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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for UGT1A9 |
Basic gene info. | Gene symbol | UGT1A9 |
Gene name | UDP glucuronosyltransferase 1 family, polypeptide A9 | |
Synonyms | HLUGP4|LUGP4|UDPGT|UDPGT 1-9|UGT-1I|UGT1-09|UGT1-9|UGT1.9|UGT1AI|UGT1I | |
Cytomap | UCSC genome browser: 2q37 | |
Genomic location | chr2 :234580543-234681951 | |
Type of gene | protein-coding | |
RefGenes | NM_021027.2, | |
Ensembl id | ENSG00000241119 | |
Description | UDP glycosyltransferase 1 family, polypeptide A9UDP-glucuronosyltransferase 1-9UDP-glucuronosyltransferase 1-IUDP-glucuronosyltransferase 1A9 | |
Modification date | 20141222 | |
dbXrefs | MIM : 606434 | |
HGNC : HGNC | ||
Ensembl : ENSG00000241119 | ||
HPRD : 07073 | ||
Vega : OTTHUMG00000059124 | ||
Protein | UniProt: O60656 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_UGT1A9 | |
BioGPS: 54600 | ||
Gene Expression Atlas: ENSG00000241119 | ||
The Human Protein Atlas: ENSG00000241119 | ||
Pathway | NCI Pathway Interaction Database: UGT1A9 | |
KEGG: UGT1A9 | ||
REACTOME: UGT1A9 | ||
ConsensusPathDB | ||
Pathway Commons: UGT1A9 | ||
Metabolism | MetaCyc: UGT1A9 | |
HUMANCyc: UGT1A9 | ||
Regulation | Ensembl's Regulation: ENSG00000241119 | |
miRBase: chr2 :234,580,543-234,681,951 | ||
TargetScan: NM_021027 | ||
cisRED: ENSG00000241119 | ||
Context | iHOP: UGT1A9 | |
cancer metabolism search in PubMed: UGT1A9 | ||
UCL Cancer Institute: UGT1A9 | ||
Assigned class in ccmGDB | A - This gene has a literature evidence and it belongs to cancer gene. | |
References showing role of UGT1A9 in cancer cell metabolism | 1. Wassenaar CA, Conti DV, Das S, Chen P, Cook EH, et al. (2015) UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in European and African American smokers. Cancer Epidemiology Biomarkers & Prevention 24: 94-104. go to article 2. Laverdiere I, Flageole C, Audet-Walsh É, Caron P, Fradet Y, et al. (2015) The UGT1 locus is a determinant of prostate cancer recurrence after prostatectomy. Endocrine-related cancer 22: 77-85. go to article |
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Phenotypic Information for UGT1A9(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: UGT1A9 |
Familial Cancer Database: UGT1A9 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_ASCORBATE_AND_ALDARATE_METABOLISM KEGG_STARCH_AND_SUCROSE_METABOLISM KEGG_RETINOL_METABOLISM KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_CYTOCHROME_P450 KEGG_DRUG_METABOLISM_OTHER_ENZYMES REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | 191740; gene. 606434; gene. |
Orphanet | |
Disease | KEGG Disease: UGT1A9 |
MedGen: UGT1A9 (Human Medical Genetics with Condition) | |
ClinVar: UGT1A9 | |
Phenotype | MGI: UGT1A9 (International Mouse Phenotyping Consortium) |
PhenomicDB: UGT1A9 |
Mutations for UGT1A9 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGT1A9 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample |   |   |   |   |   | 1 |   |   | 1 |   | 2 |   |   |   |   |   |   | |||
GAIN (# sample) |   |   |   |   |   | 1 |   |   | 1 |   | 1 |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=70) | (# total SNVs=23) |
(# total SNVs=2) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr2:234581022-234581022 | p.D148N | 5 |
chr2:234581341-234581341 | p.R254Q | 5 |
chr2:234681161-234681161 | p.K517E | 3 |
chr2:234676526-234676526 | p.S340L | 3 |
chr2:234580708-234580708 | p.S43L | 3 |
chr2:234677057-234677057 | p.A423T | 2 |
chr2:234581115-234581115 | p.E179K | 2 |
chr2:234681146-234681146 | p.R512W | 2 |
chr2:234580887-234580887 | p.R103* | 2 |
chr2:234581245-234581245 | p.R222H | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 |   |   | 11 | 2 |   |   |   | 2 |   |   | 7 | 3 | 3 |   |   | 12 | 2 |   | 4 |
# mutation | 1 |   |   | 10 | 2 |   |   |   | 2 |   |   | 8 | 4 | 3 |   |   | 14 | 3 |   | 4 |
nonsynonymous SNV | 1 |   |   | 8 | 2 |   |   |   | 1 |   |   | 6 | 4 | 2 |   |   | 11 | 2 |   | 3 |
synonymous SNV |   |   |   | 2 |   |   |   |   | 1 |   |   | 2 |   | 1 |   |   | 3 | 1 |   | 1 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr2:234581345 | p.D148N | 3 |
