Cancer Cell Metabolism Database ~~ Bioinformatics and Systems Medicine Laboratory ~~

Cancer Cell Metabolism Gene Database

Cancer Cell Metabolism Gene DB

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	Gene Summary
	Phenotypic Information (metabolism pathway, cancer, disease, phenome)
	Mutations : SVs, CNVs, SNVs
	Gene expression: GE, Protein, DEGE, CNV vs GE
	Gene-Gene Network Information: Co-Expression Network, Interacting Genes & KEGG
	Pharmacological Information: Drug-Gene Network
	Cross referenced IDs

Gene Summary for PTGS1

Basic gene info.	Gene symbol	PTGS1
	Gene name	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
	Synonyms	COX1\|COX3\|PCOX1\|PES-1\|PGG/HS\|PGHS-1\|PGHS1\|PHS1\|PTGHS
	Cytomap	UCSC genome browser: 9q32-q33.3
	Genomic location	chr9 :125133228-125157981
	Type of gene	protein-coding
	RefGenes	NM_000962.3, NM_001271164.1,NM_001271165.1,NM_001271166.1,NM_001271367.1, NM_001271368.1,NM_080591.2,
	Ensembl id	ENSG00000095303
	Description	PGH synthase 1cyclooxygenase-1prostaglandin G/H synthase 1prostaglandin H2 synthase 1
	Modification date	20141207
dbXrefs	MIM : 176805
	HGNC : HGNC
	Ensembl : ENSG00000095303
	HPRD : 07518
	Vega : OTTHUMG00000020605
Protein	UniProt: P23219 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PTGS1
	BioGPS: 5742
	Gene Expression Atlas: ENSG00000095303
	The Human Protein Atlas: ENSG00000095303
Pathway	NCI Pathway Interaction Database: PTGS1
	KEGG: PTGS1
	REACTOME: PTGS1
	ConsensusPathDB
	Pathway Commons: PTGS1
Metabolism	MetaCyc: PTGS1
	HUMANCyc: PTGS1
Regulation	Ensembl's Regulation: ENSG00000095303
	miRBase: chr9 :125,133,228-125,157,981
	TargetScan: NM_000962
	cisRED: ENSG00000095303
Context	iHOP: PTGS1
	cancer metabolism search in PubMed: PTGS1
	UCL Cancer Institute: PTGS1
Assigned class in ccmGDB	B - This gene belongs to cancer gene.

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Phenotypic Information for PTGS1(metabolism pathway, cancer, disease, phenome)

Cancer Description
Cancer	CGAP: PTGS1
	Familial Cancer Database: PTGS1

* This gene is included in those cancer gene databases.


Oncogene ¹	Tumor Suppressor gene ²	Cancer Gene Census ³	CancerGenes ⁴	Network of Cancer Gene ⁵	Significant driver gene in	Therapeutic Vulnerabilities in Cancer¹

cf) number; DB name
1 Oncogene; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
2 Tumor Suppressor gene; https://bioinfo.uth.edu/TSGene/,
3 Cancer Gene Census; http://www.nature.com/nrc/journal/v4/n3/abs/nrc1299.html,
4 CancerGenes; http://nar.oxfordjournals.org/content/35/suppl_1/D721.long,
5 Network of Cancer Gene; http://ncg.kcl.ac.uk/index.php,
1Therapeutic Vulnerabilities in Cancer; http://cbio.mskcc.org/cancergenomics/statius/

Metabolic Pathway Description
KEGG_ARACHIDONIC_ACID_METABOLISM

Others
OMIM	176805; gene. 176805; gene.
Orphanet
Disease	KEGG Disease: PTGS1
	MedGen: PTGS1 (Human Medical Genetics with Condition)
	ClinVar: PTGS1
Phenotype	MGI: PTGS1 (International Mouse Phenotyping Consortium)
Phenotype	PhenomicDB: PTGS1

Mutations for PTGS1

* Under tables are showing count per each tissue to give us broad intuition about tissue specific mutation patterns.You can go to the detailed page for each mutation database's web site.

Structural Variants in COSMIC : go to COSMIC mutation histogram

There's no structural variation information in COSMIC data for this gene.

Related fusion transcripts : go to Chitars2.0

* From mRNA Sanger sequences, Chitars2.0 arranged chimeric transcripts. This table shows PTGS1 related fusion information.

