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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for MAPK11 |
Basic gene info. | Gene symbol | MAPK11 |
Gene name | mitogen-activated protein kinase 11 | |
Synonyms | P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta | |
Cytomap | UCSC genome browser: 22q13.33 | |
Genomic location | chr22 :50702141-50708779 | |
Type of gene | protein-coding | |
RefGenes | NM_002751.6, NR_110887.1, | |
Ensembl id | ENSG00000185386 | |
Description | MAP kinase 11MAP kinase p38 betamitogen-activated protein kinase p38 betamitogen-activated protein kinase p38-2stress-activated protein kinase-2stress-activated protein kinase-2b | |
Modification date | 20141222 | |
dbXrefs | MIM : 602898 | |
HGNC : HGNC | ||
Ensembl : ENSG00000185386 | ||
HPRD : 04208 | ||
Vega : OTTHUMG00000150226 | ||
Protein | UniProt: Q15759 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MAPK11 | |
BioGPS: 5600 | ||
Gene Expression Atlas: ENSG00000185386 | ||
The Human Protein Atlas: ENSG00000185386 | ||
Pathway | NCI Pathway Interaction Database: MAPK11 | |
KEGG: MAPK11 | ||
REACTOME: MAPK11 | ||
ConsensusPathDB | ||
Pathway Commons: MAPK11 | ||
Metabolism | MetaCyc: MAPK11 | |
HUMANCyc: MAPK11 | ||
Regulation | Ensembl's Regulation: ENSG00000185386 | |
miRBase: chr22 :50,702,141-50,708,779 | ||
TargetScan: NM_002751 | ||
cisRED: ENSG00000185386 | ||
Context | iHOP: MAPK11 | |
cancer metabolism search in PubMed: MAPK11 | ||
UCL Cancer Institute: MAPK11 | ||
Assigned class in ccmGDB | B - This gene belongs to cancer gene. |
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Phenotypic Information for MAPK11(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: MAPK11 |
Familial Cancer Database: MAPK11 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
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OMIM | 602898; gene. 602898; gene. |
Orphanet | |
Disease | KEGG Disease: MAPK11 |
MedGen: MAPK11 (Human Medical Genetics with Condition) | |
ClinVar: MAPK11 | |
Phenotype | MGI: MAPK11 (International Mouse Phenotyping Consortium) |
PhenomicDB: MAPK11 |
Mutations for MAPK11 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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There's no structural variation information in COSMIC data for this gene. |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows MAPK11 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=19) | (# total SNVs=5) |
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(# total SNVs=1) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr22:50703850-50703850 | p.H305H | 2 |
chr22:50705712-50705712 | p.I141L | 2 |
chr22:50705861-50705861 | p.C119Y | 1 |
chr22:50705394-50705394 | p.I193I | 1 |
chr22:50706030-50706030 | p.T91T | 1 |
chr22:50703887-50703887 | p.S293I | 1 |
chr22:50705416-50705416 | p.R186H | 1 |
chr22:50706301-50706301 | p.A65V | 1 |
chr22:50704057-50704057 | p.M265I | 1 |
chr22:50705433-50705433 | p.T180T | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 2 |   | 1 |   | 1 |   | 3 |   |   |   |   | 1 | 1 |   |   |   | 2 | 1 |   | 4 |
# mutation | 2 |   | 1 |   | 1 |   | 3 |   |   |   |   | 1 | 1 |   |   |   | 2 | 1 |   | 5 |
nonsynonymous SNV | 2 |   | 1 |   | 1 |   | 2 |   |   |   |   | 1 | 1 |   |   |   | 1 | 1 |   | 3 |
synonymous SNV |   |   |   |   |   |   | 1 |   |   |   |   |   |   |   |   |   | 1 |   |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr22:50703900 | p.L289V | 2 |
chr22:50705870 | p.R234C | 1 |
chr22:50704717 | p.S226S | 1 |
chr22:50706341 | p.A221V | 1 |
chr22:50704973 | p.I193I | 1 |
chr22:50704989 | p.R186L | 1 |
chr22:50705394 | p.M179I | 1 |
chr22:50705416 | p.R173L | 1 |
chr22:50705436 | p.L167M | 1 |
chr22:50705455 | p.R149W | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for MAPK11 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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CCM2,CLDN5,COX4I2,EXOC3L1,ABHD17A,GLYCTK,GRASP, HDAC10,KANK3,LMF2,LYL1,MAPK11,MAPK12,PLAC9, INAFM1,RNF166,RPS19BP1,SELO,TNFRSF4,TWF2,VAMP5 | AGPAT2,ASS1,C20orf27,CAMK1,CKB,EFNB1,FCN3, FPGS,GCHFR,KANK3,MAPK11,MPST,PC,PHLDA3, PMM1,POLR2E,PQLC1,SLC25A1,SLC2A4RG,TMEM120A,UBTD1 | ||||
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ADARB1,CCM2L,CCDC88A,EVL,FAM167B,NXPE3,GIMAP1, GIMAP4,HAPLN3,HSPA12B,KANK3,LYL1,MAPK11,NFATC1, PEAR1,PIK3CD,SH2D3C,TSPAN4,VEGFC,ZBTB46,ZNF467 | ARHGEF15,C1R,C1S,CDH5,CLU,DCLK1,DOC2B, GJA4,GPR173,HSPA12B,MAPK11,MMP2,PCDH17,PECAM1, PRRX1,ROBO4,SERPING1,THSD1,THY1,TIE1,TIMP1 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for MAPK11 |
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DB Category | DB Name | DB's ID and Url link |
Chemistry | BindingDB | Q15759; -. |
Chemistry | ChEMBL | CHEMBL3961; -. |
Chemistry | GuidetoPHARMACOLOGY | 1500; -. |
Chemistry | BindingDB | Q15759; -. |
Chemistry | ChEMBL | CHEMBL3961; -. |
Chemistry | GuidetoPHARMACOLOGY | 1500; -. |
Organism-specific databases | PharmGKB | PA30618; -. |
Organism-specific databases | PharmGKB | PA30618; -. |
Organism-specific databases | CTD | 5600; -. |
Organism-specific databases | CTD | 5600; -. |
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* Gene Centered Interaction Network. |
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* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB01234 | mitogen-activated protein kinase 11 | approved; investigational | Dexamethasone | ![]() | ![]() |
DB00398 | mitogen-activated protein kinase 11 | approved; investigational | Sorafenib | ![]() | ![]() |
DB00435 | mitogen-activated protein kinase 11 | approved | Nitric Oxide | ![]() | ![]() |
DB00125 | mitogen-activated protein kinase 11 | approved; nutraceutical | L-Arginine | ![]() | ![]() |
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Cross referenced IDs for MAPK11 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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