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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for PPP2R5D |
Basic gene info. | Gene symbol | PPP2R5D |
Gene name | protein phosphatase 2, regulatory subunit B', delta | |
Synonyms | B56D | |
Cytomap | UCSC genome browser: 6p21.1 | |
Genomic location | chr6 :42952329-42980080 | |
Type of gene | protein-coding | |
RefGenes | NM_001270476.1, NM_006245.3,NM_180976.2,NM_180977.2, | |
Ensembl id | ENSG00000112640 | |
Description | PP2A B subunit isoform B'-deltaPP2A B subunit isoform B56-deltaPP2A B subunit isoform PR61-deltaPP2A B subunit isoform R5-deltaPP2A, B subunit, B' delta isoformPP2A, B subunit, B56 delta isoformPP2A, B subunit, PR61 delta isoformPP2A, B subunit, R5 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601646 | |
HGNC : HGNC | ||
Ensembl : ENSG00000112640 | ||
HPRD : 09039 | ||
Vega : OTTHUMG00000014716 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PPP2R5D | |
BioGPS: 5528 | ||
Gene Expression Atlas: ENSG00000112640 | ||
The Human Protein Atlas: ENSG00000112640 | ||
Pathway | NCI Pathway Interaction Database: PPP2R5D | |
KEGG: PPP2R5D | ||
REACTOME: PPP2R5D | ||
ConsensusPathDB | ||
Pathway Commons: PPP2R5D | ||
Metabolism | MetaCyc: PPP2R5D | |
HUMANCyc: PPP2R5D | ||
Regulation | Ensembl's Regulation: ENSG00000112640 | |
miRBase: chr6 :42,952,329-42,980,080 | ||
TargetScan: NM_001270476 | ||
cisRED: ENSG00000112640 | ||
Context | iHOP: PPP2R5D | |
cancer metabolism search in PubMed: PPP2R5D | ||
UCL Cancer Institute: PPP2R5D | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for PPP2R5D(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: PPP2R5D |
Familial Cancer Database: PPP2R5D |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_INTEGRATION_OF_ENERGY_METABOLISM REACTOME_METABOLISM_OF_CARBOHYDRATES REACTOME_GLUCOSE_METABOLISM |
Mutations for PPP2R5D |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
pancreas | PPP2R5D | chr6 | 42968756 | 42968776 | chr6 | 46757961 | 46757981 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PPP2R5D related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=35) | (# total SNVs=15) |
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(# total SNVs=2) | (# total SNVs=1) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr6:42975737-42975737 | p.R264H | 2 |
chr6:42975745-42975745 | p.G267S | 2 |
chr6:42974938-42974938 | p.S176* | 2 |
chr6:42957352-42957352 | p.K13fs*94 | 2 |
chr6:42974675-42974675 | p.L117L | 2 |
chr6:42977143-42977143 | p.I445I | 2 |
chr6:42975942-42975942 | p.F287F | 2 |
chr6:42974777-42974777 | p.E151K | 1 |
chr6:42977074-42977074 | p.A422A | 1 |
chr6:42978631-42978631 | p.R523* | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 3 | 1 | 6 | 1 |   | 3 |   | 1 |   |   | 5 |   | 1 |   | 1 | 1 | 6 |   | 11 |
# mutation | 2 | 3 | 1 | 6 | 1 |   | 3 |   | 1 |   |   | 6 |   | 1 |   | 1 | 1 | 6 |   | 12 |
nonsynonymous SNV | 1 | 2 |   | 4 |   |   | 3 |   |   |   |   | 5 |   | 1 |   |   | 1 | 3 |   | 8 |
synonymous SNV | 1 | 1 | 1 | 2 | 1 |   |   |   | 1 |   |   | 1 |   |   |   | 1 |   | 3 |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr6:42975737 | p.R158H,PPP2R5D | 3 |
chr6:42974675 | p.L11L,PPP2R5D | 2 |
chr6:42975175 | p.T490T,PPP2R5D | 1 |
chr6:42976451 | p.E45D,PPP2R5D | 1 |
chr6:42974730 | p.I202I,PPP2R5D | 1 |
chr6:42978669 | p.R54C,PPP2R5D | 1 |
chr6:42975223 | p.R219S,PPP2R5D | 1 |
chr6:42976473 | p.D55N,PPP2R5D | 1 |
chr6:42974732 | p.Q243Q,PPP2R5D | 1 |
chr6:42978683 | p.R75Q,PPP2R5D | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for PPP2R5D |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AARS2,ABCC10,RRP36,CDC5L,CUL7,GTPBP2,HSP90AB1, KLHDC3,MEA1,MED20,MRPS10,MRPS18A,NFYA,POLH, POLR1C,PPP2R5D,SLC29A1,SLC35B2,TJAP1,XPO5,ZNF318 | AP2A1,ATG9A,APOPT1,NATD1,C21orf33,DLST,FZD9, GPI,HADHA,HDLBP,PACS2,GATB,PPP2R5D,PRKACA, PSMD2,SAMM50,SLC25A23,SLC6A8,ST3GAL3,VPS4A,WBSCR16 | ||||
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AARS2,BYSL,RRP36,ZC2HC1B,CCND3,CDCA3,CLDN25, F11,KLHDC3,MAD2L1BP,MEA1,MED20,MRPL2,PPP2R5D, RHAG,SRF,TAF8,TJAP1,TOMM6,XPO5,ZNF318 | ABHD6,ANPEP,ADIRF,GBA3,GCNT4,GNB1,SLC52A1, HEBP1,HOXC11,HOXC6,HOXC8,ING2,LOC148709,MARC2, MSRA,PPP2R5D,PTGR1,SPAM1,SUSD2,AGMO,TTBK1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for PPP2R5D |
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DB Category | DB Name | DB's ID and Url link |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00675 | protein phosphatase 2, regulatory subunit B', delta | approved | Tamoxifen | ![]() | ![]() |
DB01394 | protein phosphatase 2, regulatory subunit B', delta | approved | Colchicine | ![]() | ![]() |
DB00864 | protein phosphatase 2, regulatory subunit B', delta | approved; investigational | Tacrolimus | ![]() | ![]() |
DB00877 | protein phosphatase 2, regulatory subunit B', delta | approved; investigational | Sirolimus | ![]() | ![]() |
DB00131 | protein phosphatase 2, regulatory subunit B', delta | approved; nutraceutical | Adenosine monophosphate | ![]() | ![]() |
DB00171 | protein phosphatase 2, regulatory subunit B', delta | approved; nutraceutical | Adenosine triphosphate | ![]() | ![]() |
DB00988 | protein phosphatase 2, regulatory subunit B', delta | approved | Dopamine | ![]() | ![]() |
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Cross referenced IDs for PPP2R5D |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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