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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for POLE2 |
Basic gene info. | Gene symbol | POLE2 |
Gene name | polymerase (DNA directed), epsilon 2, accessory subunit | |
Synonyms | DPE2 | |
Cytomap | UCSC genome browser: 14q21-q22 | |
Genomic location | chr14 :50116898-50155098 | |
Type of gene | protein-coding | |
RefGenes | NM_001197330.1, NM_001197331.1,NM_002692.3, | |
Ensembl id | ENSG00000100479 | |
Description | DNA polymerase II subunit 2DNA polymerase epsilon subunit 2DNA polymerase epsilon subunit Bpolymerase (DNA directed), epsilon 2 (p59 subunit) | |
Modification date | 20141207 | |
dbXrefs | MIM : 602670 | |
HGNC : HGNC | ||
Ensembl : ENSG00000100479 | ||
HPRD : 16007 | ||
Vega : OTTHUMG00000170813 | ||
Protein | UniProt: P56282 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POLE2 | |
BioGPS: 5427 | ||
Gene Expression Atlas: ENSG00000100479 | ||
The Human Protein Atlas: ENSG00000100479 | ||
Pathway | NCI Pathway Interaction Database: POLE2 | |
KEGG: POLE2 | ||
REACTOME: POLE2 | ||
ConsensusPathDB | ||
Pathway Commons: POLE2 | ||
Metabolism | MetaCyc: POLE2 | |
HUMANCyc: POLE2 | ||
Regulation | Ensembl's Regulation: ENSG00000100479 | |
miRBase: chr14 :50,116,898-50,155,098 | ||
TargetScan: NM_001197330 | ||
cisRED: ENSG00000100479 | ||
Context | iHOP: POLE2 | |
cancer metabolism search in PubMed: POLE2 | ||
UCL Cancer Institute: POLE2 | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for POLE2(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: POLE2 |
Familial Cancer Database: POLE2 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_PURINE_METABOLISM KEGG_PYRIMIDINE_METABOLISM |
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OMIM | 602670; gene. |
Orphanet | |
Disease | KEGG Disease: POLE2 |
MedGen: POLE2 (Human Medical Genetics with Condition) | |
ClinVar: POLE2 | |
Phenotype | MGI: POLE2 (International Mouse Phenotyping Consortium) |
PhenomicDB: POLE2 |
Mutations for POLE2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
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- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | POLE2 | chr14 | 50124682 | 50124702 | LRR1 | chr14 | 50078557 | 50078577 |
ovary | POLE2 | chr14 | 50124684 | 50124704 | LRR1 | chr14 | 50078557 | 50078577 |
ovary | POLE2 | chr14 | 50124691 | 50124711 | LRR1 | chr14 | 50078565 | 50078585 |
pancreas | POLE2 | chr14 | 50126261 | 50126281 | POLE2 | chr14 | 50126324 | 50126344 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows POLE2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=22) | (# total SNVs=13) |
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(# total SNVs=2) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:50117145-50117145 | p.I445M | 3 |
chr14:50140860-50140860 | p.R133Q | 2 |
chr14:50120778-50120778 | p.L381F | 2 |
chr14:50118023-50118023 | p.V428V | 2 |
chr14:50122404-50122404 | p.R305C | 2 |
chr14:50146467-50146467 | p.C74F | 2 |
chr14:50133134-50133134 | p.? | 2 |
chr14:50150360-50150360 | p.E40D | 1 |
chr14:50118061-50118061 | p.R416C | 1 |
chr14:50130032-50130032 | p.? | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 3 | 2 |   | 6 | 1 |   | 2 |   | 2 |   | 1 | 1 | 1 | 2 |   |   | 2 | 5 |   | 4 |
# mutation | 3 | 2 |   | 7 | 1 |   | 2 |   | 2 |   | 1 | 1 | 1 | 2 |   |   | 2 | 5 |   | 4 |
nonsynonymous SNV | 1 | 1 |   | 5 | 1 |   | 1 |   | 1 |   |   | 1 | 1 | 2 |   |   | 2 | 4 |   | 3 |
synonymous SNV | 2 | 1 |   | 2 |   |   | 1 |   | 1 |   | 1 |   |   |   |   |   |   | 1 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:50117145 | p.R107Q,POLE2 | 2 |
chr14:50140860 | p.R279C,POLE2 | 2 |
chr14:50118023 | p.I419I,POLE2 | 2 |
chr14:50122404 | p.V402V,POLE2 | 2 |
chr14:50136312 | p.I386L,POLE2 | 1 |
chr14:50122474 | p.T115N,POLE2 | 1 |
chr14:50118020 | p.L355F,POLE2 | 1 |
chr14:50131378 | p.P354S,POLE2 | 1 |
chr14:50140867 | p.R105C,POLE2 | 1 |
chr14:50131391 | p.P339S,POLE2 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for POLE2 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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CCNB1,CDKN3,DLGAP5,ERCC6L,GINS1,HELLS,KIF11, KIF4A,LMNB1,NCAPG,NCAPH,OIP5,PARP2,PCNA, POLE2,LRR1,SCAF11___GEMIN2___ZEB2,SPC25,TPX2,VRK1,WDHD1 | PARPBP,CENPH,CENPK,E2F5,FANCD2,FANCI,FBXO5, GINS1,GINS4,HELLS,KIF18A,MAD2L1,PAICS,PLK4, POLE2,RFC3,SRPK1,STIL,TDP1,ZNF93,ZWILCH | ||||
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ASF1B,EFCAB11,CDCA4,CDKN3,CHEK1,DLGAP5,EIF2S1, ERH,FANCM,MCM6,MTHFD1,NCAPH,PARP2,POLE2, LRR1,PRIM1,PSMA3,RFC4,RFC5,VRK1,WDHD1 | DDIAS,DBF4,EIF4A1,EIF5AL1,GINS1,GINS2,H2AFZ, HNRNPF,KIAA0101,NME1,PCNA,POLE2,PSMD14,RAD51AP1, RAN,RANBP1,RFC3,RFC4,SNRPD1,UBE2T,VRK1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for POLE2 |
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DB Category | DB Name | DB's ID and Url link |
Organism-specific databases | PharmGKB | PA278; -. |
Organism-specific databases | CTD | 5427; -. |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00242 | polymerase (DNA directed), epsilon 2, accessory subunit | approved; investigational | Cladribine | ![]() | ![]() |
DB01050 | polymerase (DNA directed), epsilon 2, accessory subunit | approved | Ibuprofen | ![]() | ![]() |
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Cross referenced IDs for POLE2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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