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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for BAAT |
Basic gene info. | Gene symbol | BAAT |
Gene name | bile acid CoA:amino acid N-acyltransferase | |
Synonyms | BACAT|BAT | |
Cytomap | UCSC genome browser: 9q22.3 | |
Genomic location | chr9 :104122698-104145801 | |
Type of gene | protein-coding | |
RefGenes | NM_001127610.1, NM_001701.3, | |
Ensembl id | ENSG00000136881 | |
Description | bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid-CoA:amino acid N-acyltransferaselong-chain fatty-acyl-CoA hydrolase | |
Modification date | 20141207 | |
dbXrefs | MIM : 602938 | |
HGNC : HGNC | ||
Ensembl : ENSG00000136881 | ||
HPRD : 08376 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BAAT | |
BioGPS: 570 | ||
Gene Expression Atlas: ENSG00000136881 | ||
The Human Protein Atlas: ENSG00000136881 | ||
Pathway | NCI Pathway Interaction Database: BAAT | |
KEGG: BAAT | ||
REACTOME: BAAT | ||
ConsensusPathDB | ||
Pathway Commons: BAAT | ||
Metabolism | MetaCyc: BAAT | |
HUMANCyc: BAAT | ||
Regulation | Ensembl's Regulation: ENSG00000136881 | |
miRBase: chr9 :104,122,698-104,145,801 | ||
TargetScan: NM_001127610 | ||
cisRED: ENSG00000136881 | ||
Context | iHOP: BAAT | |
cancer metabolism search in PubMed: BAAT | ||
UCL Cancer Institute: BAAT | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for BAAT(metabolism pathway, cancer, disease, phenome) |
Cancer Description | |
Cancer | CGAP: BAAT |
Familial Cancer Database: BAAT |
* This gene is included in those cancer gene databases. |
Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
Metabolic Pathway Description | |
KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS |
Others | |
OMIM | |
Orphanet | |
Disease | KEGG Disease: BAAT |
MedGen: BAAT (Human Medical Genetics with Condition) | |
ClinVar: BAAT | |
Phenotype | MGI: BAAT (International Mouse Phenotyping Consortium) |
PhenomicDB: BAAT |
Mutations for BAAT |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
Structural Variants in COSMIC: go to COSMIC mutation histogram |
There's no structural variation information in COSMIC data for this gene. |
Related fusion transcripts : go to Chitars2.0 |
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows BAAT related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
Other DBs for Structural Variants |
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Copy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr |
There's no copy number variation information in COSMIC data for this gene. |
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SNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation |
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Somatic Mutation Counts per Tissue in COSMIC data |
Stat. for Non-Synonymous SNVs (# total SNVs=42) | (# total SNVs=14) |
(# total SNVs=2) | (# total SNVs=1) |
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Top 10 SNVs Having the Most Samples in COSMIC data |
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr9:104124952-104124952 | p.Q339K | 3 |
chr9:104125001-104125001 | p.F322F | 3 |
chr9:104125007-104125007 | p.F320F | 3 |
chr9:104130542-104130542 | p.R177W | 3 |
chr9:104125077-104125077 | p.R297H | 2 |
chr9:104133605-104133605 | p.Q28E | 2 |
chr9:104133628-104133628 | p.R20Q | 2 |
chr9:104133503-104133503 | p.H62Y | 2 |
chr9:104133260-104133260 | p.R143* | 2 |
chr9:104124751-104124751 | p.L406F | 2 |
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SNV Counts per Each Loci in TCGA data |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample | 1 | 2 |   | 3 |   |   | 2 |   | 2 | 1 | 1 | 11 | 3 |   |   |   | 15 | 4 |   | 10 |
# mutation | 1 | 2 |   | 3 |   |   | 2 |   | 2 | 1 | 1 | 11 | 3 |   |   |   | 14 | 5 |   | 11 |
nonsynonymous SNV |   | 1 |   | 2 |   |   | 2 |   | 2 | 1 | 1 | 9 | 3 |   |   |   | 10 | 3 |   | 7 |
synonymous SNV | 1 | 1 |   | 1 |   |   |   |   |   |   |   | 2 |   |   |   |   | 4 | 2 |   | 4 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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Top 10 SNVs Having the Most Samples in TCGA data |
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr9:104130542 | p.F322F,BAAT | 3 |
chr9:104125001 | p.F320F,BAAT | 3 |
chr9:104125007 | p.R177W,BAAT | 3 |
chr9:104124832 | p.R297H,BAAT | 1 |
chr9:104133522 | p.G145D,BAAT | 1 |
chr9:104124985 | p.T376M,BAAT | 1 |
chr9:104125209 | p.Y270Y,BAAT | 1 |
chr9:104133228 | p.R143L,BAAT | 1 |
chr9:104124839 | p.P367S,BAAT | 1 |
chr9:104133542 | p.P263S,BAAT | 1 |
Other DBs for Point Mutations |
Copy Number for BAAT in TCGA |
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for BAAT |
Gene Expression in Cancer Cell-lines (CCLE) |
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
Differential Gene Expression in Primary Tumors (TCGA) |
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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CNV vs Gene Expression Plot |
* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
Co-Expressed gene's network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
APCS,APOA2,APOA4,APOC3,ARG1,BAAT,C8A, C9,CREB3L3,CRP,F2,FABP1,FGF23,HP, ITIH1,MT1B,PLG,SERPINA7,SERPINC1,SLC17A2,TM4SF5 | ANXA10,BAAT,CDHR2,GKN2,KRTAP13-1,LGSN,MAGEA4, NAPSA,NKX2-1,PAEP,BPIFA1,PSAPL1,SCGB3A2,SFTA2, SFTA3,SFTPB,SFTPC,SLC26A9,SPINK1,TM4SF20,TM4SF5 | ||||
ABCC2,BAAT,CPLX2,CPN1,F10,FAM138F,KCNA2, KRT40,MAGEA9B,NODAL,NXF2,NXF5,PATE3,RTP3, SH3RF3,SLC19A3,SNORA38B,SPANXN5,SPESP1,EWSAT1,TRPM3 | APOA5,BAAT,C8B,CCDC152,CEL,CELP,CHRFAM7A, CHRNA7,FABP2,FADS6,IFNE,IRAK2,CERS2,MT1H, PAH,PITPNA,PLG,SEPP1,SLC15A1,SLC30A2,SLC6A19 |
Co-Expressed gene's Protein-protein interaction Network Plot |
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Interacting Genes (from Pathway Commons) |
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Pharmacological Information for BAAT |
Cross-referenced pharmacological DB IDs from Uniprot |
DB Category | DB Name | DB's ID and Url link |
Drug-Gene Interaction Network |
* Gene Centered Interaction Network. |
* Drug Centered Interaction Network. |
DrugBank ID | Target Name | Drug Groups | Generic Name | Drug Centered Network | Drug Structure |
DB00145 | bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) | approved; nutraceutical | Glycine |
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Cross referenced IDs for BAAT |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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