Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for MAPK11
Basic gene info.Gene symbolMAPK11
Gene namemitogen-activated protein kinase 11
SynonymsP38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta
CytomapUCSC genome browser: 22q13.33
Genomic locationchr22 :50702141-50708779
Type of geneprotein-coding
RefGenesNM_002751.6,
NR_110887.1,
Ensembl idENSG00000185386
DescriptionMAP kinase 11MAP kinase p38 betamitogen-activated protein kinase p38 betamitogen-activated protein kinase p38-2stress-activated protein kinase-2stress-activated protein kinase-2b
Modification date20141222
dbXrefs MIM : 602898
HGNC : HGNC
Ensembl : ENSG00000185386
HPRD : 04208
Vega : OTTHUMG00000150226
ProteinUniProt: Q15759
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAPK11
BioGPS: 5600
Gene Expression Atlas: ENSG00000185386
The Human Protein Atlas: ENSG00000185386
PathwayNCI Pathway Interaction Database: MAPK11
KEGG: MAPK11
REACTOME: MAPK11
ConsensusPathDB
Pathway Commons: MAPK11
MetabolismMetaCyc: MAPK11
HUMANCyc: MAPK11
RegulationEnsembl's Regulation: ENSG00000185386
miRBase: chr22 :50,702,141-50,708,779
TargetScan: NM_002751
cisRED: ENSG00000185386
ContextiHOP: MAPK11
cancer metabolism search in PubMed: MAPK11
UCL Cancer Institute: MAPK11
Assigned class in ccmGDBB - This gene belongs to cancer gene.

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Phenotypic Information for MAPK11(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: MAPK11
Familial Cancer Database: MAPK11
* This gene is included in those cancer gene databases.

.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
REACTOME_METABOLISM_OF_MRNA
REACTOME_METABOLISM_OF_RNA

check002.gifOthers
OMIM 602898; gene.
602898; gene.
Orphanet
DiseaseKEGG Disease: MAPK11
MedGen: MAPK11 (Human Medical Genetics with Condition)
ClinVar: MAPK11
PhenotypeMGI: MAPK11 (International Mouse Phenotyping Consortium)
PhenomicDB: MAPK11

Mutations for MAPK11
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MAPK11 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=2

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=19)
Stat. for Synonymous SNVs
(# total SNVs=5)
Stat. for Deletions
(# total SNVs=1)
Stat. for Insertions
(# total SNVs=0)
There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr22:50705712-50705712p.I141L2
chr22:50703850-50703850p.H305H2
chr22:50704661-50704661p.S252S1
chr22:50705436-50705436p.M179I1
chr22:50708690-50708690p.Q11fs*31
chr22:50704662-50704662p.S252*1
chr22:50705455-50705455p.R173L1
chr22:50704717-50704717p.R234C1
chr22:50705474-50705474p.L167M1
chr22:50704973-50704973p.S226S1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample2 1 1 3    11   21 4
# mutation2 1 1 3    11   21 5
nonsynonymous SNV2 1 1 2    11   11 3
synonymous SNV      1         1  2
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr22:50703900p.L289V2
chr22:50704989p.R173L1
chr22:50705394p.L167M1
chr22:50705416p.R149W1
chr22:50705436p.E125K1
chr22:50705455p.I116N1
chr22:50703752p.V52M1
chr22:50705474p.K338R1
chr22:50703786p.V327I1
chr22:50705688p.H305H1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for MAPK11 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for MAPK11

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

CCM2,CLDN5,COX4I2,EXOC3L1,ABHD17A,GLYCTK,GRASP,
HDAC10,KANK3,LMF2,LYL1,MAPK11,MAPK12,PLAC9,
INAFM1,RNF166,RPS19BP1,SELO,TNFRSF4,TWF2,VAMP5
AGPAT2,ASS1,C20orf27,CAMK1,CKB,EFNB1,FCN3,
FPGS,GCHFR,KANK3,MAPK11,MPST,PC,PHLDA3,
PMM1,POLR2E,PQLC1,SLC25A1,SLC2A4RG,TMEM120A,UBTD1

ADARB1,CCM2L,CCDC88A,EVL,FAM167B,NXPE3,GIMAP1,
GIMAP4,HAPLN3,HSPA12B,KANK3,LYL1,MAPK11,NFATC1,
PEAR1,PIK3CD,SH2D3C,TSPAN4,VEGFC,ZBTB46,ZNF467
ARHGEF15,C1R,C1S,CDH5,CLU,DCLK1,DOC2B,
GJA4,GPR173,HSPA12B,MAPK11,MMP2,PCDH17,PECAM1,
PRRX1,ROBO4,SERPING1,THSD1,THY1,TIE1,TIMP1
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for MAPK11
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB Q15759; -.
ChemistryChEMBL CHEMBL3961; -.
ChemistryGuidetoPHARMACOLOGY 1500; -.
ChemistryBindingDB Q15759; -.
ChemistryChEMBL CHEMBL3961; -.
ChemistryGuidetoPHARMACOLOGY 1500; -.
Organism-specific databasesPharmGKB PA30618; -.
Organism-specific databasesPharmGKB PA30618; -.
Organism-specific databasesCTD 5600; -.
Organism-specific databasesCTD 5600; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB01234mitogen-activated protein kinase 11approved; investigationalDexamethasone
DB00398mitogen-activated protein kinase 11approved; investigationalSorafenib
DB00435mitogen-activated protein kinase 11approvedNitric Oxide
DB00125mitogen-activated protein kinase 11approved; nutraceuticalL-Arginine


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Cross referenced IDs for MAPK11
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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