |
chr2:277002-277002 | p.Q106* | 2 |
chr2:277291-277291 | p.E155V | 2 |
chr2:277034-277034 | p.L116L | 2 |
chr2:272060-272060 | p.T47T | 1 |
chr2:277042-277042 | p.S119N | 1 |
chr2:265004-265004 | p.L14V | 1 |
chr2:272065-272065 | p.G49V | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 |   |   | 1 |   |   | 1 |   | 1 |   |   | 3 | 2 | 1 |   |   | 3 | 1 |   | 5 |
# mutation | 1 |   |   | 3 |   |   | 1 |   | 1 |   |   | 4 | 3 | 1 |   |   | 3 | 1 |   | 5 |
nonsynonymous SNV |   |   |   | 2 |   |   | 1 |   | 1 |   |   | 1 | 3 | 1 |   |   | 2 |   |   | 5 |
synonymous SNV | 1 |   |   | 1 |   |   |   |   |   |   |   | 3 |   |   |   |   | 1 | 1 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr2:277250 | p.T141T,ACP1 | 2 |
chr2:272236 | p.G106V | 2 |
chr2:272289 | p.A112P,ACP1 | 1 |
chr2:271878 | p.S119N,ACP1 | 1 |
chr2:275176 | p.P122S,ACP1 | 1 |
chr2:271881 | p.L14V,ACP1 | 1 |
chr2:277020 | p.D130E,ACP1 | 1 |
chr2:271918 | p.C18C,ACP1 | 1 |
chr2:277042 | p.P131P,ACP1 | 1 |
chr2:272047 | p.R19Q,ACP1 | 1 |
Other DBs for Point Mutations |
Copy Number for ACP1 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ACP1 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ACP1,BOLA3,COX7A2L,CPSF3,DPY30,E2F6,FAM136A, IAH1,MDH1,MEMO1,NOL10,PNO1,RNASEH1,RPS7, SF3B14,SH3YL1,SNRPG,TMEM18,TSSC1,USP39,YWHAQ | ACP1,ATXN10,CCNB1IP1,DENR,DUS4L,EIF3E,ENOPH1, FAM103A1,FARSB,GTF2F2,NIFK,MRPL3,MRPS35,OLA1, PPA2,RPL15,RSL24D1,TMEM5,TMEM69,TOMM20,TTC19 | ||||
ACP1,CCT4,CCT7,CPSF3,DPY30,FAM136A,GPN1, MEMO1,METTL5,NIFK,MRPL30,OLA1,PNO1,PTCD3, RPS7,SF3B14,SNRPG,SUMO1,TPRKB,USP39,YWHAQ | ACP1,ALG5,ATG3,CCNC,CNIH1,EBAG9,EEF1B2, FAM96A,MAGT1,MRPL48,MRPS22,PDCD2,POC1B,PPA2, PSMD10,RCHY1,SEP15,SRP9,TGDS,TXNDC12,UQCRH |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for ACP1 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Chemistry | BindingDB | P24666; -. |
Chemistry | ChEMBL | CHEMBL4903; -. |
Chemistry | BindingDB | P24666; -. |
Chemistry | ChEMBL | CHEMBL4903; -. |
Organism-specific databases | PharmGKB | PA24446; -. |
Organism-specific databases | PharmGKB | PA24446; -. |
Organism-specific databases | CTD | 52; -. |
Organism-specific databases | CTD | 52; -. |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00173 | acid phosphatase 1, soluble | approved; nutraceutical | Adenine | ||
DB04214 | acid phosphatase 1, soluble | experimental | 4-Nitrophenyl Phosphate |
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Cross referenced IDs for ACP1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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