Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for CROT
Basic gene info.Gene symbolCROT
Gene namecarnitine O-octanoyltransferase
SynonymsCOT
CytomapUCSC genome browser: 7q21.1
Genomic locationchr7 :86974950-86989425
Type of geneprotein-coding
RefGenesNM_001143935.1,
NM_001243745.1,NM_021151.3,
Ensembl idENSG00000005469
Descriptionperoxisomal carnitine O-octanoyltransferaseperoxisomal carnitine acyltransferase
Modification date20141207
dbXrefs MIM : 606090
HGNC : HGNC
Ensembl : ENSG00000005469
HPRD : 12081
Vega : OTTHUMG00000023653
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CROT
BioGPS: 54677
Gene Expression Atlas: ENSG00000005469
The Human Protein Atlas: ENSG00000005469
PathwayNCI Pathway Interaction Database: CROT
KEGG: CROT
REACTOME: CROT
ConsensusPathDB
Pathway Commons: CROT
MetabolismMetaCyc: CROT
HUMANCyc: CROT
RegulationEnsembl's Regulation: ENSG00000005469
miRBase: chr7 :86,974,950-86,989,425
TargetScan: NM_001143935
cisRED: ENSG00000005469
ContextiHOP: CROT
cancer metabolism search in PubMed: CROT
UCL Cancer Institute: CROT
Assigned class in ccmGDBC

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Phenotypic Information for CROT(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: CROT
Familial Cancer Database: CROT
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_PEROXISOMAL_LIPID_METABOLISM
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: CROT
MedGen: CROT (Human Medical Genetics with Condition)
ClinVar: CROT
PhenotypeMGI: CROT (International Mouse Phenotyping Consortium)
PhenomicDB: CROT

Mutations for CROT
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows CROT related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=5

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=66)
Stat. for Synonymous SNVs
(# total SNVs=13)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=1)

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr7:87006749-87006749p.F321L4
chr7:87011450-87011450p.K375E4
chr7:86990850-86990850p.L129I3
chr7:87022269-87022269p.G535V2
chr7:87011492-87011492p.R389G2
chr7:87011494-87011494p.R389S2
chr7:86990745-86990745p.R94C2
chr7:87011495-87011495p.E390K2
chr7:87022321-87022321p.Q552H2
chr7:87011811-87011811p.T418K2

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=4

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample35 121 112  1252 136 9
# mutation35 111 113  1152 137 10
nonsynonymous SNV33 7  112  1052 137 7
synonymous SNV 2 41   1  1       3
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr7:87011450p.K375E,CROT4
chr7:86990850p.L129F,CROT3
chr7:87022269p.G535V,CROT2
chr7:87005203p.Q552H,CROT2
chr7:87022321p.Q270Q,CROT2
chr7:86998763p.P26S,CROT1
chr7:87021891p.V202F,CROT1
chr7:87006753p.R352T,CROT1
chr7:87011494p.R477C,CROT1
chr7:86998766p.Y35S,CROT1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for CROT in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for CROT

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

ANKRA2,APPL2,AR,SMIM14,CROT,HNMT,INPP4B,
FAM214A,MEGF9,MPV17L,NEDD4,RETSAT,RHOB,RNF103,
SC5D,SEC14L2,SEMA3C,TMEM62,TP53TG1,TRIM6,USP40
ACPP,ALCAM,ARSD,ATG16L1,HEXA-AS1,CROT,FAM174B,
FOXA1,GALNT3,MBOAT2,PTPLAD1,PXMP4,SLC38A1,STYK1,
TFAP2B,TMEM63C,TMEM87B,TRIM36,ZNF613,ZNF626,ZNF649

ANKIB1,TMEM243,TMEM248,CCDC132,COG5,CRCP,CROT,
FAM185A,FAM200A,GALNT11,GATAD1,KRIT1,NAPEPLD,PEX1,
RPS6KA6,SEMA3C,TP53TG1,TRIM4,TYW1,VKORC1L1,ZSCAN25
ACVR2A,AKR1B10,ANO10,AP1AR,BMF,SUGCT,CROT,
ETFDH,FAM73B,FMO4,HADHA,HADHB,KALRN,LPCAT3,
PBLD,RBKS,SEPSECS,SLC27A4,SLC41A2,TMEM82,UGT1A9
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for CROT
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00583carnitine O-octanoyltransferaseapprovedL-Carnitine
DB02648carnitine O-octanoyltransferaseexperimental(3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium
DB03832carnitine O-octanoyltransferaseexperimental3-Carboxy-N,N,N-Trimethyl-2-(Octanoyloxy)Propan-1-Aminium


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Cross referenced IDs for CROT
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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