Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for HAO1

Basic gene info.	Gene symbol	HAO1
	Gene name	hydroxyacid oxidase (glycolate oxidase) 1
	Synonyms	GOX\|GOX1\|HAOX1
	Cytomap	UCSC genome browser: 20p12
	Genomic location	chr20 :7863630-7921093
	Type of gene	protein-coding
	RefGenes	NM_017545.2,
	Ensembl id	ENSG00000101323
	Description	(S)-2-hydroxy-acid oxidaseglycolate oxidasehydroxyacid oxidase 1
	Modification date	20141207
dbXrefs	MIM : 605023
	HGNC : HGNC
	Ensembl : ENSG00000101323
	HPRD : 05429
	Vega : OTTHUMG00000031841
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HAO1
	BioGPS: 54363
	Gene Expression Atlas: ENSG00000101323
	The Human Protein Atlas: ENSG00000101323
Pathway	NCI Pathway Interaction Database: HAO1
	KEGG: HAO1
	REACTOME: HAO1
	ConsensusPathDB
	Pathway Commons: HAO1
Metabolism	MetaCyc: HAO1
	HUMANCyc: HAO1
Regulation	Ensembl's Regulation: ENSG00000101323
	miRBase: chr20 :7,863,630-7,921,093
	TargetScan: NM_017545
	cisRED: ENSG00000101323
Context	iHOP: HAO1
	cancer metabolism search in PubMed: HAO1
	UCL Cancer Institute: HAO1
Assigned class in ccmGDB	C

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Phenotypic Information for HAO1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: HAO1
	Familial Cancer Database: HAO1

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES

Others
OMIM
Orphanet
Disease	KEGG Disease: HAO1
	MedGen: HAO1 (Human Medical Genetics with Condition)
	ClinVar: HAO1
Phenotype	MGI: HAO1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: HAO1

Mutations for HAO1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

- Statistics for Tissue and Mutation type

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- For Inter-chromosomal Variations

There's no inter-chromosomal structural variation.

- For Intra-chromosomal Variations

* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.

Sample	Symbol_a	Chr_a	Start_a	End_a	Symbol_b	Chr_b	Start_b	End_b
pancreas	HAO1	chr20	7902358	7902378	HAO1	chr20	7902905	7902925

cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows HAO1 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=59)	Stat. for Synonymous SNVs (# total SNVs=11)

Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr20:7864254-7864254	p.V367F	4
chr20:7894923-7894923	p.R145W	3
chr20:7864303-7864303	p.Q350H	2
chr20:7895041-7895041	p.M105I	2
chr20:7886880-7886880	p.D214E	2
chr20:7866189-7866189	p.R341W	2
chr20:7915149-7915149	p.E91K	2
chr20:7894842-7894842	p.R172C	2
chr20:7921052-7921052	p.I6M	2
chr20:7875841-7875841	p.G251D	2

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	4	1	12	2		7				1	10	6	3		1	7	9		4
# mutation	1	4	1	10	2		7				1	10	6	3		1	6	9		4
nonsynonymous SNV	1	4	1	6	2		5					7	6	3		1	5	4		4
synonymous SNV				4			2				1	3					1	5

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr20:7894842	p.R172C	3
chr20:7895041	p.M105I	2
chr20:7875861	p.L333F	1
chr20:7915257	p.V268M	1
chr20:7866210	p.Q180E	1
chr20:7886933	p.T64P	1
chr20:7866414	p.Q324H	1
chr20:7915152	p.G254W	1
chr20:7875863	p.P179L	1
chr20:7915261	p.S63L	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for HAO1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for HAO1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ANXA2P3,LINC00479,CLDN6,DTD1,HAO1,HFM1,KRTAP2-1, KRTAP2-2,LECT1,LOC340094,LINC00493,MATN4,LINC00112,LINC00113, OR10W1,POLR3F,SNRPB2,SPTA1,SUGT1,TM2D2,ZIC3	GLIS3-AS1,ERAS,F2RL2,FAM136A,FAM138E,EVA1A,FMO1, FZD10,HAO1,LOC282997,MAGED4,MIR503HG,NRXN2,OBP2A, PSD,SAAL1,SCG5,TBC1D7,TCEAL5,TMEM158,XPNPEP1

CRCT1,CRNN,HAO1,IL36A,KRT14,KRT6A,KRT6C, KRT78,CERS3,LCE3D,LCE3E,MRGPRX3,SBSN,SDR9C7, SERPINB13,SPRR2A,SPRR2B,SPRR2C,SPRR2E,TGM1,TMPRSS11F	ALB,APCS,APOA2,C3P1,C8A,CFHR2,CFHR5, CYP4A22,DNAJB8,F13B,F9,FGG,HAO1,KIR3DP1, KRTAP4-11,KRTAP5-3,LECT2,LOC100129935,LINC00160,OR1N1,SLC17A2

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for HAO1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB02164	hydroxyacid oxidase (glycolate oxidase) 1	experimental	N-Sulfo-Flavin Mononucleotide
DB02279	hydroxyacid oxidase (glycolate oxidase) 1	experimental	Benzoylformic Acid
DB03014	hydroxyacid oxidase (glycolate oxidase) 1	experimental	Heme
DB03064	hydroxyacid oxidase (glycolate oxidase) 1	experimental	3-Decyl-2,5-Dioxo-4-Hydroxy-3-Pyrroline
DB03247	hydroxyacid oxidase (glycolate oxidase) 1	experimental	Riboflavin Monophosphate
DB03884	hydroxyacid oxidase (glycolate oxidase) 1	experimental	3-Phenylpyruvic Acid
DB04374	hydroxyacid oxidase (glycolate oxidase) 1	experimental	4-Carboxy-5-(1-Pentyl)Hexylsulfanyl-1,2,3-Triazole
DB06979	hydroxyacid oxidase (glycolate oxidase) 1	experimental	5-(dodecylthio)-1H-1,2,3-triazole-4-carboxylic acid
DB07060	hydroxyacid oxidase (glycolate oxidase) 1	experimental	3-(INDOL-3-YL) LACTATE
DB07907	hydroxyacid oxidase (glycolate oxidase) 1	experimental	(2S)-2-HYDROXYOCTANOIC ACID
DB00145	hydroxyacid oxidase (glycolate oxidase) 1	approved; nutraceutical	Glycine
DB00160	hydroxyacid oxidase (glycolate oxidase) 1	approved; nutraceutical	L-Alanine

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Cross referenced IDs for HAO1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information