Cancer Cell Metabolism Gene Database

  Cancer Cell Metabolism Gene DB

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Phenotypic Information (metabolism pathway, cancer, disease, phenome)

Mutations: SVs, CNVs, SNVs

Gene expression: GE, Protein, DEGE, CNV vs GE

Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG

Pharmacological Information: Drug-Gene Network

Cross referenced IDs

Gene Summary for AKR1B10
Basic gene info.Gene symbolAKR1B10
Gene namealdo-keto reductase family 1, member B10 (aldose reductase)
SynonymsAKR1B11|AKR1B12|ALDRLn|ARL-1|ARL1|HIS|HSI
CytomapUCSC genome browser: 7q33
Genomic locationchr7 :134212343-134226166
Type of geneprotein-coding
RefGenesNM_020299.4,
Ensembl idENSG00000198074
DescriptionARPSI reductasealdo-keto reductase family 1 member B10aldo-keto reductase family 1, member B11 (aldose reductase-like)aldose reductase-like 1aldose reductase-like peptidealdose reductase-related proteinhARPsmall intestine reductase
Modification date20141207
dbXrefs MIM : 604707
HGNC : HGNC
Ensembl : ENSG00000198074
HPRD : 05271
Vega : OTTHUMG00000155356
ProteinUniProt: O60218
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_AKR1B10
BioGPS: 57016
Gene Expression Atlas: ENSG00000198074
The Human Protein Atlas: ENSG00000198074
PathwayNCI Pathway Interaction Database: AKR1B10
KEGG: AKR1B10
REACTOME: AKR1B10
ConsensusPathDB
Pathway Commons: AKR1B10
MetabolismMetaCyc: AKR1B10
HUMANCyc: AKR1B10
RegulationEnsembl's Regulation: ENSG00000198074
miRBase: chr7 :134,212,343-134,226,166
TargetScan: NM_020299
cisRED: ENSG00000198074
ContextiHOP: AKR1B10
cancer metabolism search in PubMed: AKR1B10
UCL Cancer Institute: AKR1B10
Assigned class in ccmGDBA - This gene has a literature evidence and it belongs to cancer gene.
References showing role of AKR1B10 in cancer cell metabolism1. Ruiz FX, Porte S, Pares X, Farres J (2012) Biological role of aldo-keto reductases in retinoic Acid biosynthesis and signaling. Front Pharmacol 3: 58. doi: 10.3389/fphar.2012.00058. pmid: 3328219. go to article
2. Balendiran GK, Martin HJ, El-Hawari Y, Maser E (2009) Cancer biomarker AKR1B10 and carbonyl metabolism. Chem Biol Interact 178: 134-137. doi: 10.1016/j.cbi.2008.10.044. go to article
3. Zhang W, Li H, Yang Y, Liao J, Yang GY (2014) Knockdown or inhibition of aldo-keto reductase 1B10 inhibits pancreatic carcinoma growth via modulating Kras-E-cadherin pathway. Cancer Lett 355: 273-280. doi: 10.1016/j.canlet.2014.09.031. pmid: 4462172. go to article
4. Nishinaka T, Miura T, Sakou M, Hidaka C, Sasaoka C, et al. (2015) Down-regulation of aldo-keto reductase AKR1B10 gene expression by a phorbol ester via the ERK/c-Jun signaling pathway. Chem Biol Interact 234: 274-281. doi: 10.1016/j.cbi.2014.11.013. go to article

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Phenotypic Information for AKR1B10(metabolism pathway, cancer, disease, phenome)
check002.gifCancer Description
Cancer CGAP: AKR1B10
Familial Cancer Database: AKR1B10
* This gene is included in those cancer gene databases.

Oncogene 1

Tumor Suppressor gene 2

Cancer Gene Census 3

CancerGenes 4

Network of Cancer Gene 5

Significant driver gene in

Therapeutic Vulnerabilities in Cancer1

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

check002.gifMetabolic Pathway Description
KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM
KEGG_LINOLEIC_ACID_METABOLISM
KEGG_BUTANOATE_METABOLISM

check002.gifOthers
OMIM 604707; gene.
Orphanet
DiseaseKEGG Disease: AKR1B10
MedGen: AKR1B10 (Human Medical Genetics with Condition)
ClinVar: AKR1B10
PhenotypeMGI: AKR1B10 (International Mouse Phenotyping Consortium)
PhenomicDB: AKR1B10

Mutations for AKR1B10
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

check002.gifStructural Variants in COSMIC: go to COSMIC mutation histogram

- Statistics for Tissue and Mutation typeTop
- For Inter-chromosomal Variations
There's no inter-chromosomal structural variation.
- For Intra-chromosomal Variations
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'.
SampleSymbol_aChr_aStart_aEnd_aSymbol_bChr_bStart_bEnd_b
pancreasAKR1B10chr7134216181134216201AKR1B10chr7134217976134217996
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract)

check002.gifRelated fusion transcripts : go to Chitars2.0
* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows AKR1B10 related fusion information.
IDHead GeneTail Gene
AccessionGene_aqStart_aqEnd_aChromosome_atStart_atEnd_aGene_aqStart_aqEnd_aChromosome_atStart_atEnd_a

check002.gifOther DBs for Structural Variants
Structural Variants in Ensembl: go to Ensembl Structural variation
Structural Variants in dbVar: go to dbVar

