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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for UGGT2 |
Basic gene info. | Gene symbol | UGGT2 |
Gene name | UDP-glucose glycoprotein glucosyltransferase 2 | |
Synonyms | HUGT2|UGCGL2|UGT2 | |
Cytomap | UCSC genome browser: 13q32.1 | |
Genomic location | chr13 :96453835-96705736 | |
Type of gene | protein-coding | |
RefGenes | NM_020121.3, | |
Ensembl id | ENSG00000102595 | |
Description | UDP--Glc:glycoprotein glucosyltransferase 2UDP-Glc:glycoprotein glucosyltransferase 2UDP-glucose ceramide glucosyltransferase-like 1UDP-glucose ceramide glucosyltransferase-like 2UDP-glucose:glycoprotein glucosyltransferase 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605898 | |
HGNC : HGNC | ||
Ensembl : ENSG00000102595 | ||
HPRD : 12065 | ||
Vega : OTTHUMG00000017230 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_UGGT2 | |
BioGPS: 55757 | ||
Gene Expression Atlas: ENSG00000102595 | ||
The Human Protein Atlas: ENSG00000102595 | ||
Pathway | NCI Pathway Interaction Database: UGGT2 | |
KEGG: UGGT2 | ||
REACTOME: UGGT2 | ||
ConsensusPathDB | ||
Pathway Commons: UGGT2 | ||
Metabolism | MetaCyc: UGGT2 | |
HUMANCyc: UGGT2 | ||
Regulation | Ensembl's Regulation: ENSG00000102595 | |
miRBase: chr13 :96,453,835-96,705,736 | ||
TargetScan: NM_020121 | ||
cisRED: ENSG00000102595 | ||
Context | iHOP: UGGT2 | |
cancer metabolism search in PubMed: UGGT2 | ||
UCL Cancer Institute: UGGT2 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for UGGT2(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: UGGT2 |
Familial Cancer Database: UGGT2 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_METABOLISM_OF_PROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: UGGT2 |
MedGen: UGGT2 (Human Medical Genetics with Condition) | |
ClinVar: UGGT2 | |
Phenotype | MGI: UGGT2 (International Mouse Phenotyping Consortium) |
PhenomicDB: UGGT2 |
Mutations for UGGT2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | UGGT2 | chr13 | 96623745 | 96623765 | UGGT2 | chr13 | 96623847 | 96623867 |
ovary | UGGT2 | chr13 | 96628289 | 96628309 | UGGT2 | chr13 | 96628423 | 96628443 |
ovary | UGGT2 | chr13 | 96633585 | 96633785 | chr10 | 88513311 | 88513511 | |
pancreas | UGGT2 | chr13 | 96530632 | 96530652 | FARP1 | chr13 | 98987858 | 98987878 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows UGGT2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
CA335867 | UGGT2 | 1 | 233 | 13 | 96622366 | 96624915 | UGGT2 | 233 | 526 | 13 | 96638665 | 96651562 | |
CV414163 | UGGT2 | 18 | 431 | 13 | 96685111 | 96685524 | SLC26A2 | 428 | 628 | 5 | 149362988 | 149363188 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 3 |   |   |   |   |   |   |   | 1 |   | 1 |   |   |   |   |   |   | |||
GAIN (# sample) | 3 |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=120) | (# total SNVs=21) |
(# total SNVs=2) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr13:96506702-96506702 | p.R1346* | 4 |
chr13:96506646-96506646 | p.R1364R | 3 |
chr13:96506664-96506664 | p.T1358T | 3 |
chr13:96508411-96508411 | p.? | 3 |
chr13:96511855-96511855 | p.P1272L | 3 |
chr13:96555182-96555182 | p.L810F | 2 |
chr13:96506627-96506627 | p.R1371C | 2 |
chr13:96530054-96530054 | p.Q1095Q | 2 |
chr13:96508474-96508474 | p.L1316I | 2 |
chr13:96599320-96599320 | p.I550V | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 | 6 |   | 28 | 3 |   | 3 |   | 3 |   |   | 11 | 8 | 2 | 1 | 1 | 13 | 7 | 1 | 13 |
# mutation | 2 | 6 |   | 30 | 3 |   | 3 |   | 3 |   |   | 13 | 8 | 2 | 1 | 1 | 14 | 7 | 1 | 15 |
nonsynonymous SNV | 2 | 4 |   | 26 | 2 |   | 3 |   | 3 |   |   | 10 | 7 | 2 | 1 | 1 | 11 | 4 | 1 | 12 |
synonymous SNV |   | 2 |   | 5 | 1 |   |   |   |   |   |   | 3 | 1 |   |   |   | 3 | 3 |   | 3 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr13:96579527 | p.R1371S | 2 |
chr13:96540199 | p.L743F | 2 |
chr13:96599352 | p.K995N | 2 |
chr13:96601605 | p.R539Q | 2 |
chr13:96578002 | p.R681S | 2 |
chr13:96506627 | p.R480H | 2 |
chr13:96665587 | p.L806F | 1 |
chr13:96529989 | p.S597C | 1 |
chr13:96592328 | p.N338N | 1 |
chr13:96675927 | p.W1373R | 1 |
Other DBs for Point Mutations |
Copy Number for UGGT2 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for UGGT2 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
ABHD13,COG6,CUL4A,DIS3,DNAJC3,DOCK9,GPR180, IPO5,GPALPP1,LIG4,MTMR6,NDFIP2,PIBF1,RBM26, TGDS,TM9SF2,TMTC4,TPP2,TUBGCP3,UGGT2,CHAMP1 | AFF4,AQR,ATR,FAM208A,CTDSPL2,GCC2,CFAP97, KIAA1468,MON2,PDS5A,PPIP5K2,RASA1,RUFY2,SLC35A3, SMARCAD1,TAF2,THOC2,UBA6,UGGT2,WRN,ZNF800 |
ALG5,BIVM,SPRYD7,CDC16,COG6,CUL4A,DIS3, IPO5,GPALPP1,KPNA3,MED4,N4BP2L2,PCID2,PIBF1, RNASEH2B,RNF219,TGDS,TM9SF2,UBAC2,UFM1,UGGT2 | AHI1,ARL13B,ASPH,CUL5,DNAJC27,GPR180,HIAT1, INTU,NAA16,NAB1,PIAS2,PMS1,POLK,PRDM5, RUFY2,SMAD5,TMX3,TRAPPC6B,UGGT2,ZBTB41,ZNF354B |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for UGGT2 |
There's no related Drug. |
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Cross referenced IDs for UGGT2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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