ID	Head Gene						Tail Gene
Accession	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a	Gene_a	qStart_a	qEnd_a	Chromosome_a	tStart_a	tEnd_a
AW899334	PTGS1	1	194	9	125140538	125140732	NDRG1	178	247	8	134251081	134251152
AI972452	PTGS1	7	173	9	125155415	125155581	SYNPO2	169	490	4	119952172	119952493
AA773408	PTGS1	1	203	9	125155143	125155344	GNAS	203	422	20	57470930	57471148

Other DBs for Structural Variants

Structural Variants in Ensembl: go to Ensembl Structural variation

Structural Variants in dbVar: go to dbVar

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Copy Number Variations in COSMIC : go to COSMIC mutation CNV/Expr

Mutation type/ Tissue ID

brca

cns

cerv

endome

haematopo

kidn

Lintest

liver

lung

ovary

pancre

prost

skin

stoma

thyro

urina

Total # sample

GAIN (# sample)

LOSS (# sample)

cf) Tissue ID; Tissue type (1; Breast, 2; Central_nervous_system, 3; Cervix, 4; Endometrium, 5; Haematopoietic_and_lymphoid_tissue, 6; Kidney, 7; Large_intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary_tract)

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SNV Counts per Each Loci in COSMIC data : go to COSMIC point mutation

: Non-synonymous mutation, : Synonymous mutation, Circle size denotes number of samples.
Maximum mutation count=1

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Somatic Mutation Counts per Tissue in COSMIC data

Stat. for Non-Synonymous SNVs (# total SNVs=4)	Stat. for Synonymous SNVs (# total SNVs=0)
	There's no s-snv.
Stat. for Deletions (# total SNVs=0)	Stat. for Insertions (# total SNVs=0)
There's no deleted snv.	There's no inserted snv.

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Top 10 SNVs Having the Most Samples in COSMIC data

* When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site,primary_histology,mutation(aa),pubmedID.

GRCh37 position	Mutation(aa)	Unique sampleID count
chr9:125143792-125143792	p.G213G	1
chr9:125154633-125154633	p.P537L	1
chr9:125154746-125154746	p.P575S	1
chr9:125140241-125140241	p.R53H	1
chr9:125140732-125140732	p.R78W	1
chr9:125140843-125140843	p.V115L	1
chr9:125143682-125143682	p.A177T	1
chr9:125143763-125143763	p.F204I	1

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SNV Counts per Each Loci in TCGA data

: non-synonymous mutation, : synonymous mutation, Circle size denotes number of samples.
maximum mutation count=3

Point Mutation/ Tissue ID	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
# sample		2		10	1		4					10	3	3	1	1	18	8		5
# mutation		2		11	1		4					11	3	3	1	1	23	9		6
nonsynonymous SNV		2		8	1		4					6	2	3		1	11	6		4
synonymous SNV				3								5	1		1		12	3		2

cf) Tissue ID; Tissue type (1; BLCA[Bladder Urothelial Carcinoma], 2; BRCA[Breast invasive carcinoma], 3; CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], 4; COAD[Colon adenocarcinoma], 5; GBM[Glioblastoma multiforme], 6; Glioma Low Grade, 7; HNSC[Head and Neck squamous cell carcinoma], 8; KICH[Kidney Chromophobe], 9; KIRC[Kidney renal clear cell carcinoma], 10; KIRP[Kidney renal papillary cell carcinoma], 11; LAML[Acute Myeloid Leukemia], 12; LUAD[Lung adenocarcinoma], 13; LUSC[Lung squamous cell carcinoma], 14; OV[Ovarian serous cystadenocarcinoma ], 15; PAAD[Pancreatic adenocarcinoma], 16; PRAD[Prostate adenocarcinoma], 17; SKCM[Skin Cutaneous Melanoma], 18:STAD[Stomach adenocarcinoma], 19:THCA[Thyroid carcinoma], 20:UCEC[Uterine Corpus Endometrial Carcinoma])

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Top 10 SNVs Having the Most Samples in TCGA data

* We represented just top 10 SNVs. When you move the cursor on each content, you can see more deailed mutation information on the Tooltip. Those are primary_site, primary_histology, mutation(aa), pubmedID.

