Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for ABCB1
Basic gene info.Gene symbolABCB1
Gene nameATP-binding cassette, sub-family B (MDR/TAP), member 1
SynonymsABC20|CD243|CLCS|GP170|MDR1|P-GP|PGY1
CytomapUCSC genome browser: 7q21.12
Genomic locationchr7 :87133178-87342639
Type of geneprotein-coding
RefGenesNM_000927.4,
Ensembl idENSG00000085563
DescriptionP-glycoprotein 1colchicin sensitivitydoxorubicin resistancemultidrug resistance protein 1
Modification date20141222
dbXrefs MIM : 171050
HGNC : HGNC
Ensembl : ENSG00000085563
HPRD : 01370
Vega : OTTHUMG00000023393
ProteinUniProt: P08183
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ABCB1
BioGPS: 5243
Gene Expression Atlas: ENSG00000085563
The Human Protein Atlas: ENSG00000085563
PathwayNCI Pathway Interaction Database: ABCB1
KEGG: ABCB1
REACTOME: ABCB1
ConsensusPathDB
Pathway Commons: ABCB1
MetabolismMetaCyc: ABCB1
HUMANCyc: ABCB1
RegulationEnsembl's Regulation: ENSG00000085563
miRBase: chr7 :87,133,178-87,342,639
TargetScan: NM_000927
cisRED: ENSG00000085563
ContextiHOP: ABCB1
cancer metabolism search in PubMed: ABCB1
UCL Cancer Institute: ABCB1
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of ABCB1 in cancer cell metabolism1. Staubert C, Bhuiyan H, Lindahl A, Broom OJ, Zhu Y, et al. (2015) Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine. J Biol Chem 290: 8348-8359. doi: 10.1074/jbc.M114.618769. pmid: 4375488 go to article
2. Celestino AT, Levy D, Maria Ruiz JL, Bydlowski SP (2015) ABCB1, ABCC1, and LRP gene expressions are altered by LDL, HDL, and serum deprivation in a human doxorubicin-resistant uterine sarcoma cell line. Biochem Biophys Res Commun 457: 664-668. doi: 10.1016/j.bbrc.2015.01.045. go to article

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Phenotypic Information for ABCB1(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: ABCB1
Familial Cancer Database: ABCB1
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in GBM 6,

Therapeutic Vulnerabilities in Cancer7

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
6 http://www.sciencedirect.com/science/article/pii/S0092867413012087,
7Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM

check002.gifOthers
OMIM 171050; gene.
612244; phenotype.
Orphanet 771; Ulcerative colitis.
DiseaseKEGG Disease: ABCB1
MedGen: ABCB1 (Human Medical Genetics with Condition)
ClinVar: ABCB1
PhenotypeMGI: ABCB1 (International Mouse Phenotyping Consortium)
PhenomicDB: ABCB1

Mutations for ABCB1
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
ovaryABCB1chr78713316587133185ABCB1chr78713469487134714
ovaryABCB1chr78713884787138867ABCB1chr78713890487138924
ovaryABCB1chr78723883387238853SLC25A40chr78750227687502296
ovaryABCB1chr78724618987246209SLC25A40chr78750186187501881
ovaryABCB1chr78724828087248300PRAF2chr234892913348929153
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ABCB1 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a
AF345337GRM3120478633148486331687ABCB120327478723032587230396

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample 11   1 2     4  
GAIN (# sample) 11   1 2     4  
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=7

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=232)
Stat. for Synonymous SNVs
(# total SNVs=43)
Stat. for Deletions
(# total SNVs=6)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr7:87179322-87179322p.R467W7
chr7:87179871-87179871p.S379S5
chr7:87175237-87175237p.G610E4
chr7:87144635-87144635p.T1065M4
chr7:87179256-87179256p.R489C4
chr7:87190589-87190589p.E273*4
chr7:87179797-87179797p.R404Q4
chr7:87214993-87214993p.R41C4
chr7:87183219-87183219p.R286I4
chr7:87165842-87165842p.D805N3

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=6

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample310 2810 12 61 34145223817 26
# mutation510 3310 12 71 37175224420 37
nonsynonymous SNV54 2810 10 71 29164 23315 28
synonymous SNV 6 5  2    8112 115 9
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr7:87148696p.R958Q3
chr7:87175237p.G610E3
chr7:87179322p.R467W3
chr7:87214992p.R41H3
chr7:87214993p.R41C3
chr7:87179256p.R489C3
chr7:87179321p.R467L2
chr7:87214866p.G390A2
chr7:87180059p.S696F2
chr7:87170679p.K887E2

