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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for POLR2L |
Basic gene info. | Gene symbol | POLR2L |
Gene name | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | |
Synonyms | RBP10|RPABC5|RPB10|RPB10beta|RPB7.6|hRPB7.6 | |
Cytomap | UCSC genome browser: 11p15 | |
Genomic location | chr11 :839720-842529 | |
Type of gene | protein-coding | |
RefGenes | NM_021128.4, | |
Ensembl id | ENSG00000177700 | |
Description | DNA-directed RNA polymerase III subunit LDNA-directed RNA polymerases I, II, and III subunit RPABC5RNA polymerase II 7.6 kDa subunitRNA polymerases I, II, and III subunit ABC5RPB10 homolog | |
Modification date | 20141207 | |
dbXrefs | MIM : 601189 | |
HGNC : HGNC | ||
Ensembl : ENSG00000177700 | ||
HPRD : 01155 | ||
Vega : OTTHUMG00000133316 | ||
Protein | UniProt: P62875 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_POLR2L | |
BioGPS: 5441 | ||
Gene Expression Atlas: ENSG00000177700 | ||
The Human Protein Atlas: ENSG00000177700 | ||
Pathway | NCI Pathway Interaction Database: POLR2L | |
KEGG: POLR2L | ||
REACTOME: POLR2L | ||
ConsensusPathDB | ||
Pathway Commons: POLR2L | ||
Metabolism | MetaCyc: POLR2L | |
HUMANCyc: POLR2L | ||
Regulation | Ensembl's Regulation: ENSG00000177700 | |
miRBase: chr11 :839,720-842,529 | ||
TargetScan: NM_021128 | ||
cisRED: ENSG00000177700 | ||
Context | iHOP: POLR2L | |
cancer metabolism search in PubMed: POLR2L | ||
UCL Cancer Institute: POLR2L | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for POLR2L(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: POLR2L |
Familial Cancer Database: POLR2L |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_PURINE_METABOLISM KEGG_PYRIMIDINE_METABOLISM |
Others | |
OMIM | 601189; gene. |
Orphanet | |
Disease | KEGG Disease: POLR2L |
MedGen: POLR2L (Human Medical Genetics with Condition) | |
ClinVar: POLR2L | |
Phenotype | MGI: POLR2L (International Mouse Phenotyping Consortium) |
PhenomicDB: POLR2L |
Mutations for POLR2L |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows POLR2L related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=3) | (# total SNVs=4) |
(# total SNVs=0) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr11:840477-840477 | p.D33D | 3 |
chr11:842499-842499 | p.P4S | 3 |
chr11:840428-840428 | p.L50L | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   |   |   |   | 1 |   |   | 1 |   |   |   |   |   |   | 1 |   |   |   |
# mutation |   |   |   |   |   |   | 1 |   |   | 1 |   |   |   |   |   |   | 1 |   |   |   |
nonsynonymous SNV |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   | 1 |   |   |   |
synonymous SNV |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr11:840420 | p.H52Q | 1 |
chr11:840428 | p.L50L | 1 |
chr11:840466 | p.A37D | 1 |
Other DBs for Point Mutations |
Copy Number for POLR2L in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for POLR2L |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ALKBH7,ARL6IP4,TSR3,C19orf24,LAMTOR4,CHCHD5,EDF1, FAM173A,FBXL15,FIS1,MRPL23,MRPL53,MRPL54,NME3, NUDT22,PHPT1,POLR2L,STUB1,TMEM160,TSSC4,UQCR11 | AP1M1,ARL2,BCAP31,BLOC1S1,CCDC107,CD63,GPX1, GPX4,HINT2,LGALS1,LRP3,MRPS11,MYL6,NDUFAF3, PHLDA3,POLR2E,POLR2L,PSMD8,RNPEPL1,TST,UROD |
ATP5D,AURKAIP1,UQCC3,CENPM,COPE,EIF5A,EIF5AL1, GADD45GIP1,HMBS,NAA38,MRPL20,MRPL54,MRPS34,NDUFS3, POLR2L,PSMD9,RPS6KB2,SERF2,SIVA1,SSSCA1,STRA13 | TMEM258,HYPK,CCDC167,GADD45GIP1,MRPL20,MRPL51,MRPL52, MYEOV2,NDUFA7,NEDD8,PFDN6,POLR2L,PSMA7,PSMB1, PSMB4,PSMB6,PSMB7,PSMD13,PSMD8,RBX1,SNRPC |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for POLR2L |
There's no related Drug. |
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Cross referenced IDs for POLR2L |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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