Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for ABCB1

Basic gene info.	Gene symbol	ABCB1
	Gene name	ATP-binding cassette, sub-family B (MDR/TAP), member 1
	Synonyms	ABC20\|CD243\|CLCS\|GP170\|MDR1\|P-GP\|PGY1
	Cytomap	UCSC genome browser: 7q21.12
	Genomic location	chr7 :87133178-87342639
	Type of gene	protein-coding
	RefGenes	NM_000927.4,
	Ensembl id	ENSG00000085563
	Description	P-glycoprotein 1colchicin sensitivitydoxorubicin resistancemultidrug resistance protein 1
	Modification date	20141222
dbXrefs	MIM : 171050
	HGNC : HGNC
	Ensembl : ENSG00000085563
	HPRD : 01370
	Vega : OTTHUMG00000023393
Protein	UniProt: P08183 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ABCB1
	BioGPS: 5243
	Gene Expression Atlas: ENSG00000085563
	The Human Protein Atlas: ENSG00000085563
Pathway	NCI Pathway Interaction Database: ABCB1
	KEGG: ABCB1
	REACTOME: ABCB1
	ConsensusPathDB
	Pathway Commons: ABCB1
Metabolism	MetaCyc: ABCB1
	HUMANCyc: ABCB1
Regulation	Ensembl's Regulation: ENSG00000085563
	miRBase: chr7 :87,133,178-87,342,639
	TargetScan: NM_000927
	cisRED: ENSG00000085563
Context	iHOP: ABCB1
	cancer metabolism search in PubMed: ABCB1
	UCL Cancer Institute: ABCB1
Assigned class in ccmGDB	A - This gene has a literature evidence and it belongs to cancer gene.
References showing role of ABCB1 in cancer cell metabolism	1. Staubert C, Bhuiyan H, Lindahl A, Broom OJ, Zhu Y, et al. (2015) Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine. J Biol Chem 290: 8348-8359. doi: 10.1074/jbc.M114.618769. pmid: 4375488 go to article 2. Celestino AT, Levy D, Maria Ruiz JL, Bydlowski SP (2015) ABCB1, ABCC1, and LRP gene expressions are altered by LDL, HDL, and serum deprivation in a human doxorubicin-resistant uterine sarcoma cell line. Biochem Biophys Res Commun 457: 664-668. doi: 10.1016/j.bbrc.2015.01.045. go to article

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Phenotypic Information for ABCB1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: ABCB1
	Familial Cancer Database: ABCB1

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in GBM ⁶,	Therapeutic Vulnerabilities in Cancer⁷

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
6 http://www.sciencedirect.com/science/article/pii/S0092867413012087,
7Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM

Others
OMIM	171050; gene. 612244; phenotype.
Orphanet	771; Ulcerative colitis.
Disease	KEGG Disease: ABCB1
	MedGen: ABCB1 (Human Medical Genetics with Condition)
	ClinVar: ABCB1
Phenotype	MGI: ABCB1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: ABCB1

Mutations for ABCB1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
ovary	ABCB1	chr7	87133165	87133185	ABCB1	chr7	87134694	87134714
ovary	ABCB1	chr7	87138847	87138867	ABCB1	chr7	87138904	87138924
ovary	ABCB1	chr7	87238833	87238853	SLC25A40	chr7	87502276	87502296
ovary	ABCB1	chr7	87246189	87246209	SLC25A40	chr7	87501861	87501881
ovary	ABCB1	chr7	87248280	87248300	PRAF2	chr23	48929133	48929153

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ABCB1 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

AF345337

GRM3

204

86331484

86331687

ABCB1

203

274

87230325

87230396

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=7

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=232)	Stat. for Synonymous SNVs (# total SNVs=43)

Stat. for Deletions (# total SNVs=6)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr7:87179322-87179322	p.R467W	7
chr7:87179871-87179871	p.S379S	5
chr7:87179797-87179797	p.R404Q	4
chr7:87214993-87214993	p.R41C	4
chr7:87183219-87183219	p.R286I	4
chr7:87175237-87175237	p.G610E	4
chr7:87144635-87144635	p.T1065M	4
chr7:87179256-87179256	p.R489C	4
chr7:87190589-87190589	p.E273*	4
chr7:87170746-87170746	p.R749Q	3

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=6

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	3	10		28	10		12		6	1		34	14	5	2	2	38	17		26
# mutation	5	10		33	10		12		7	1		37	17	5	2	2	44	20		37
nonsynonymous SNV	5	4		28	10		10		7	1		29	16	4		2	33	15		28
synonymous SNV		6		5			2					8	1	1	2		11	5		9