chr2:234581022 | p.T255T | 3 |
chr2:234581244 | p.R103Q | 2 |
chr2:234580888 | p.K132I | 2 |
chr2:234580975 | p.R222C | 2 |
chr2:234581152 | p.R254Q | 2 |
chr2:234581341 | p.P191H | 2 |
chr2:234580804 | p.E205K | 1 |
chr2:234581076 | p.Q279H | 1 |
chr2:234581245 | p.S104R | 1 |
Other DBs for Point Mutations |
Copy Number for UGT1A9 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for UGT1A9 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
AKR1C1,ALDH3A1,USB1,C20orf196,DNAJB3,G6PD,GPX2, IQCF2,LOC285629,LSG1,OPA1,RBMXL2,SPTLC3,TBC1D26, UGT1A1,UGT1A3,UGT1A5,UGT1A6,UGT1A9,VCX,VCX3A | C1orf94,CAPNS2,HMOX1,IL36RN,IL36A,KRT4,KRT6A, OR2AG1,OR8D1,RPTN,SNORA19,SNORA21,SNORA54,SPRR2A, SPRR2C,SPRR2E,SPRR3,TMPRSS11A,UGT1A9,UPK1B,VENTXP1 | ||||
AKR1B10,AKR1C1,AKR1C3,MIEN1,DNAJB3,ERBB2,MED24, ORMDL3,OSGIN1,PGAP3,PPP1R1B,PSMD3,RGSL1,SNAR-A2, STARD3,THRA,UGT1A10,UGT1A6,UGT1A7,UGT1A8,UGT1A9 | ABCG2,ACVR2A,AKR1B10,AP1AR,BMF,CDC14A,CTAGE5, FAM73B,FLVCR2,GLS,LPCAT3,MIA2,PDXP,PUS10, RBKS,RHOU,SLC30A1,SNX24,SLC35G1,UGT1A9,USP2 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for UGT1A9 |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Chemistry | BindingDB | O60656; -. |
Chemistry | ChEMBL | CHEMBL1743319; -. |
Organism-specific databases | PharmGKB | PA419; -. |
Organism-specific databases | CTD | 54600; -. |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB04552 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Niflumic Acid | ||
DB04824 | UDP glucuronosyltransferase 1 family, polypeptide A9 | withdrawn | Phenolphthalein | ||
DB00877 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Sirolimus | ||
DB01024 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Mycophenolic acid | ||
DB00252 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Phenytoin | ||
DB00842 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Oxazepam | ||
DB00317 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Gefitinib | ||
DB00864 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Tacrolimus | ||
DB00184 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Nicotine | ||
DB00224 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Indinavir | ||
DB00196 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Fluconazole | ||
DB01026 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Ketoconazole | ||
DB00398 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Sorafenib | ||
DB03496 | UDP glucuronosyltransferase 1 family, polypeptide A9 | experimental; investigational | Flavopiridol | ||
DB00818 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Propofol | ||
DB00688 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Mycophenolate mofetil | ||
DB00762 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Irinotecan | ||
DB00316 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Acetaminophen | ||
DB00355 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Aztreonam | ||
DB00250 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Dapsone | ||
DB00494 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Entacapone | ||
DB00598 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Labetalol | ||
DB00571 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; investigational | Propranolol | ||
DB00323 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved; withdrawn | Tolcapone | ||
DB00695 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Furosemide | ||
DB06697 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Artemether | ||
DB00712 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Flurbiprofen | ||
DB01050 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Ibuprofen | ||
DB01009 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Ketoprofen | ||
DB00451 | UDP glucuronosyltransferase 1 family, polypeptide A9 | approved | Levothyroxine |
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Cross referenced IDs for UGT1A9 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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