Genomic Position	Mutation(aa)	Unique sampleID count
chr9:125140266	p.T61T,PTGS1	3
chr9:125148802	p.E356K,PTGS1	2
chr9:125154645	p.P493L,PTGS1	2
chr9:125148925	p.Y299Y,PTGS1	2
chr9:125148756	p.E315Q,PTGS1	2
chr9:125145892	p.G95R,PTGS1	1
chr9:125154583	p.G229S,PTGS1	1
chr9:125140732	p.R327H,PTGS1	1
chr9:125148786	p.A451V,PTGS1	1
chr9:125154756	p.N103I,PTGS1	1

Other DBs for Point Mutations

Point Mutation Table of Ensembl: go to Ensembl variation table

Mutation of cBioPortal: go to cBioPortal's Cross-cancer alteration summary

Copy Number for PTGS1 in TCGA

* Copy number data were extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered on Jan-05-2015. Function ProcessCNAData in TCGA-Assembler package was used to obtain gene-level copy number value which is calculated as the average copy number of the genomic region of a gene.

cf) Tissue ID[Tissue type]: BLCA[Bladder Urothelial Carcinoma], BRCA[Breast invasive carcinoma], CESC[Cervical squamous cell carcinoma and endocervical adenocarcinoma], COAD[Colon adenocarcinoma], GBM[Glioblastoma multiforme], Glioma Low Grade, HNSC[Head and Neck squamous cell carcinoma], KICH[Kidney Chromophobe], KIRC[Kidney renal clear cell carcinoma], KIRP[Kidney renal papillary cell carcinoma], LAML[Acute Myeloid Leukemia], LUAD[Lung adenocarcinoma], LUSC[Lung squamous cell carcinoma], OV[Ovarian serous cystadenocarcinoma ], PAAD[Pancreatic adenocarcinoma], PRAD[Prostate adenocarcinoma], SKCM[Skin Cutaneous Melanoma], STAD[Stomach adenocarcinoma], THCA[Thyroid carcinoma], UCEC[Uterine Corpus Endometrial Carcinoma]

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Gene Expression for PTGS1

Gene Expression in Cancer Cell-lines (CCLE)

* CCLE gene expression data were extracted from CCLE_Expression_Entrez_2012-10-18.res: Gene-centric RMA-normalized mRNA expression data.

Differential Gene Expression in Primary Tumors (TCGA)

* Normalized gene expression data of RNASeqV2 was extracted from TCGA using R package TCGA-Assembler. The URLs of all public data files on TCGA DCC data server were gathered at Jan-05-2015. Only eight cancer types have enough normal control samples for differential expression analysis.
(t test, adjusted p<0.05 (using Benjamini-Hochberg FDR))

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CNV vs Gene Expression Plot

* This plots show the correlation between CNV and gene expression.

: Open all plots for all cancer types

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Gene-Gene Network Information

Co-Expressed gene's network Plot

* Co-Expression network figures were drawn using R package igraph. Only the top 20 genes with the highest correlations were shown.
Red circle: input gene, orange circle: cell metabolism gene, sky circle: other gene

: Open all plots for all cancer types


ALDH3A2,ALOX5AP,C3AR1,CGA,ECEL1,EMB,GDAP1, GDF10,GPR128,JPH1,KRTAP4-4,LCMT1,LILRA1,LPAR5, MEGF10,PLIN2,PTGS1,QDPR,SLC27A2,SNX24,STOM	AHNAK2,ALOX5AP,AXL,C1S,CSF1R,CYBB,DNM1, FCGR2B,FCGR2C,GPNMB,LOC283070,MFAP4,NT5E,PTGIS, PTGS1,SELPLG,SLCO2B1,TGFBI,TLR8,TMEM35,WSCD2

AMOTL1,ANKRD35,ATP2B4,BNC2,CALD1,DOK6,FAM129A, FBXL7,FERMT2,FILIP1,ITGB3,ITPR1,MEIS1,MPDZ, MSRB3,PTGS1,RASL12,SLC8A1,SPARCL1,TSHZ3,ZEB1	ATP2B4,CACNA1C,CACNA1H,DMD,FRMPD4,GNAO1,KCNH2, KCNMA1,MEIS2,MRVI1,MYH11,NBEA,NRXN2,TENM3___TENM1, PLCD4,PPP1R12A,PRUNE2,PTGS1,SPEG,SVIL,TACR2

Co-Expressed gene's Protein-protein interaction Network Plot

: Open all plots for all cancer types

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Interacting Genes (from Pathway Commons)

: Open all interacting genes' information including KEGG pathway for all interacting genes from DAVID

