Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for PFKFB2
Basic gene info.Gene symbolPFKFB2
Gene name6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
SynonymsPFK-2/FBPase-2
CytomapUCSC genome browser: 1q31
Genomic locationchr1 :207226619-207254368
Type of geneprotein-coding
RefGenesNM_001018053.1,
NM_006212.2,
Ensembl idENSG00000123836
Description6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 26PF-2-K/Fru-2,6-P2ASE heart-type isozyme6PF-2-K/Fru-2,6-P2ase 2PFK/FBPase 2PFKFB, cardiacfructose-2,6-bisphosphatase, cardiac isozyme
Modification date20141207
dbXrefs MIM : 171835
HGNC : HGNC
Ensembl : ENSG00000123836
HPRD : 01383
Vega : OTTHUMG00000036033
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PFKFB2
BioGPS: 5208
Gene Expression Atlas: ENSG00000123836
The Human Protein Atlas: ENSG00000123836
PathwayNCI Pathway Interaction Database: PFKFB2
KEGG: PFKFB2
REACTOME: PFKFB2
ConsensusPathDB
Pathway Commons: PFKFB2
MetabolismMetaCyc: PFKFB2
HUMANCyc: PFKFB2
RegulationEnsembl's Regulation: ENSG00000123836
miRBase: chr1 :207,226,619-207,254,368
TargetScan: NM_001018053
cisRED: ENSG00000123836
ContextiHOP: PFKFB2
cancer metabolism search in PubMed: PFKFB2
UCL Cancer Institute: PFKFB2
Assigned class in ccmGDBC

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Phenotypic Information for PFKFB2(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: PFKFB2
Familial Cancer Database: PFKFB2
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM
REACTOME_METABOLISM_OF_CARBOHYDRATES
REACTOME_GLUCOSE_METABOLISM

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: PFKFB2
MedGen: PFKFB2 (Human Medical Genetics with Condition)
ClinVar: PFKFB2
PhenotypeMGI: PFKFB2 (International Mouse Phenotyping Consortium)
PhenomicDB: PFKFB2

Mutations for PFKFB2
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PFKFB2 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AF063569APOA2202741161192082161192731PFKFB22676041207221981207222316
AI110694APOA2202741161192082161192731PFKFB22676041207221981207222316
AF090896APOA2202741161192082161192731PFKFB226729071207219676207222316
W27604PFKFB2192171207236026207236753PFKFB22114241207242791207243754
BE173373PFKFB2142991207250792207251120DDHD1290687145350968553510086

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample2                
GAIN (# sample)2                
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=26)
Stat. for Synonymous SNVs
(# total SNVs=24)
Stat. for Deletions
(# total SNVs=3)
Stat. for Insertions
(# total SNVs=1)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr1:207242789-207242789p.T336T4
chr1:207245617-207245617p.S473S3
chr1:207228072-207228072p.A4T2
chr1:207235357-207235357p.R49W1
chr1:207241610-207241610p.G315W1
chr1:207242844-207242844p.K355E1
chr1:207236506-207236506p.A109A1
chr1:207245616-207245616p.S473L1
chr1:207238492-207238492p.D207N1
chr1:207235390-207235390p.R60C1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample21 8  4 2  211  74 9
# mutation21 8  4 2  511  74 9
nonsynonymous SNV1  5  4 1  311  64 4
synonymous SNV11 4    1  2    1  5
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr1:207242833p.R351Q,PFKFB22
chr1:207236057p.S156S,PFKFB22
chr1:207240955p.S473S2
chr1:207245617p.Q248Q,PFKFB22
chr1:207237135p.R102S,PFKFB22
chr1:207235985p.L117L,PFKFB21
chr1:207245637p.C332C,PFKFB21
chr1:207240856p.I124T,PFKFB21
chr1:207242814p.P345A,PFKFB21
chr1:207235990p.F143F,PFKFB21

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for PFKFB2 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for PFKFB2

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ANGPTL5,C10orf90,CAPN11,CD2AP,CDC5L,CYP39A1,ENPP4,
GPR111,NMRK2,LOC221442,LOC285501,LRRTM1,MOG,MRPS10,
MUT,PFKFB2,PRUNE2,SLC29A1,SLC6A17,SYT14,UBR2
ALCAM,ATP13A4,CEP128,CCDC57,CROT,DOPEY2,EML5,
ESRRG,HMGCR,ITPR3,KIAA1244,LOC646471,MBOAT2,MOGAT2,
NSUN2,PFKFB2,PXMP4,SLC38A1,STYK1,TMEM63C,ZCCHC6

ARHGEF11,RUSC1-AS1,CC2D1A,CES3,ENTPD5,GOLPH3L,KIAA1804,
PFKFB2,PIK3C2B,PLEKHA6,PPARA,PPARGC1B,PPP1R15B,SEC16B,
SGK2,SLC25A44,SULT1B1,TAF5L,TARS2,VPS45,ZNF774
ABCC3,AFG3L2,ARFGEF2,ATP7B,ATP8A1,DNAJC16,ENTPD5,
FRYL,GUF1,KDM7A,MED14,NBEAL1,PFKFB2,PLCE1,
PLEKHH1,PRSS12,SAMD12,TET3,TMEM131,ZDHHC23,ZNF808
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for PFKFB2


There's no related Drug.
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Cross referenced IDs for PFKFB2
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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