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for ABCB1 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for ABCB1

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ABCB11,ADCY1,BCO2,ERICH3,C7,DEFB130,DHRS9,
GRB14,GSTA2,KIAA1377,LRP2,LRP4,NDST4,NPAS3,
NR5A1,PEX5L,PMCHL1,PMCHL2,SGCG,UBXN10,VRK2
ABCB11,ADH1A,ADH1B,ANKRD53,C6,CALCRL,CIDEA,
CNTFR,DNAH9,GHR,GLUL,HRSP12,IRAK2,NWD2,
LOC100190938,MOCS1,RGS17,RORB,SLC19A3,TM7SF2,AGMO

ABCB11,BTNL3,C11orf86,LINC00520,CA2,CEACAM7,CLCA4,
DHRS9,EDN3,EMP1,GDPD2,GDPD3,GUCA2B,MMP28,
MXD1,MYPN,OTOP2,PLAC8,SLC17A4,TMIGD1,TSPAN1
ABCB11,ANK3,AQP8,ARL15,LINC00597,CYP2B7P,EPB41L5,
FLNB,GLB1L2,HSPB3,LOC25845,ME3,PDE8A,PGAP3,
RUNDC1,SLC20A1,SLC45A2,SLC9A3,TAT,UNC5B,ZNF575
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for ABCB1
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB P08183; -.
ChemistryChEMBL CHEMBL4302; -.
Organism-specific databasesPharmGKB PA267; -.
Organism-specific databasesCTD 5243; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00171ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; nutraceuticalAdenosine triphosphate
DB00778ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedRoxithromycin
DB04877ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalVoacamine
DB00694ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedDaunorubicin
DB00997ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalDoxorubicin
DB01229ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPaclitaxel
DB00485ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedDicloxacillin
DB00932ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalTipranavir
DB00201ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedCaffeine
DB00514ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedDextromethorphan
DB00762ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalIrinotecan
DB00198ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedOseltamivir
DB00709ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalLamivudine
DB00526ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalOxaliplatin
DB01042ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedMelphalan
DB00571ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalPropranolol
DB00143ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; nutraceuticalGlutathione
DB00381ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedAmlodipine
DB00497ATP-binding cassette, sub-family B (MDR/TAP), member 1illicit; approved; investigationalOxycodone
DB00308ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedIbutilide
DB00318ATP-binding cassette, sub-family B (MDR/TAP), member 1illicit; approvedCodeine
DB00215ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedCitalopram
DB00207ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedAzithromycin
DB01258ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalAliskiren
DB00736ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalEsomeprazole
DB00338ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalOmeprazole
DB00213ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPantoprazole
DB00158ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; nutraceuticalFolic Acid
DB00495ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedZidovudine
DB00819ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedAcetazolamide
DB00829ATP-binding cassette, sub-family B (MDR/TAP), member 1illicit; approvedDiazepam
DB00593ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedEthosuximide
DB00754ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedEthotoin
DB01595ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedNitrazepam
DB00909ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalZonisamide
DB00349ATP-binding cassette, sub-family B (MDR/TAP), member 1illicit; approved; investigationalClobazam
DB01068ATP-binding cassette, sub-family B (MDR/TAP), member 1illicit; approvedClonazepam
DB00273ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalTopiramate
DB01080ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedVigabatrin
DB01177ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedIdarubicin
DB01175ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalEscitalopram
DB01248ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalDocetaxel
DB04630ATP-binding cassette, sub-family B (MDR/TAP), member 1experimentalAldosterone
DB00523ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalAlitretinoin
DB01118ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalAmiodarone
DB00321ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedAmitriptyline
DB00701ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedAmprenavir
DB00637ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; withdrawnAstemizole
DB01244ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedBepridil
DB01200ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalBromocriptine
DB01136ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalCarvedilol
DB00291ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedChlorambucil
DB00477ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedChlorpromazine
DB00501ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedCimetidine
DB00515ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedCisplatin
DB01211ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedClarithromycin
DB00257ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedClotrimazole
DB00970ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedDactinomycin
DB00975ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedDipyridamole
DB00822ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedDisulfiram
DB01184ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedDomperidone
DB00254ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalDoxycycline
DB01023ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalFelodipine
DB00741ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedHydrocortisone
DB01005ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedHydroxyurea
DB00224ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedIndinavir
DB00602ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedIvermectin
DB01137ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalLevofloxacin
DB00836ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedLoperamide
DB00678ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedLosartan
DB00959ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedMethylprednisolone
DB00305ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedMitomycin
DB01204ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalMitoxantrone
DB00622ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedNicardipine
DB01115ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedNifedipine
DB01054ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedNitrendipine
DB00904ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedOndansetron
DB00715ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalParoxetine
DB00652ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPentazocine
DB01032ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedProbenecid
DB00396ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedProgesterone
DB00420ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPromazine
DB01182ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPropafenone
DB00908ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedQuinidine
