Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for UGT1A6

Basic gene info.	Gene symbol	UGT1A6
	Gene name	UDP glucuronosyltransferase 1 family, polypeptide A6
	Synonyms	GNT1\|HLUGP\|HLUGP1\|UDPGT\|UDPGT 1-6\|UGT1\|UGT1A6S\|UGT1F
	Cytomap	UCSC genome browser: 2q37
	Genomic location	chr2 :234600320-234681945
	Type of gene	protein-coding
	RefGenes	NM_001072.3, NM_205862.1,
	Ensembl id	ENSG00000167165
	Description	UDP glycosyltransferase 1 family, polypeptide A6UDP-glucuronosyltransferase 1 family polypeptide A6sUDP-glucuronosyltransferase 1-6UDP-glucuronosyltransferase 1-FUDP-glucuronosyltransferase 1A6UGT-1FUGT1*6UGT1-06UGT1.6phenol-metabolizing UDP-gluc
	Modification date	20141211
dbXrefs	MIM : 606431
	HGNC : HGNC
	Ensembl : ENSG00000167165
	HPRD : 07071
	Vega : OTTHUMG00000059122
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_UGT1A6
	BioGPS: 54578
	Gene Expression Atlas: ENSG00000167165
	The Human Protein Atlas: ENSG00000167165
Pathway	NCI Pathway Interaction Database: UGT1A6
	KEGG: UGT1A6
	REACTOME: UGT1A6
	ConsensusPathDB
	Pathway Commons: UGT1A6
Metabolism	MetaCyc: UGT1A6
	HUMANCyc: UGT1A6
Regulation	Ensembl's Regulation: ENSG00000167165
	miRBase: chr2 :234,600,320-234,681,945
	TargetScan: NM_001072
	cisRED: ENSG00000167165
Context	iHOP: UGT1A6
	cancer metabolism search in PubMed: UGT1A6
	UCL Cancer Institute: UGT1A6
Assigned class in ccmGDB	C

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Phenotypic Information for UGT1A6(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: UGT1A6
	Familial Cancer Database: UGT1A6

* This gene is included in those cancer gene databases.

						.
Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_ASCORBATE_AND_ALDARATE_METABOLISM KEGG_STARCH_AND_SUCROSE_METABOLISM KEGG_RETINOL_METABOLISM KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_OTHER_ENZYMES

Others
OMIM
Orphanet
Disease	KEGG Disease: UGT1A6
	MedGen: UGT1A6 (Human Medical Genetics with Condition)
	ClinVar: UGT1A6
Phenotype	MGI: UGT1A6 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: UGT1A6

Mutations for UGT1A6

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGT1A6 related fusion information.

Head Gene

Tail Gene

Accession

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Gene_a

qStart_a

qEnd_a

Chromosome_a

tStart_a

tEnd_a

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=4

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=55)	Stat. for Synonymous SNVs (# total SNVs=23)

Stat. for Deletions (# total SNVs=2)	Stat. for Insertions (# total SNVs=0)
	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr2:234676526-234676526	p.S342L	3
chr2:234602272-234602272	p.R208*	3
chr2:234681161-234681161	p.K519E	3
chr2:234680936-234680936	p.S444G	2
chr2:234602202-234602202	p.R184S	2
chr2:234675694-234675694	p.Y292Y	2
chr2:234676536-234676536	p.A345A	2
chr2:234681013-234681013	p.G469G	2
chr2:234681080-234681080	p.G492S	2
chr2:234601669-234601669	p.S7A	2

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample	1	2		2	1		2		1			6	1				8	3		6
# mutation	1	2		2	1		2		1			6	1				8	3		6
nonsynonymous SNV	1	2		1	1		1		1			6	1				4	1		4
synonymous SNV				1			1										4	2		2

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr2:234602064	p.F138L	2
chr2:234602022	p.P264S	1
chr2:234602187	p.F171Y	1
chr2:234602454	p.M268I,UGT1A6	1
chr2:234602275	p.F171F	1
chr2:234602466	p.V272V,UGT1A6	1
chr2:234602084	p.R172G	1
chr2:234602290	p.D284Y,UGT1A6	1
chr2:234602500	p.M1I	1
chr2:234601653	p.F174F	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for UGT1A6 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for UGT1A6

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


AKR1B10,AKR1C1,AKR1C3,ALDH3A1,C20orf196,DNAJB3,G6PD, GAGE2B,GPX2,IQCF2,LOC285629,RBMXL2,SPTLC3,TRIM16L, UGT1A1,UGT1A3,UGT1A5,UGT1A6,UGT1A9,VCX,VCX3A	ADH7,AKR1B10,ALDH3A1,LINC01559,CYP4F3,GJB4,GJB6, GPR115,KRT13,KRT4,KRT6A,SERPINB3,SOX2,SPRR1A, SPRR2A,SPRR3,TMPRSS4,UGT1A10,UGT1A6,UPK1B,XKRX

AATF,MIEN1,ERBB2,FXYD2,GRB7,KCNA10,MED24, ORMDL3,OSGIN1,PGAP3,PPP1R1B,PSMD3,RGSL1,SNAR-A2, STARD3,THRA,UGT1A10,UGT1A6,UGT1A7,UGT1A8,UGT1A9	ABHD13,RGCC,C16orf87,C1orf100,C2orf69,CAAP1,COX11, CREM,CSN1S1,DNTTIP2,DRD5,EIF1B,LHFPL3,LOC100302650, RAP2C,RPSAP52,RWDD4,SLC25A16,UGT1A6,USP45,WTAP

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for UGT1A6

Cross-referenced pharmacological DB IDs from Uniprot

DB Category

DB Name

DB's ID and Url link

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00252	UDP glucuronosyltransferase 1 family, polypeptide A6	approved	Phenytoin
DB00184	UDP glucuronosyltransferase 1 family, polypeptide A6	approved	Nicotine
DB00313	UDP glucuronosyltransferase 1 family, polypeptide A6	approved; investigational	Valproic Acid
DB00316	UDP glucuronosyltransferase 1 family, polypeptide A6	approved	Acetaminophen
DB00945	UDP glucuronosyltransferase 1 family, polypeptide A6	approved	Acetylsalicylic acid
DB00762	UDP glucuronosyltransferase 1 family, polypeptide A6	approved; investigational	Irinotecan
DB00783	UDP glucuronosyltransferase 1 family, polypeptide A6	approved; investigational	Estradiol
DB00338	UDP glucuronosyltransferase 1 family, polypeptide A6	approved; investigational	Omeprazole
DB00788	UDP glucuronosyltransferase 1 family, polypeptide A6	approved	Naproxen

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Cross referenced IDs for UGT1A6

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information