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr7:87148696	p.R958Q	3
chr7:87179322	p.G610E	3
chr7:87175237	p.R41H	3
chr7:87214992	p.R467W	3
chr7:87214993	p.R41C	3
chr7:87179256	p.R489C	3
chr7:87148649	p.A718D	2
chr7:87160636	p.E468K	2
chr7:87173569	p.R467L	2
chr7:87150160	p.G390A	2

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for ABCB1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ABCB1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ABCB11,ADCY1,BCO2,ERICH3,C7,DEFB130,DHRS9, GRB14,GSTA2,KIAA1377,LRP2,LRP4,NDST4,NPAS3, NR5A1,PEX5L,PMCHL1,PMCHL2,SGCG,UBXN10,VRK2	ABCB11,ADH1A,ADH1B,ANKRD53,C6,CALCRL,CIDEA, CNTFR,DNAH9,GHR,GLUL,HRSP12,IRAK2,NWD2, LOC100190938,MOCS1,RGS17,RORB,SLC19A3,TM7SF2,AGMO

ABCB11,BTNL3,C11orf86,LINC00520,CA2,CEACAM7,CLCA4, DHRS9,EDN3,EMP1,GDPD2,GDPD3,GUCA2B,MMP28, MXD1,MYPN,OTOP2,PLAC8,SLC17A4,TMIGD1,TSPAN1	ABCB11,ANK3,AQP8,ARL15,LINC00597,CYP2B7P,EPB41L5, FLNB,GLB1L2,HSPB3,LOC25845,ME3,PDE8A,PGAP3, RUNDC1,SLC20A1,SLC45A2,SLC9A3,TAT,UNC5B,ZNF575

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ABCB1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category	DB Name	DB's ID and Url link
Chemistry	BindingDB	P08183; -.
Chemistry	ChEMBL	CHEMBL4302; -.
Organism-specific databases	PharmGKB	PA267; -.
Organism-specific databases	CTD	5243; -.

