Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

Home

Search

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for BAAT
Basic gene info.Gene symbolBAAT
Gene namebile acid CoA:amino acid N-acyltransferase
SynonymsBACAT|BAT
CytomapUCSC genome browser: 9q22.3
Genomic locationchr9 :104122698-104145801
Type of geneprotein-coding
RefGenesNM_001127610.1,
NM_001701.3,
Ensembl idENSG00000136881
Descriptionbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid-CoA:amino acid N-acyltransferaselong-chain fatty-acyl-CoA hydrolase
Modification date20141207
dbXrefs MIM : 602938
HGNC : HGNC
Ensembl : ENSG00000136881
HPRD : 08376
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_BAAT
BioGPS: 570
Gene Expression Atlas: ENSG00000136881
The Human Protein Atlas: ENSG00000136881
PathwayNCI Pathway Interaction Database: BAAT
KEGG: BAAT
REACTOME: BAAT
ConsensusPathDB
Pathway Commons: BAAT
MetabolismMetaCyc: BAAT
HUMANCyc: BAAT
RegulationEnsembl's Regulation: ENSG00000136881
miRBase: chr9 :104,122,698-104,145,801
TargetScan: NM_001127610
cisRED: ENSG00000136881
ContextiHOP: BAAT
cancer metabolism search in PubMed: BAAT
UCL Cancer Institute: BAAT
Assigned class in ccmGDBC

Top
Phenotypic Information for BAAT(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: BAAT
Familial Cancer Database: BAAT
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS

check002.gifOthers
OMIM
Orphanet
DiseaseKEGG Disease: BAAT
MedGen: BAAT (Human Medical Genetics with Condition)
ClinVar: BAAT
PhenotypeMGI: BAAT (International Mouse Phenotyping Consortium)
PhenomicDB: BAAT

Mutations for BAAT
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram
There's no structural variation information in COSMIC data for this gene.

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows BAAT related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

Top
check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
There's no copy number variation information in COSMIC data for this gene.

Top
check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=3

Top
check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=42)
Stat. for Synonymous SNVs
(# total SNVs=14)
Stat. for Deletions
(# total SNVs=2)
Stat. for Insertions
(# total SNVs=1)

Top
check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr9:104124952-104124952p.Q339K3
chr9:104125001-104125001p.F322F3
chr9:104125007-104125007p.F320F3
chr9:104130542-104130542p.R177W3
chr9:104125077-104125077p.R297H2
chr9:104133605-104133605p.Q28E2
chr9:104133628-104133628p.R20Q2
chr9:104133503-104133503p.H62Y2
chr9:104133260-104133260p.R143*2
chr9:104124751-104124751p.L406F2

Top
check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample12 3  2 211113   154 10
# mutation12 3  2 211113   145 11
nonsynonymous SNV 1 2  2 21193   103 7
synonymous SNV11 1       2    42 4
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

Top
check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr9:104130542p.F322F,BAAT3
chr9:104125001p.F320F,BAAT3
chr9:104125007p.R177W,BAAT3
chr9:104124832p.R297H,BAAT1
chr9:104133522p.G145D,BAAT1
chr9:104124985p.T376M,BAAT1
chr9:104125209p.Y270Y,BAAT1
chr9:104133228p.R143L,BAAT1
chr9:104124839p.P367S,BAAT1
chr9:104133542p.P263S,BAAT1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for BAAT in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

Top
Gene Expression for BAAT

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
Top
check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


Top
Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

APCS,APOA2,APOA4,APOC3,ARG1,BAAT,C8A,
C9,CREB3L3,CRP,F2,FABP1,FGF23,HP,
ITIH1,MT1B,PLG,SERPINA7,SERPINC1,SLC17A2,TM4SF5
ANXA10,BAAT,CDHR2,GKN2,KRTAP13-1,LGSN,MAGEA4,
NAPSA,NKX2-1,PAEP,BPIFA1,PSAPL1,SCGB3A2,SFTA2,
SFTA3,SFTPB,SFTPC,SLC26A9,SPINK1,TM4SF20,TM4SF5

ABCC2,BAAT,CPLX2,CPN1,F10,FAM138F,KCNA2,
KRT40,MAGEA9B,NODAL,NXF2,NXF5,PATE3,RTP3,
SH3RF3,SLC19A3,SNORA38B,SPANXN5,SPESP1,EWSAT1,TRPM3
APOA5,BAAT,C8B,CCDC152,CEL,CELP,CHRFAM7A,
CHRNA7,FABP2,FADS6,IFNE,IRAK2,CERS2,MT1H,
PAH,PITPNA,PLG,SEPP1,SLC15A1,SLC30A2,SLC6A19
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

Top
check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

Top
Pharmacological Information for BAAT
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB00145bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)approved; nutraceuticalGlycine


Top
Cross referenced IDs for BAAT
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



Copyright © 2016-Present - The Univsersity of Texas Health Science Center at Houston @
Site Policies | State of Texas