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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for ETNK1 |
Basic gene info. | Gene symbol | ETNK1 |
Gene name | ethanolamine kinase 1 | |
Synonyms | EKI|EKI 1|EKI1|Nbla10396 | |
Cytomap | UCSC genome browser: 12p12.1 | |
Genomic location | chr12 :22778075-22797349 | |
Type of gene | protein-coding | |
RefGenes | NM_001039481.1, NM_018638.4, | |
Ensembl id | ENSG00000139163 | |
Description | putative protein product of Nbla10396 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609858 | |
HGNC : HGNC | ||
Ensembl : ENSG00000139163 | ||
HPRD : 09934 | ||
Vega : OTTHUMG00000169008 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ETNK1 | |
BioGPS: 55500 | ||
Gene Expression Atlas: ENSG00000139163 | ||
The Human Protein Atlas: ENSG00000139163 | ||
Pathway | NCI Pathway Interaction Database: ETNK1 | |
KEGG: ETNK1 | ||
REACTOME: ETNK1 | ||
ConsensusPathDB | ||
Pathway Commons: ETNK1 | ||
Metabolism | MetaCyc: ETNK1 | |
HUMANCyc: ETNK1 | ||
Regulation | Ensembl's Regulation: ENSG00000139163 | |
miRBase: chr12 :22,778,075-22,797,349 | ||
TargetScan: NM_001039481 | ||
cisRED: ENSG00000139163 | ||
Context | iHOP: ETNK1 | |
cancer metabolism search in PubMed: ETNK1 | ||
UCL Cancer Institute: ETNK1 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for ETNK1(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: ETNK1 |
Familial Cancer Database: ETNK1 |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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KEGG_GLYCEROPHOSPHOLIPID_METABOLISM REACTOME_PHOSPHOLIPID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: ETNK1 |
MedGen: ETNK1 (Human Medical Genetics with Condition) | |
ClinVar: ETNK1 | |
Phenotype | MGI: ETNK1 (International Mouse Phenotyping Consortium) |
PhenomicDB: ETNK1 |
Mutations for ETNK1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows ETNK1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CB306777 | ETNK1 | 18 | 281 | 12 | 22837943 | 22838206 | ETNK1 | 275 | 436 | 12 | 22837424 | 22837910 | |
BQ637998 | ETNK1 | 1 | 349 | 12 | 22843240 | 22843588 | ETNK1 | 342 | 623 | 12 | 22842331 | 22842612 | |
BE061136 | ENPP2 | 5 | 80 | 8 | 120609938 | 120610015 | ETNK1 | 73 | 599 | 12 | 22787799 | 22788325 | |
CV420024 | RBBP6 | 3 | 75 | 16 | 24555953 | 24556026 | ETNK1 | 71 | 520 | 12 | 22784348 | 22784797 |
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Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 2 |   | 1 |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   | |||
GAIN (# sample) | 2 |   | 1 |   |   |   |   |   |   |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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Stat. for Non-Synonymous SNVs (# total SNVs=34) | (# total SNVs=14) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr12:22826447-22826447 | p.V355V | 2 |
chr12:22796734-22796734 | p.C154Y | 2 |
chr12:22812085-22812085 | p.K274T | 2 |
chr12:22796743-22796743 | p.G157V | 2 |
chr12:22778163-22778163 | p.L22L | 2 |
chr12:22796809-22796809 | p.R179Q | 2 |
chr12:22778446-22778446 | p.R117G | 2 |
chr12:22812050-22812050 | p.L262L | 2 |
chr12:22837881-22837881 | p.P451L | 2 |
chr12:22796699-22796699 | p.L142L | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 3 |   | 5 | 1 |   |   |   | 3 |   |   | 3 | 3 | 1 |   |   | 3 | 2 |   | 9 |
# mutation | 1 | 3 |   | 4 | 1 |   |   |   | 3 |   |   | 3 | 4 | 1 |   |   | 4 | 2 |   | 10 |
nonsynonymous SNV | 1 | 3 |   | 2 |   |   |   |   | 2 |   |   | 1 | 3 | 1 |   |   | 3 | 1 |   | 8 |
synonymous SNV |   |   |   | 2 | 1 |   |   |   | 1 |   |   | 2 | 1 |   |   |   | 1 | 1 |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr12:22796773 | p.R179Q,ETNK1 | 2 |
chr12:22796809 | p.K274T | 2 |
chr12:22812085 | p.R167K,ETNK1 | 2 |
chr12:22811990 | p.E181E,ETNK1 | 1 |
chr12:22826547 | p.L300L | 1 |
chr12:22796805 | p.L198P,ETNK1 | 1 |
chr12:22812020 | p.I328I | 1 |
chr12:22837848 | p.I211T,ETNK1 | 1 |
chr12:22812025 | p.V355V | 1 |
chr12:22778110 | p.D217N,ETNK1 | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for ETNK1 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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AEBP2,AMN1,METTL20,CASC1,CCDC91,CMAS,ETNK1, FGD4,FGFR1OP2,GOLT1B,IPO8,C2CD5,KLHL42,KRAS, LYRM5,MED21,MIB1,MRPS35,PYROXD1,RECQL,TM7SF3 | ANGEL2,CD2AP,CREBZF,DCAF17,ETNK1,FAM122B,FAM76B, FAM91A1,G2E3,CEP44,MOB1B,PAN3,PPIP5K2,PTBP3, SCAMP1,SRSF10,SPIN4,TIA1,TRIM33,ZMYM6,ZNF529 |
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ACTR6,AEBP2,ARL1,C12orf29,ETNK1,FAM103A1,GMNN, GOLT1B,MRPL42,NECAP1,PYROXD1,RAP1B,SEC11C,TBC1D15, TDG,TMED2,TMPO,TWF1,VEZT,YEATS4,ZFAND6 | ABHD5,CA2,CSTB,MICU2,ETFDH,ETNK1,FAM45A, FDX1,GDPD3,GHITM,C2CD5,LACTB,LOC25845,ME2, NRG4,OASL,PITX2,SLC20A1,TEKT5,UGDH,UGT1A10 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for ETNK1 |
There's no related Drug. |
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Cross referenced IDs for ETNK1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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