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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for NUDT9 |
Basic gene info. | Gene symbol | NUDT9 |
Gene name | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | |
Synonyms | NUDT10 | |
Cytomap | UCSC genome browser: 4q22.1 | |
Genomic location | chr4 :88343727-88380606 | |
Type of gene | protein-coding | |
RefGenes | NM_001248011.1, NM_024047.4,NM_198038.2, | |
Ensembl id | ENSG00000170502 | |
Description | ADP-ribose diphosphataseADP-ribose phosphohydrolaseADP-ribose pyrophosphatase, mitochondrialADP-ribose pyrosphosphatase NUDT9ADPR-PPaseadenosine diphosphoribose pyrophosphatasenucleoside diphosphate linked moiety X-type motif 9 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606022 | |
HGNC : HGNC | ||
Ensembl : ENSG00000170502 | ||
HPRD : 09353 | ||
Vega : OTTHUMG00000130591 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NUDT9 | |
BioGPS: 53343 | ||
Gene Expression Atlas: ENSG00000170502 | ||
The Human Protein Atlas: ENSG00000170502 | ||
Pathway | NCI Pathway Interaction Database: NUDT9 | |
KEGG: NUDT9 | ||
REACTOME: NUDT9 | ||
ConsensusPathDB | ||
Pathway Commons: NUDT9 | ||
Metabolism | MetaCyc: NUDT9 | |
HUMANCyc: NUDT9 | ||
Regulation | Ensembl's Regulation: ENSG00000170502 | |
miRBase: chr4 :88,343,727-88,380,606 | ||
TargetScan: NM_001248011 | ||
cisRED: ENSG00000170502 | ||
Context | iHOP: NUDT9 | |
cancer metabolism search in PubMed: NUDT9 | ||
UCL Cancer Institute: NUDT9 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for NUDT9(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: NUDT9 |
Familial Cancer Database: NUDT9 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_PURINE_METABOLISM |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: NUDT9 |
MedGen: NUDT9 (Human Medical Genetics with Condition) | |
ClinVar: NUDT9 | |
Phenotype | MGI: NUDT9 (International Mouse Phenotyping Consortium) |
PhenomicDB: NUDT9 |
Mutations for NUDT9 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows NUDT9 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=18) | (# total SNVs=8) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr4:88356186-88356186 | p.S54F | 2 |
chr4:88356173-88356173 | p.V50L | 1 |
chr4:88359499-88359499 | p.Y140H | 1 |
chr4:88370351-88370351 | p.I196M | 1 |
chr4:88356175-88356175 | p.V50V | 1 |
chr4:88359517-88359517 | p.R146G | 1 |
chr4:88372753-88372753 | p.P219A | 1 |
chr4:88359518-88359518 | p.R146I | 1 |
chr4:88372763-88372763 | p.K222T | 1 |
chr4:88356213-88356213 | p.N63S | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 1 | 1 | 4 | 1 |   | 1 | 1 | 1 |   |   | 1 | 2 |   |   |   | 2 | 2 |   | 1 |
# mutation |   | 1 | 1 | 4 | 1 |   | 1 | 1 | 1 |   |   | 1 | 2 |   |   |   | 2 | 2 |   | 1 |
nonsynonymous SNV |   | 1 | 1 | 2 |   |   | 1 |   | 1 |   |   | 1 | 2 |   |   |   | 2 | 1 |   |   |
synonymous SNV |   |   |   | 2 | 1 |   |   | 1 |   |   |   |   |   |   |   |   |   | 1 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr4:88356180 | p.A101T,NUDT9 | 1 |
chr4:88375601 | p.W110C,NUDT9 | 1 |
chr4:88356186 | p.S118R,NUDT9 | 1 |
chr4:88378999 | p.Y140H,NUDT9 | 1 |
chr4:88356326 | p.N117N,NUDT9 | 1 |
chr4:88379014 | p.P118L,NUDT9 | 1 |
chr4:88356355 | p.R127W,NUDT9 | 1 |
chr4:88379089 | p.L129R,NUDT9 | 1 |
chr4:88359433 | p.R145R,NUDT9 | 1 |
chr4:88379168 | p.E258K,NUDT9 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for NUDT9 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AACS,ACSM1,AKR1D1,ALOX15B,B3GAT1,C15orf43,CBR4, CLDN8,FCN2,GGT1,ISX,LST-3TM12,LAMTOR3,MGST2, NDUFC1,NUDT9,RLN3,SCP2,SERHL,SLCO1B1,SULT1C3 | ACAA1,AIFM1,HYPK,DHRS7B,ELAC2,MRPL24,NDUFS6, NUDT9,PARK7,PDAP1,PFDN2,PSMB6,PSMC3,PSMD4, SIL1,SNAPC5,SOD1,SPR,VCP,WBSCR16,YKT6 | ||||
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AHSA1,ANAPC10,CASP6,COX16,EIF4E,ENOPH1,ERH, FKBP3,GAR1,INTS12,KLHL8,LARP7,LSM6,METAP1, NDUFC1,NEDD8,NUDT9,OCIAD1,GATB,PIGY,PPID | AGMAT,LINC00488,C9orf64,CISD1,CYP3A5,DLST,DNAJC25, FAH,FAM35A,FAM35BP,GATA5,GOLT1A,LGALSL,MAPK8, NPY6R,NR1H4,NUDT9,PIGH,PIP5K1A,UBA5,ZDHHC6 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for NUDT9 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB02379 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | experimental | Beta-D-Glucose | ![]() | ![]() |
DB04352 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | experimental | [(2r,3s,4s,5r)-3,4,5-Trihydroxytetrahydrofuran-2-Yl]Methyl Dihydrogen Phosphate | ![]() | ![]() |
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Cross referenced IDs for NUDT9 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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