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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for UGT1A8 |
Basic gene info. | Gene symbol | UGT1A8 |
Gene name | UDP glucuronosyltransferase 1 family, polypeptide A8 | |
Synonyms | UDPGT|UDPGT 1-8|UGT-1H|UGT1-08|UGT1.8|UGT1A8S|UGT1H | |
Cytomap | UCSC genome browser: 2q37 | |
Genomic location | chr2 :234526290-234681945 | |
Type of gene | protein-coding | |
RefGenes | NM_019076.4, | |
Ensembl id | ENSG00000242366 | |
Description | UDP glycosyltransferase 1 family, polypeptide A8UDP-glucuronosyltransferase 1 family polypeptide A8sUDP-glucuronosyltransferase 1-8UDP-glucuronosyltransferase 1-HUDP-glucuronosyltransferase 1A8 | |
Modification date | 20141211 | |
dbXrefs | MIM : 606433 | |
HGNC : HGNC | ||
Ensembl : ENSG00000242366 | ||
HPRD : 07072 | ||
Vega : OTTHUMG00000059123 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_UGT1A8 | |
BioGPS: 54576 | ||
Gene Expression Atlas: ENSG00000242366 | ||
The Human Protein Atlas: ENSG00000242366 | ||
Pathway | NCI Pathway Interaction Database: UGT1A8 | |
KEGG: UGT1A8 | ||
REACTOME: UGT1A8 | ||
ConsensusPathDB | ||
Pathway Commons: UGT1A8 | ||
Metabolism | MetaCyc: UGT1A8 | |
HUMANCyc: UGT1A8 | ||
Regulation | Ensembl's Regulation: ENSG00000242366 | |
miRBase: chr2 :234,526,290-234,681,945 | ||
TargetScan: NM_019076 | ||
cisRED: ENSG00000242366 | ||
Context | iHOP: UGT1A8 | |
cancer metabolism search in PubMed: UGT1A8 | ||
UCL Cancer Institute: UGT1A8 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for UGT1A8(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: UGT1A8 |
Familial Cancer Database: UGT1A8 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_ASCORBATE_AND_ALDARATE_METABOLISM KEGG_STARCH_AND_SUCROSE_METABOLISM KEGG_RETINOL_METABOLISM KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_OTHER_ENZYMES |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: UGT1A8 |
MedGen: UGT1A8 (Human Medical Genetics with Condition) | |
ClinVar: UGT1A8 | |
Phenotype | MGI: UGT1A8 (International Mouse Phenotyping Consortium) |
PhenomicDB: UGT1A8 |
Mutations for UGT1A8 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGT1A8 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BQ233134 | MLL | 1 | 436 | 11 | 118367308 | 118367743 | UGT1A8 | 428 | 449 | 2 | 234629380 | 234629401 | |
J04093 | UGT1A8 | 1 | 82 | 2 | 234601557 | 234601638 | UGT1A8 | 79 | 2422 | 2 | 234601642 | 234681945 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   | 1 |   |   | 2 |   | 2 |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   | 1 |   |   | 1 |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   | 1 |   | 1 |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=58) | (# total SNVs=19) |
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(# total SNVs=4) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr2:234526363-234526363 | p.T4A | 6 |
chr2:234681161-234681161 | p.K517E | 3 |
chr2:234676526-234676526 | p.S340L | 3 |
chr2:234681095-234681095 | p.V495I | 2 |
chr2:234677057-234677057 | p.A423T | 2 |
chr2:234681146-234681146 | p.R512W | 2 |
chr2:234526745-234526745 | p.R131Q | 2 |
chr2:234526585-234526585 | p.S78P | 2 |
chr2:234527113-234527113 | p.R254* | 2 |
chr2:234681041-234681041 | p.D477N | 2 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   | 2 |   | 4 | 1 |   | 3 |   |   |   |   | 3 | 3 | 1 |   |   | 9 | 2 |   | 5 |
# mutation |   | 2 |   | 3 | 1 |   | 3 |   |   |   |   | 3 | 3 | 1 |   |   | 11 | 2 |   | 5 |
nonsynonymous SNV |   | 1 |   | 2 | 1 |   | 2 |   |   |   |   | 1 | 3 | 1 |   |   | 7 | 1 |   | 5 |
synonymous SNV |   | 1 |   | 1 |   |   | 1 |   |   |   |   | 2 |   |   |   |   | 4 | 1 |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr2:234526585 | p.S78P | 2 |
chr2:234526854 | p.A23P | 1 |
chr2:234526397 | p.A152A | 1 |
chr2:234527158 | p.G26G | 1 |
chr2:234526661 | p.G154C | 1 |
chr2:234526865 | p.V30V | 1 |
chr2:234526407 | p.L163L | 1 |
chr2:234527192 | p.G35R | 1 |
chr2:234526664 | p.V167V | 1 |
chr2:234526902 | p.K47T | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for UGT1A8 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AIMP1,AMBN,ASTN1,CPA4,FBLN7,FTMT,GABRB1, IAPP,INSL5,KCNJ16,LAMB4,LEPREL1,LRRCC1,NCALD, NECAB2,PROL1,RERGL,RNLS,S100A4,TFAP2E,UGT1A8 | ADH7,AKR1B10,ALDH3A1,C10orf99,CAPNS2,CYP4F3,GJB6, IL36RN,KRT13,KRT4,KRT6A,KRT78,KRTDAP,SOX2, SPRR1A,SPRR2A,SPRR2D,SPRR3,UGT1A7,UGT1A8,UPK1B | ||||
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AKR1B10,MIEN1,CASC3,CDC6,ERBB2,MED24,MSL1, ORMDL3,PGAP3,PPP1R1B,PSMD3,RAPGEFL1,RARA,SNX32, TCAP,THRA,UGT1A10,UGT1A6,UGT1A8,UGT1A9,WIPF2 | ABHD5,AGFG2,RHOV___CHP1,CUL3,EHHADH,HMGB3,IQGAP2, KIFAP3,NAALADL2,NDUFS2,OPN3,PAPSS2,RTN3,SLC16A1, STK38,TFRC,TGFA,UGDH,UGT1A10,UGT1A8,VDAC1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for UGT1A8 |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01024 | UDP glucuronosyltransferase 1 family, polypeptide A8 | approved | Mycophenolic acid | ![]() | ![]() |
DB00877 | UDP glucuronosyltransferase 1 family, polypeptide A8 | approved; investigational | Sirolimus | ![]() | ![]() |
DB00864 | UDP glucuronosyltransferase 1 family, polypeptide A8 | approved; investigational | Tacrolimus | ![]() | ![]() |
DB00184 | UDP glucuronosyltransferase 1 family, polypeptide A8 | approved | Nicotine | ![]() | ![]() |
DB00295 | UDP glucuronosyltransferase 1 family, polypeptide A8 | approved; investigational | Morphine | ![]() | ![]() |
DB00318 | UDP glucuronosyltransferase 1 family, polypeptide A8 | illicit; approved | Codeine | ![]() | ![]() |
DB00818 | UDP glucuronosyltransferase 1 family, polypeptide A8 | approved; investigational | Propofol | ![]() | ![]() |
DB00688 | UDP glucuronosyltransferase 1 family, polypeptide A8 | approved; investigational | Mycophenolate mofetil | ![]() | ![]() |
DB00762 | UDP glucuronosyltransferase 1 family, polypeptide A8 | approved; investigational | Irinotecan | ![]() | ![]() |
DB00655 | UDP glucuronosyltransferase 1 family, polypeptide A8 | approved | Estrone | ![]() | ![]() |
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Cross referenced IDs for UGT1A8 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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