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check002.gifCopy Number Variations in COSMIC: go to COSMIC mutation CNV/Expr
 
Mutation type/ Tissue IDbrcacnscervendomehaematopokidnLintestliverlungnsovarypancreprostskinstomathyrourina
Total # sample             1   
GAIN (# sample)             1   
LOSS (# sample)                 
cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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check002.gifSNV Counts per Each Loci in COSMIC data: go to COSMIC point mutation

 : Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=7

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check002.gifSomatic Mutation Counts per Tissue in COSMIC data
Stat. for Non-Synonymous SNVs
(# total SNVs=28)
Stat. for Synonymous SNVs
(# total SNVs=17)
Stat. for Deletions
(# total SNVs=0)
Stat. for Insertions
(# total SNVs=0)
There's no deleted snv.There's no inserted snv.

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check002.gifTop 10 SNVs Having the Most Samples in COSMIC data
* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.
GRCh37 positionMutation(aa)Unique sampleID count
chr7:134221826-134221826p.T192T7
chr7:134217804-134217804p.G134R3
chr7:134215403-134215403p.L25L2
chr7:134223007-134223007p.A268V2
chr7:134221874-134221874p.T208T2
chr7:134212697-134212697p.K12*2
chr7:134212705-134212705p.P14P1
chr7:134221440-134221440p.A156A1
chr7:134223761-134223761p.N300N1
chr7:134215553-134215553p.I75I1

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check002.gifSNV Counts per Each Loci in TCGA data

 : non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=2

Point Mutation/ Tissue ID1234567891011121314151617181920
# sample1  52 3 2  113   143 3
# mutation1  42 3 2  123   153 4
nonsynonymous SNV1  21 3 1  93   82 3
synonymous SNV   21   1  3    71 1
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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check002.gifTop 10 SNVs Having the Most Samples in TCGA data
* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.
Genomic PositionMutation(aa)Unique sampleID count
chr7:134221874p.T208T2
chr7:134212705p.V28V1
chr7:134221899p.I132I1
chr7:134216705p.S227S1
chr7:134222969p.A35V1
chr7:134217821p.G134R1
chr7:134215412p.L228L1
chr7:134222353p.A38A1
chr7:134216707p.A136V1
chr7:134222989p.E236K1

check002.gifOther DBs for Point Mutations
Point Mutation Table of Ensembl: go to Ensembl variation table
Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

check002.gifCopy Number for AKR1B10 in TCGA
* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.
cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for AKR1B10

check002.gifGene Expression in Cancer Cell-lines (CCLE)
* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

check002.gifDifferential Gene Expression in Primary Tumors (TCGA)
* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))
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check002.gifCNV vs Gene Expression Plot
* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types


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Gene-Gene Network Information
check002.gifCo-Expressed gene's network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

AKR1B10,AKR1C1,AKR1C3,ALDH3A1,BCL2L10,C10orf99,FOXE1,
GAGE12J,GAGE2B,GAGE8,GPX2,IQCF2,KRT13,KRT74,
LOC285629,NKX2-4,RBMXL2,UGT1A5,VCX,VCX3A,VCY
ADH7,AKR1B10,ALDH3A1,C10orf99,CAPNS2,CYP4F3,GJB6,
KRT13,KRT4,KRT6A,KRT78,KRTDAP,SOX2,SPRR1A,
SPRR1B,SPRR2A,SPRR2D,SPRR3,TMPRSS11D,UGT1A7,UPK1B

AKR1B10,AKR1B15,BTNL3,C11orf86,MIEN1,AXDND1,DHRS9,
ERBB2,KRT20,MALL,MMP28,MSL1,PPP1R1B,RAPGEFL1,
TCAP,TMEM54,TMEM82,TSPAN1,UGT1A1,UGT1A8,WIPF2
ABCD3,AKR1B10,AP1AR,CROT,CRYL1,CTAGE5,ETFDH,
FAM73B,FLVCR2,HADHB,KALRN,NCOA4,OCIAD2,PDXP,
PRR13,RBKS,RRAS2,STK17B,TMEM139,SLC35G1,UGT1A9
check002.gifCo-Expressed gene's Protein-protein interaction Network Plot
* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types

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check002.gifInteracting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for AKR1B10
check002.gifCross-referenced pharmacological DB IDs from Uniprot
DB CategoryDB NameDB's ID and Url link
ChemistryBindingDB O60218; -.
ChemistryChEMBL CHEMBL5983; -.
Organism-specific databasesPharmGKB PA24676; -.
Organism-specific databasesCTD 57016; -.

check002.gifDrug-Gene Interaction Network
* Gene Centered Interaction Network.
* Drug Centered Interaction Network.
DrugBank IDTarget NameDrug GroupsGeneric NameDrug Centered NetworkDrug Structure
DB02383aldo-keto reductase family 1, member B10 (aldose reductase)experimentalTolrestat
DB03461aldo-keto reductase family 1, member B10 (aldose reductase)experimental2'-Monophosphoadenosine 5'-Diphosphoribose
DB08772aldo-keto reductase family 1, member B10 (aldose reductase)experimental3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID


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Cross referenced IDs for AKR1B10
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information



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