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Pharmacological Information for PTGS1

Cross-referenced pharmacological DB IDs from Uniprot

DB Category	DB Name	DB's ID and Url link
Chemistry	BindingDB	P23219; -.
Chemistry	ChEMBL	CHEMBL2094253; -.
Chemistry	GuidetoPHARMACOLOGY	1375; -.
Chemistry	BindingDB	P23219; -.
Chemistry	ChEMBL	CHEMBL2094253; -.
Chemistry	GuidetoPHARMACOLOGY	1375; -.
Organism-specific databases	PharmGKB	PA24346; -.
Organism-specific databases	PharmGKB	PA24346; -.
Organism-specific databases	CTD	5742; -.
Organism-specific databases	CTD	5742; -.

Drug-Gene Interaction Network

* Gene Centered Interaction Network.

* Drug Centered Interaction Network.

DrugBank ID	Target Name	Drug Groups	Generic Name	Drug Centered Network	Drug Structure
DB00154	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved; nutraceutical	gamma-Homolinolenic acid
DB00159	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved; nutraceutical	Icosapent
DB00244	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Mesalazine
DB00316	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Acetaminophen
DB00328	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved; investigational	Indomethacin
DB00350	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Minoxidil
DB00461	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Nabumetone
DB00465	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Ketorolac
DB00469	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Tenoxicam
DB00500	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Tolmetin
DB00554	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved; investigational	Piroxicam
DB00573	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Fenoprofen
DB00586	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Diclofenac
DB00605	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Sulindac
DB00711	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Diethylcarbamazine
DB00712	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Flurbiprofen
DB00749	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved; investigational	Etodolac
DB00784	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Mefenamic acid
DB00788	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Naproxen
DB00795	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Sulfasalazine
DB00812	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Phenylbutazone
DB00814	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Meloxicam
DB00821	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Carprofen
DB00861	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Diflunisal
DB00870	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Suprofen
DB00936	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Salicyclic acid
DB00939	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Meclofenamic acid
DB00945	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Acetylsalicylic acid
DB00963	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Bromfenac
DB00991	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Oxaprozin
DB01009	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Ketoprofen
DB01014	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved; investigational	Balsalazide
DB01050	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Ibuprofen
DB01283	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved; investigational	Lumiracoxib
DB01294	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Bismuth Subsalicylate
DB01397	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Magnesium salicylate
DB01398	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Salicylate-sodium
DB01399	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Salsalate
DB01401	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Trisalicylate-choline
DB01419	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Antrafenine
DB01435	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Antipyrine
DB01600	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Tiaprofenic acid
DB01837	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	O-Acetylserine
DB01892	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	nutraceutical	Hyperforin
DB02047	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	2-(1,1'-Biphenyl-4-Yl)Propanoic Acid
DB02110	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	Protoporphyrin Ix Containing Co
DB02198	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	2-Bromoacetyl Group
DB02266	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	Flufenamic Acid
DB02379	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	Beta-D-Glucose
DB02687	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	Beta-D-Mannose
DB02709	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental; investigational	Resveratrol
DB02773	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	(3-Chloro-4-Propoxy-Phenyl)-Acetic Acid
DB02944	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	Alpha-D-Mannose
DB03014	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	Heme
DB03667	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	Acetic Acid Salicyloyl-Amino-Ester
DB03752	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid
DB03753	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	Flurbiprofen Methyl Ester
DB03783	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental; withdrawn	Phenacetin
DB04552	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Niflumic Acid
DB04557	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	Arachidonic Acid
DB04817	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	withdrawn	Dipyrone
DB06725	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Lornoxicam
DB06802	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Nepafenac
DB07981	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1R)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE
DB07983	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID
DB07984	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	experimental	2-[1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOL-3-YL]-N-[(1S)-1-(HYDROXYMETHYL)PROPYL]ACETAMIDE
DB00532	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Mephenytoin
DB01174	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Phenobarbital
DB00252	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Phenytoin
DB00347	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Trimethadione
DB00917	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Dinoprostone
DB01240	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved	Epoprostenol
DB00482	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	approved; investigational	Celecoxib

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Cross referenced IDs for PTGS1

* We obtained these cross-references from Uniprot database. It covers 150 different DBs, 18 categories. http://www.uniprot.org/help/cross_references_section

: Open all cross reference information