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Phenotypic Information (metabolism pathway, cancer, disease, phenome) | |
Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG | |
Gene Summary for PSME2 |
Basic gene info. | Gene symbol | PSME2 |
Gene name | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | |
Synonyms | PA28B|PA28beta|REGbeta | |
Cytomap | UCSC genome browser: 14q11.2 | |
Genomic location | chr14 :24612573-24615855 | |
Type of gene | protein-coding | |
RefGenes | NM_002818.2, | |
Ensembl id | ENSG00000100911 | |
Description | 11S regulator complex beta subunit11S regulator complex subunit betaMCP activator, 31-kD subunitREG-betaactivator of multicatalytic protease subunit 2cell migration-inducing protein 22proteasome activator 28 subunit betaproteasome activator 28-beta | |
Modification date | 20141207 | |
dbXrefs | MIM : 602161 | |
HGNC : HGNC | ||
Ensembl : ENSG00000100911 | ||
HPRD : 03697 | ||
Vega : OTTHUMG00000028797 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PSME2 | |
BioGPS: 5721 | ||
Gene Expression Atlas: ENSG00000100911 | ||
The Human Protein Atlas: ENSG00000100911 | ||
Pathway | NCI Pathway Interaction Database: PSME2 | |
KEGG: PSME2 | ||
REACTOME: PSME2 | ||
ConsensusPathDB | ||
Pathway Commons: PSME2 | ||
Metabolism | MetaCyc: PSME2 | |
HUMANCyc: PSME2 | ||
Regulation | Ensembl's Regulation: ENSG00000100911 | |
miRBase: chr14 :24,612,573-24,615,855 | ||
TargetScan: NM_002818 | ||
cisRED: ENSG00000100911 | ||
Context | iHOP: PSME2 | |
cancer metabolism search in PubMed: PSME2 | ||
UCL Cancer Institute: PSME2 | ||
Assigned class in ccmGDB | C |
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Phenotypic Information for PSME2(metabolism pathway, cancer, disease, phenome) |
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Cancer | CGAP: PSME2 |
Familial Cancer Database: PSME2 |
* This gene is included in those cancer gene databases. |
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Oncogene 1 | Significant driver gene in |
cf) number; DB name 1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/, 3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html, 4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long, 5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php, 1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/ |
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REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES REACTOME_METABOLISM_OF_MRNA REACTOME_METABOLISM_OF_RNA |
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OMIM | |
Orphanet | |
Disease | KEGG Disease: PSME2 |
MedGen: PSME2 (Human Medical Genetics with Condition) | |
ClinVar: PSME2 | |
Phenotype | MGI: PSME2 (International Mouse Phenotyping Consortium) |
PhenomicDB: PSME2 |
Mutations for PSME2 |
* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site. |
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- Statistics for Tissue and Mutation type | Top |
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- For Inter-chromosomal Variations |
There's no inter-chromosomal structural variation. |
- For Intra-chromosomal Variations |
* Intra-chromosomal variantions includes 'intrachromosomal amplicon to amplicon', 'intrachromosomal amplicon to non-amplified dna', 'intrachromosomal deletion', 'intrachromosomal fold-back inversion', 'intrachromosomal inversion', 'intrachromosomal tandem duplication', 'Intrachromosomal unknown type', 'intrachromosomal with inverted orientation', 'intrachromosomal with non-inverted orientation'. |
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Sample | Symbol_a | Chr_a | Start_a | End_a | Symbol_b | Chr_b | Start_b | End_b |
ovary | PSME2 | chr14 | 24612887 | 24612907 | chr14 | 24637616 | 24637636 |
cf) Tissue number; Tissue name (1;Breast, 2;Central_nervous_system, 3;Haematopoietic_and_lymphoid_tissue, 4;Large_intestine, 5;Liver, 6;Lung, 7;Ovary, 8;Pancreas, 9;Prostate, 10;Skin, 11;Soft_tissue, 12;Upper_aerodigestive_tract) |
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* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PSME2 related fusion information. |
ID | Head Gene | Tail Gene | Accession | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a | Gene_a | qStart_a | qEnd_a | Chromosome_a | tStart_a | tEnd_a |
AV646791 | PSME2 | 2 | 109 | 14 | 24614462 | 24614674 | ANKRD46 | 103 | 367 | 8 | 101534603 | 101534921 | |
AV651403 | PSME2 | 2 | 109 | 14 | 24614462 | 24614674 | ANKRD46 | 103 | 363 | 8 | 101534607 | 101534921 | |
