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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for PRKD1 |
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Phenotypic Information for PRKD1(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: PRKD1 |
Familial Cancer Database: PRKD1 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
REACTOME_PHOSPHOLIPID_METABOLISM REACTOME_SPHINGOLIPID_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | 605435; gene. |
Orphanet | |
Disease | KEGG Disease: PRKD1 |
MedGen: PRKD1 (Human Medical Genetics with Condition) | |
ClinVar: PRKD1 | |
Phenotype | MGI: PRKD1 (International Mouse Phenotyping Consortium) |
PhenomicDB: PRKD1 |
Mutations for PRKD1 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
- Statistics for Tissue and Mutation type | Top |
- For Inter-chromosomal Variations |
* Inter-chromosomal variantions includes 'interchromosomal amplicon to amplicon', 'interchromosomal amplicon to non-amplified dna', 'interchromosomal insertion', 'Interchromosomal unknown type'. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | PRKD1 | chr14 | 30262836 | 30262856 | PRKD1 | chr14 | 30257188 | 30257208 |
ovary | PRKD1 | chr14 | 30370955 | 30370975 | PRKD1 | chr14 | 30371276 | 30371296 |
pancreas | PRKD1 | chr14 | 30313270 | 30313470 | PRKD1 | chr14 | 30314294 | 30314494 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PRKD1 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AW580521 | PRKD1 | 37 | 62 | 14 | 30216674 | 30216702 | WAC | 59 | 175 | 10 | 28897227 | 28897605 |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
Mutation type/ Tissue ID | brca | cns | cerv | endome | haematopo | kidn | Lintest | liver | lung | ns | ovary | pancre | prost | skin | stoma | thyro | urina | |||
Total # sample | 4 |   |   |   |   |   |   |   | 9 |   | 1 |   |   |   | 1 | 1 |   | |||
GAIN (# sample) | 4 |   |   |   |   |   |   |   | 8 |   | 1 |   |   |   | 1 | 1 |   | |||
LOSS (# sample) |   |   |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract) |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=138) | (# total SNVs=37) |
(# total SNVs=2) | (# total SNVs=2) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:30068249-30068249 | p.A717V | 4 |
chr14:30068938-30068938 | p.G664V | 3 |
chr14:30194796-30194796 | p.V117M | 3 |
chr14:30135363-30135363 | p.H152R | 3 |
chr14:30046613-30046613 | p.E857G | 3 |
chr14:30132965-30132965 | p.V212V | 3 |
chr14:30046614-30046614 | p.E857* | 3 |
chr14:30068238-30068238 | p.P721S | 3 |
chr14:30066795-30066795 | p.G779D | 3 |
chr14:30194878-30194878 | p.F89L | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 4 | 1 |   | 30 | 1 |   | 16 |   | 4 |   | 1 | 19 | 13 | 6 |   |   | 5 | 17 | 3 | 14 |
# mutation | 4 | 1 |   | 32 | 1 |   | 16 |   | 4 |   | 1 | 21 | 14 | 6 |   |   | 5 | 19 | 3 | 15 |
nonsynonymous SNV | 2 | 1 |   | 24 | 1 |   | 10 |   | 4 |   |   | 17 | 11 | 3 |   |   | 3 | 13 | 3 | 9 |
synonymous SNV | 2 |   |   | 9 |   |   | 6 |   |   |   | 1 | 4 | 3 | 3 |   |   | 2 | 6 |   | 6 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:30046613 | p.E857G | 3 |
chr14:30100144 | p.A717V | 2 |
chr14:30068938 | p.T458I | 2 |
chr14:30068249 | p.D841D | 2 |
chr14:30105555 | p.G254A | 2 |
chr14:30066890 | p.N377N | 2 |
chr14:30102094 | p.P747P | 2 |
chr14:30108046 | p.G664V | 2 |
chr14:30046660 | p.F492F | 2 |
chr14:30095738 | p.L175H | 1 |
Other DBs for Point Mutations |
Copy Number for PRKD1 in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for PRKD1 |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
C14orf37,CACNG5,CBLN1,CHSY3,CRYBA2,DCN,DPYSL3, FEV,GLT8D2,INSRR,KIAA1614,MRVI1,MSRB3,NAP1L3, PRKD1,RECK,SAMD14,ST8SIA3,TRPM3,TSHZ3,WNT16 | BBS7,BNIP2,C4orf3,CLDND1,CLIC4,DPYD,FBXO33, FBXO8,GNG12,KDSR,LMBRD1,MBNL2,MMGT1,PLEKHA3, PPP2CB,PRKD1,PTPN12,RAB28,TMEM47,TRPC1,VPS26A |
AMOTL1,ARHGEF17,BNC2,CALD1,CYS1,DPYSL3,DZIP1, FAM110B,FBXL7,FERMT2,JAM3,KANK2,LAYN,MAP1A, MPDZ,MRVI1,MSRB3,PRKD1,SGCD,STON1,ZEB1 | CACNA2D1,CLIP4,COPZ2,DENND5A,EHBP1,FIBIN,GUCY1A3, KLHL5,LOC344595,PBX3,PHLDB2,PRDM8,PRKD1,RIMKLB, SCN7A,SULF1,TCEAL3,TCEAL4,WWC2,ZCCHC24,ZEB1 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for PRKD1 |
There's no related Drug. |
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Cross referenced IDs for PRKD1 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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