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00171	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; nutraceutical	Adenosine triphosphate
DB00778	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Roxithromycin
DB04877	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Voacamine
DB00694	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Daunorubicin
DB00997	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Doxorubicin
DB01229	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Paclitaxel
DB00485	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Dicloxacillin
DB00932	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Tipranavir
DB00201	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Caffeine
DB00514	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Dextromethorphan
DB00762	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Irinotecan
DB00198	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Oseltamivir
DB00709	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Lamivudine
DB00526	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Oxaliplatin
DB01042	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Melphalan
DB00571	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Propranolol
DB00143	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; nutraceutical	Glutathione
DB00381	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Amlodipine
DB00497	ATP-binding cassette, sub-family B (MDR/TAP), member 1	illicit; approved; investigational	Oxycodone
DB00308	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Ibutilide
DB00318	ATP-binding cassette, sub-family B (MDR/TAP), member 1	illicit; approved	Codeine
DB00215	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Citalopram
DB00207	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Azithromycin
DB01258	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Aliskiren
DB00736	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Esomeprazole
DB00338	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Omeprazole
DB00213	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Pantoprazole
DB00158	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; nutraceutical	Folic Acid
DB00495	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Zidovudine
DB00819	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Acetazolamide
DB00829	ATP-binding cassette, sub-family B (MDR/TAP), member 1	illicit; approved	Diazepam
DB00593	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Ethosuximide
DB00754	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Ethotoin
DB01595	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Nitrazepam
DB00909	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Zonisamide
DB00349	ATP-binding cassette, sub-family B (MDR/TAP), member 1	illicit; approved; investigational	Clobazam
DB01068	ATP-binding cassette, sub-family B (MDR/TAP), member 1	illicit; approved	Clonazepam
DB00273	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Topiramate
DB01080	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Vigabatrin
DB01177	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Idarubicin
DB01175	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Escitalopram
DB01248	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Docetaxel
DB04630	ATP-binding cassette, sub-family B (MDR/TAP), member 1	experimental	Aldosterone
DB00523	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Alitretinoin
DB01118	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Amiodarone
DB00321	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Amitriptyline
DB00701	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Amprenavir
DB00637	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; withdrawn	Astemizole
DB01244	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Bepridil
DB01200	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Bromocriptine
DB01136	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Carvedilol
DB00291	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Chlorambucil
DB00477	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Chlorpromazine
DB00501	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Cimetidine
DB00515	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Cisplatin
DB01211	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Clarithromycin
DB00257	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Clotrimazole
DB00970	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Dactinomycin
DB00975	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Dipyridamole
DB00822	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Disulfiram
DB01184	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Domperidone
DB00254	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Doxycycline
DB01023	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Felodipine
DB00741	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Hydrocortisone
DB01005	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Hydroxyurea
DB00224	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Indinavir
DB00602	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Ivermectin
DB01137	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Levofloxacin
DB00836	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Loperamide
DB00678	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Losartan
DB00959	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Methylprednisolone
DB00305	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Mitomycin
DB01204	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Mitoxantrone
DB00622	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Nicardipine
DB01115	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Nifedipine
DB01054	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Nitrendipine
DB00904	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Ondansetron
DB00715	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Paroxetine
DB00652	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Pentazocine
DB01032	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Probenecid
DB00396	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Progesterone
DB00420	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Promazine
DB01182	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Propafenone
DB00908	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Quinidine
DB00468	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Quinine
DB00863	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Ranitidine
DB00206	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Reserpine
DB01104	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Sertraline
DB01208	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Sparfloxacin
DB00675	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Tamoxifen
DB00444	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Teniposide
DB00342	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; withdrawn	Terfenadine
DB04844	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Tetrabenazine
DB00759	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Tetracycline
DB01030	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Topotecan
DB00755	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; nutraceutical; investigational	Tretinoin
DB01339	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Vecuronium
DB01392	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Yohimbine
DB00363	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Clozapine
DB00445	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Epirubicin
DB00285	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Venlafaxine
DB00683	ATP-binding cassette, sub-family B (MDR/TAP), member 1	illicit; approved	Midazolam
DB00317	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Gefitinib
DB00993	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Azathioprine
DB00661	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Verapamil
DB00570	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Vinblastine
DB00530	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Erlotinib
DB01026	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Ketoconazole
DB00540	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Nortriptyline
DB00333	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Methadone
DB01452	ATP-binding cassette, sub-family B (MDR/TAP), member 1	illicit; experimental	Heroin
DB01076	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Atorvastatin
DB00439	ATP-binding cassette, sub-family B (MDR/TAP), member 1	withdrawn	Cerivastatin
DB00343	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Diltiazem
DB01095	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Fluvastatin
DB01241	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Gemfibrozil
DB01167	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Itraconazole
DB00227	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Lovastatin
DB00175	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Pravastatin
DB00503	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Ritonavir
DB01098	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Rosuvastatin
DB00996	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Gabapentin
DB00555	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Lamotrigine
DB01202	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Levetiracetam
DB01174	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Phenobarbital
DB00472	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Fluoxetine
DB00252	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Phenytoin
DB00877	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Sirolimus
DB01169	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Arsenic trioxide
DB00950	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Fexofenadine
DB00316	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Acetaminophen
DB00295	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Morphine
DB00813	ATP-binding cassette, sub-family B (MDR/TAP), member 1	illicit; approved; investigational	Fentanyl
DB00624	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Testosterone
DB00352	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Thioguanine
DB00196	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Fluconazole
DB00958	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Carboplatin
DB00199	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Erythromycin
DB00448	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Lansoprazole
DB01222	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Budesonide
DB00641	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Simvastatin
DB00889	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Granisetron
DB00619	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Imatinib
DB00564	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Carbamazepine
DB00987	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Cytarabine
DB01234	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Dexamethasone
DB00773	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Etoposide
DB00650	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Leucovorin
DB01033	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Mercaptopurine
DB00563	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Methotrexate
DB00635	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Prednisone
DB00541	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Vincristine
DB00973	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Ezetimibe
DB01045	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Rifampin
DB00758	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; nutraceutical	Clopidogrel
DB00864	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Tacrolimus
DB00358	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Mefloquine
DB01072	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Atazanavir
DB01601	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Lopinavir
DB01232	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Saquinavir
DB00531	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Cyclophosphamide
DB00734	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Risperidone
DB00625	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Efavirenz
DB00441	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Gemcitabine
DB00220	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Nelfinavir
DB00238	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Nevirapine
DB00313	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Valproic Acid
DB00390	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Digoxin
DB01394	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Colchicine
DB00544	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Fluorouracil
DB00682	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Warfarin
DB00334	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Olanzapine
DB01016	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Glyburide
DB00412	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Rosiglitazone
DB00331	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Metformin
DB00688	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Mycophenolate mofetil
DB02587	ATP-binding cassette, sub-family B (MDR/TAP), member 1	experimental	Forskolin
DB00457	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Prazosin
DB01048	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved; investigational	Abacavir
DB00451	ATP-binding cassette, sub-family B (MDR/TAP), member 1	approved	Levothyroxine

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Cross referenced IDs for ABCB1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information