AV652105 | PSME2 | 2 | 109 | 14 | 24614462 | 24614674 | ANKRD46 | 103 | 606 | 8 | 101534418 | 101534921 | |
AV651374 | PSME2 | 2 | 109 | 14 | 24614462 | 24614674 | ANKRD46 | 103 | 368 | 8 | 101534602 | 101534921 | |
BF205135 | PSME2 | 125 | 198 | 14 | 24615741 | 24615814 | RPS20 | 199 | 691 | 8 | 56985619 | 56987051 | |
BF884903 | PSME2 | 1 | 112 | 14 | 24614339 | 24614642 | SNAP91 | 104 | 123 | 6 | 84312558 | 84312577 | |
AW997232 | PSME2 | 3 | 236 | 14 | 24614613 | 24615821 | RAB10 | 233 | 383 | 2 | 26298749 | 26298901 | |
BG999584 | TGOLN2 | 26 | 302 | 2 | 85548105 | 85548383 | PSME2 | 301 | 556 | 14 | 24613284 | 24613539 |
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There's no copy number variation information in COSMIC data for this gene. |
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Stat. for Non-Synonymous SNVs (# total SNVs=12) | (# total SNVs=11) |
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(# total SNVs=0) | (# total SNVs=0) |
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* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID. |
GRCh37 position | Mutation(aa) | Unique sampleID count |
chr14:24615447-24615447 | p.V17V | 8 |
chr14:24612871-24612871 | p.R188W | 2 |
chr14:24612869-24612869 | p.R188R | 1 |
chr14:24613646-24613646 | p.K131R | 1 |
chr14:24614958-24614958 | p.F35L | 1 |
chr14:24613650-24613650 | p.P130S | 1 |
chr14:24614962-24614962 | p.R34I | 1 |
chr14:24613196-24613196 | p.K180N | 1 |
chr14:24614267-24614267 | p.L120L | 1 |
chr14:24615432-24615432 | p.Q22Q | 1 |
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Point Mutation/ Tissue ID | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
# sample |   |   |   |   |   |   | 1 |   |   | 1 |   | 2 | 2 |   |   | 1 | 4 | 2 |   | 5 |
# mutation |   |   |   |   |   |   | 1 |   |   | 1 |   | 2 | 2 |   |   | 1 | 4 | 2 |   | 5 |
nonsynonymous SNV |   |   |   |   |   |   | 1 |   |   | 1 |   | 1 | 1 |   |   |   | 4 | 2 |   | 3 |
synonymous SNV |   |   |   |   |   |   |   |   |   |   |   | 1 | 1 |   |   | 1 |   |   |   | 2 |
cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma]) |
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* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID. |
Genomic Position | Mutation(aa) | Unique sampleID count |
chr14:24612869 | p.R188W | 1 |
chr14:24614473 | p.S179F | 1 |
chr14:24612871 | p.E170E | 1 |
chr14:24614958 | p.K156R | 1 |
chr14:24613200 | p.V153V | 1 |
chr14:24614962 | p.Q143K | 1 |
chr14:24613226 | p.K131R | 1 |
chr14:24615432 | p.P130S | 1 |
chr14:24613431 | p.P109S | 1 |
chr14:24615758 | p.Q83E | 1 |
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* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene. |
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cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma] |
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Gene Expression for PSME2 |
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* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data. |
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* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis. (t test, adjusted p<0.05 (using Benjamini-Hochberg FDR)) |
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* This plots show the correlation between CNV and gene expression. |
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Gene-Gene Network Information |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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APOL1,APOL2,EMC9,HLA-B,IFI35,IRF1,IRF9, MRPL52,NEDD8,PSMA3,PSMB10,PSMB8,PSMB9,PSMC1, PSME1,PSME2,RNF181,RNF31,RPL36AL,TRIM21,UBE2L6 | LY6E,MANF,NANS,NFKBIE,PPIB,PRELID1,PSMB10, PSMB8,PSME1,PSME2,RAB34,RANBP1,RARRES3,RNASEH2A, RUVBL1,SDF2L1,SNRPF,SSR4,TAPBP,TOR3A,UBE2L6 |
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APOL2,BAK1,BATF2,BST2,EIF5A,ETV7,FBXO6, HLA-DMA,IRF1,NMI,PSMA3,PSMA6,PSMB10,PSMB8, PSMB9,PSME1,PSME2,RARRES3,RPL36AL,TAP1,UBE2L6 | APOL1,ASS1,CASP1,CXCL9,ETV7,FAM26F,GBP1, GBP4,GBP7,GZMB,HRASLS2,IFI35,IFITM1,LAP3, PARP9,PSMB10,PSMB9,PSME1,PSME2,STAT1,UBE2L6 |
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* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown. Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene |
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Pharmacological Information for PSME2 |
There's no related Drug. |
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Cross referenced IDs for PSME2 |
* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section |
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