|
Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for FBXW5 |
Top |
Phenotypic Information for FBXW5(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: FBXW5 |
Familial Cancer Database: FBXW5 |
* This gene is included in those cancer gene databases. |
. | ||||||||||||||||||||
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | 609072; gene. 609072; gene. |
Orphanet | |
Disease | KEGG Disease: FBXW5 |
MedGen: FBXW5 (Human Medical Genetics with Condition) | |
ClinVar: FBXW5 | |
Phenotype | MGI: FBXW5 (International Mouse Phenotyping Consortium) |
PhenomicDB: FBXW5 |
Mutations for FBXW5 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows FBXW5 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BE832990 | FBXW5 | 32 | 82 | 9 | 139835137 | 139835187 | PSMB10 | 78 | 133 | 16 | 67970327 | 67970383 |
Other DBs for Structural Variants |
Top |
Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
Top |
SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
|
Top |
Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=28) | (# total SNVs=6) |
(# total SNVs=0) | (# total SNVs=0) |
Top |
Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr9:139835816-139835816 | p.F448F | 2 |
chr9:139837929-139837929 | p.R75R | 2 |
chr9:139836018-139836018 | p.I405I | 2 |
chr9:139836527-139836527 | p.G356D | 1 |
chr9:139836904-139836904 | p.E230E | 1 |
chr9:139835484-139835484 | p.A533T | 1 |
chr9:139835803-139835803 | p.M453V | 1 |
chr9:139837823-139837823 | p.C110Y | 1 |
chr9:139836545-139836545 | p.Y350F | 1 |
chr9:139837005-139837005 | p.A223A | 1 |
Top |
SNV Counts per Each Loci in TCGA data |
|
Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 |   |   | 6 |   |   |   |   | 1 | 1 |   | 1 | 2 |   |   |   | 2 | 3 |   | 9 |
# mutation | 2 |   |   | 6 |   |   |   |   | 1 | 1 |   | 1 | 2 |   |   |   | 2 | 3 |   | 10 |
nonsynonymous SNV | 2 |   |   | 3 |   |   |   |   | 1 | 1 |   | 1 | 2 |   |   |   | 1 | 2 |   | 8 |
synonymous SNV |   |   |   | 3 |   |   |   |   |   |   |   |   |   |   |   |   | 1 | 1 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
Top |
Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr9:139837324 | p.L201L | 1 |
chr9:139835488 | p.V484L | 1 |
chr9:139836545 | p.E169K | 1 |
chr9:139837342 | p.D470D | 1 |
chr9:139835553 | p.F143C | 1 |
chr9:139836636 | p.D470G | 1 |
chr9:139837370 | p.T141T | 1 |
chr9:139835710 | p.A462V | 1 |
chr9:139836644 | p.A440T | 1 |
chr9:139837920 | p.P135P | 1 |
Other DBs for Point Mutations |
Copy Number for FBXW5 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
Top |
Gene Expression for FBXW5 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
Top |
CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
Top |
Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ANAPC2,C9orf142,ARRDC1-AS1,C9orf69,RABL6,NELFB,EDF1, FBXL15,FBXW5,GUK1,MBD3,NDOR1,NDUFS7,PHPT1, PLEKHJ1,PMPCA,PTGES2,SNAPC4,SSNA1,TMUB1,TRAF2 | AKT1S1,ANAPC11,AP2A1,CDC34,FBXW5,GPS1,ISOC2, MRPL12,MRPL2,MRPL38,MRPL41,MRPL53,MRPS11,NDUFA13, NDUFB7,NDUFB8,NDUFS8,SLC2A4RG,TIMM50,TWF2,VPS4A |
CDK9,NELFB,COQ4,ECI1,EDF1,FBXW5,MAN1B1, MRPL41,NANS,NPDC1,PPP2R4,RILP,SGSM3,SH3GLB2, SIGIRR,SLC27A4,STARD10,SURF4,TOR2A,ZDHHC12,ZFYVE19 | B3GALT4,CHMP1A,CTSD,EPN1,FBXW5,HPS1,KIAA2013, MAP2K2,MAP3K11,MGAT4B,MPND,NAGPA,NAA60,PEX16, RAB11B,RILP,RNPEPL1,STARD3,TMEM175,TNIP2,TRAF7 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
Top |
Interacting Genes (from Pathway Commons) |
Top |
Pharmacological Information for FBXW5 |
There's no related Drug. |
Top |
Cross referenced IDs for FBXW5 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @ |