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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for PPP1CA |
Basic gene info. | Gene symbol | PPP1CA |
Gene name | protein phosphatase 1, catalytic subunit, alpha isozyme | |
Synonyms | PP-1A|PP1A|PP1alpha|PPP1A | |
Cytomap | UCSC genome browser: 11q13 | |
Genomic location | chr11 :67165651-67169376 | |
Type of gene | protein-coding | |
RefGenes | NM_001008709.1, NM_002708.3,NM_206873.1, | |
Ensembl id | ENSG00000172531 | |
Description | protein phosphatase 1, catalytic subunit, alpha isoformserine/threonine protein phosphatase PP1-alpha 1 catalytic subunitserine/threonine-protein phosphatase PP1-alpha catalytic subunit | |
Modification date | 20141222 | |
dbXrefs | MIM : 176875 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172531 | ||
HPRD : 15942 | ||
Vega : OTTHUMG00000167671 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PPP1CA | |
BioGPS: 5499 | ||
Gene Expression Atlas: ENSG00000172531 | ||
The Human Protein Atlas: ENSG00000172531 | ||
Pathway | NCI Pathway Interaction Database: PPP1CA | |
KEGG: PPP1CA | ||
REACTOME: PPP1CA | ||
ConsensusPathDB | ||
Pathway Commons: PPP1CA | ||
Metabolism | MetaCyc: PPP1CA | |
HUMANCyc: PPP1CA | ||
Regulation | Ensembl's Regulation: ENSG00000172531 | |
miRBase: chr11 :67,165,651-67,169,376 | ||
TargetScan: NM_001008709 | ||
cisRED: ENSG00000172531 | ||
Context | iHOP: PPP1CA | |
cancer metabolism search in PubMed: PPP1CA | ||
UCL Cancer Institute: PPP1CA | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for PPP1CA(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: PPP1CA |
Familial Cancer Database: PPP1CA |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: PPP1CA |
MedGen: PPP1CA (Human Medical Genetics with Condition) | |
ClinVar: PPP1CA | |
Phenotype | MGI: PPP1CA (International Mouse Phenotyping Consortium) |
PhenomicDB: PPP1CA |
Mutations for PPP1CA |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PPP1CA related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
BI029138 | RAD9A | 31 | 246 | 11 | 67165768 | 67165982 | PPP1CA | 245 | 357 | 11 | 67168355 | 67168615 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=15) | (# total SNVs=8) |
(# total SNVs=1) | (# total SNVs=0) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr11:67168653-67168653 | p.G25C | 4 |
chr11:67168290-67168290 | p.R96S | 2 |
chr11:67167127-67167127 | p.R143H | 2 |
chr11:67166051-67166051 | p.G316G | 2 |
chr11:67166196-67166196 | p.F293F | 1 |
chr11:67166587-67166587 | p.R191W | 1 |
chr11:67168334-67168334 | p.P82S | 1 |
chr11:67166260-67166260 | p.Y272C | 1 |
chr11:67167056-67167056 | p.E167* | 1 |
chr11:67168340-67168340 | p.G80S | 1 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 1 |   | 4 |   |   |   |   | 1 |   |   | 2 | 1 |   |   |   | 3 | 2 |   | 2 |
# mutation | 4 | 1 |   | 4 |   |   |   |   | 1 |   |   | 2 | 1 |   |   |   | 3 | 2 |   | 2 |
nonsynonymous SNV | 4 |   |   | 2 |   |   |   |   | 1 |   |   | 2 | 1 |   |   |   | 2 | 2 |   | 2 |
synonymous SNV |   | 1 |   | 2 |   |   |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr11:67166318 | p.F249F,PPP1CA | 1 |
chr11:67168577 | p.G32C,PPP1CA | 1 |
chr11:67166321 | p.Y228C,PPP1CA | 1 |
chr11:67168617 | p.S20Y | 1 |
chr11:67166500 | p.V220A,PPP1CA | 1 |
chr11:67168665 | p.D209N,PPP1CA | 1 |
chr11:67166506 | p.E208K,PPP1CA | 1 |
chr11:67168700 | p.D176Y,PPP1CA | 1 |
chr11:67166578 | p.E174K,PPP1CA | 1 |
chr11:67166579 | p.D150N,PPP1CA | 1 |
Other DBs for Point Mutations |
Copy Number for PPP1CA in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for PPP1CA |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ADRBK1,AIP,ANKRD13D,BRMS1,C11orf24,CDK2AP2,CHKA, CORO1B,LOC645332,MRPL21,NDUFS8,NDUFV1,POLD4,PPP1CA, RAD9A,RBM4,RHOD,RPS6KB2,SSH3,TMEM134,UNC93B1 | ARF5,ATP6V0B,COPE,FIBP,HSPBP1,LSM4,LSM7, LYPLA2,MRPL52,MRPS12,OTUB1,POP7,PPP1CA,PPP1R14B, PPP2R1A,PPP4C,PSMG3,RALY,TBCB,TMEM134,TSPAN17 | ||||
BANF1,TMEM258,LAMTOR1,UQCC3,CFL1,COA4,COPE, COX8A,FAU,MRPL11,NUBP2,POLR2G,PPP1CA,PPP4C, RPS6KB2,SDHAF2,PAM16,TIMM8B,TMEM179B,TMEM223,YIF1A | BLOC1S1,CIB1,COX6A1,COX8A,HN1,MAD2L1BP,NOSIP, NT5C,NUDT22,OTUB1,PLEKHJ1,POLD4,PPP1CA,PPP4C, PRSS3,RAB4B,RER1,TAF10,TMSB4XP8,TSG101,WIBG |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for PPP1CA |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB02506 | protein phosphatase 1, catalytic subunit, alpha isozyme | experimental | 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid | ||
DB00171 | protein phosphatase 1, catalytic subunit, alpha isozyme | approved; nutraceutical | Adenosine triphosphate | ||
DB00988 | protein phosphatase 1, catalytic subunit, alpha isozyme | approved | Dopamine |
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Cross referenced IDs for PPP1CA |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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