DB00468ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedQuinine
DB00863ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedRanitidine
DB00206ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedReserpine
DB01104ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedSertraline
DB01208ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedSparfloxacin
DB00675ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedTamoxifen
DB00444ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedTeniposide
DB00342ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; withdrawnTerfenadine
DB04844ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedTetrabenazine
DB00759ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedTetracycline
DB01030ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalTopotecan
DB00755ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; nutraceutical; investigationalTretinoin
DB01339ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedVecuronium
DB01392ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedYohimbine
DB00363ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedClozapine
DB00445ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedEpirubicin
DB00285ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedVenlafaxine
DB00683ATP-binding cassette, sub-family B (MDR/TAP), member 1illicit; approvedMidazolam
DB00317ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalGefitinib
DB00993ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedAzathioprine
DB00661ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedVerapamil
DB00570ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedVinblastine
DB00530ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalErlotinib
DB01026ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalKetoconazole
DB00540ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedNortriptyline
DB00333ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedMethadone
DB01452ATP-binding cassette, sub-family B (MDR/TAP), member 1illicit; experimentalHeroin
DB01076ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedAtorvastatin
DB00439ATP-binding cassette, sub-family B (MDR/TAP), member 1withdrawnCerivastatin
DB00343ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedDiltiazem
DB01095ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedFluvastatin
DB01241ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedGemfibrozil
DB01167ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalItraconazole
DB00227ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalLovastatin
DB00175ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPravastatin
DB00503ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalRitonavir
DB01098ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedRosuvastatin
DB00996ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalGabapentin
DB00555ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalLamotrigine
DB01202ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalLevetiracetam
DB01174ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPhenobarbital
DB00472ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedFluoxetine
DB00252ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPhenytoin
DB00877ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalSirolimus
DB01169ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalArsenic trioxide
DB00950ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedFexofenadine
DB00316ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedAcetaminophen
DB00295ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalMorphine
DB00813ATP-binding cassette, sub-family B (MDR/TAP), member 1illicit; approved; investigationalFentanyl
DB00624ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalTestosterone
DB00352ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedThioguanine
DB00196ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedFluconazole
DB00958ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedCarboplatin
DB00199ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedErythromycin
DB00448ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalLansoprazole
DB01222ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalBudesonide
DB00641ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedSimvastatin
DB00889ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalGranisetron
DB00619ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedImatinib
DB00564ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalCarbamazepine
DB00987ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalCytarabine
DB01234ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalDexamethasone
DB00773ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedEtoposide
DB00650ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedLeucovorin
DB01033ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedMercaptopurine
DB00563ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedMethotrexate
DB00635ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPrednisone
DB00541ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalVincristine
DB00973ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedEzetimibe
DB01045ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedRifampin
DB00758ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; nutraceuticalClopidogrel
DB00864ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalTacrolimus
DB00358ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedMefloquine
DB01072ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalAtazanavir
DB01601ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedLopinavir
DB01232ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalSaquinavir
DB00531ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalCyclophosphamide
DB00734ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalRisperidone
DB00625ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalEfavirenz
DB00441ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedGemcitabine
DB00220ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedNelfinavir
DB00238ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedNevirapine
DB00313ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalValproic Acid
DB00390ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedDigoxin
DB01394ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedColchicine
DB00544ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedFluorouracil
DB00682ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedWarfarin
DB00334ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalOlanzapine
DB01016ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedGlyburide
DB00412ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalRosiglitazone
DB00331ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedMetformin
DB00688ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalMycophenolate mofetil
DB02587ATP-binding cassette, sub-family B (MDR/TAP), member 1experimentalForskolin
DB00457ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedPrazosin
DB01048ATP-binding cassette, sub-family B (MDR/TAP), member 1approved; investigationalAbacavir
DB00451ATP-binding cassette, sub-family B (MDR/TAP), member 1approvedLevothyroxine


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Cross referenced IDs for ABCB1
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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